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All Journal Pharmacoscript Tashdiq: Jurnal Kajian Agama dan Dakwah
Nur, Aisyah
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Religion Humanities Chemistry Education Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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Hermeneutika Cinta dan Takdir: Menyingkap Makna Ambigu dalam Novel Di Bawah Lindungan Ka’bah Karya Buya Hamka Melalui Lensa Jean Paul Ricoeur Nur, Aisyah; Devina Novela
Tashdiq: Jurnal Kajian Agama dan Dakwah Vol. 9 No. 1 (2024): Tashdiq: Jurnal Kajian Agama dan Dakwah
Publisher : Cahaya Ilmu Bangsa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4236/tashdiq.v9i1.8815

Abstract

Penelitian ini secara umum mendeskripsikan hermeneutika Jean Paul Ricoeur dalam novel Di Bawah Lindungan Ka’bah karya Buya Hamka. Sedangkan secara khusus bertujuan menganalisis makna cinta dan takdir serta makna ambigu pada novel Di Bawah Lindungan Ka’bah karya Buya Hamka. Data penelitian ini bersumber dari novel Di Bawah Lindungan Ka’bah karya Buya Hamka. Data dikumpulkan melalui teknik baca, simak, dan catat. Hasil penelitian ini menunjukkan bahwa kata-kata dalam novel tersebut banyak mengandung simbol cinta dan takdir. Berdasarkan hasil penelitian disimpulkan bahwa novel Di Bawah Lindungan Ka’bah mengandung simbol cinta dan takdir yang tidak hanya digambarkan sebagai sesuatu yang tidak dapat diubah, tetapi juga sebagai ujian kesabaran dan keikhlasan. Menerima takdir dengan penuh kepasrahan kepada Allah, sebuah sikap yang mencerminkan nilai-nilai keimanan dan ketaatan kepada Tuhan. Cinta sejati tidak hanya berorientasi pada kebahagiaan duniawi, tetapi juga melibatkan kepasrahan kepada kehendak Allah. Cinta sejati akan menemukan jalannya di kehidupan akhirat.
COMPUTATIONAL INSIGHT INTO PIPER RETROFRACTUM CONSTITUENTS TARGETTING MAO-B IN PARKINSON'S DISEASE Nur, Aisyah; Sri, Wahyuni; Kurnia Ulla, Aprilliana; Rifa Alya, Salsabilla; Nayla Maymuna, Fathin; Agus, Rusdin; Dhania, Novitasari
Pharmacoscript Vol. 9 No. 1 (2026): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v9i1.2349

Abstract

Parkinson’s disease, characterized as a progressive neurodegenerative condition, represents a significant contributor to mortality in Indonesia. Piper retrofractum, a Piperaceae species rich in alkaloids, has been reported to contain compounds with neuroactive potential, similar to other Piper species in which Monoamine Oxidase-B (MAO-B) inhibition has been documented. However, no computational study has evaluated the interaction between Piper retrofractum bioactive compounds and MAO-B. = aimed to evaluate the MAO-B inhibitory potential of bioactive compounds from Piper retrofractum. Ten bioactive compounds from Piper retrofractum were screened and analyzed using Lipinski’s rules, PreADMET, pharmacophore modeling (Ligandscout 4.4.5), and molecular docking (AutoDock 4.2.6). The findings revealed that all test compounds met Lipinski's rule of Five. From the PreADMET results, Alismoxide showed a high Blood-Brain Barrier (BBB) crossing capacity of 4.59529. Trans-fagaramide was identified as the optimal pharmacophore match, displaying a fit score of 34.57. Meanwhile, from the molecular docking results, the most promising pharmacological candidate was piperolein-B, which formed a hydrogen bond with the amino acid residue LEU: A56, similar to the native ligand, with an inhibition constant of 0.015 μM and a binding energy of -10.6 kcal/mol. From these results, the bioactive compounds from Piper retrofractum can interact with the MAO-B receptor. These findings are computational predictions and require further experimental validation to confirm their potential for Parkinson’s disease treatment.
Co-Authors Agus, Rusdin Devina Novela Dhania, Novitasari Kurnia Ulla, Aprilliana Nayla Maymuna, Fathin Rifa Alya, Salsabilla Sri, Wahyuni