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All Journal Borneo Journal Of Pharmascientech Journal of Experimental and Clinical Pharmacy (JECP) Sasambo Journal of Pharmacy
Nurfitria Junita
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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FORMULASI SEDIAAN MOUTHWASH EKSTRAK ETANOL BUNGAMAWAR MERAH (Rosa damascena Mill) SEBAGAI ANTIBAKTERI TERHADAP Streptococcus mutans Nurfitria Junita; Nielma Auliah; Wantry Diasny
BORNEO JOURNAL OF PHARMASCIENTECH Vol 4 No 2 (2020): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v4i2.341

Abstract

It has been conducted a research about Formulation of Red Rose Ethanol Extract ofMouthwash (Rosa damascena Mill) as Antibacterial toward Streptococcus mutans. Thisresearch aim at knowing the activity of Red Rose Ethanol Extract of Mouthwash (Rosadamascena Mill) as Antibacterial toward Streptococcus mutans. In this study, usingexperimental research by formulating the ethanol extract of red rose (Rosa damascena Mill)mouthwash, then tested against Streptococcus mutans bacteria using the agar diffusionmethod. The ethanol extract of red rose (Rosa damascena Mill) mouthwash was prepared inthree concentrations, namely 1%, 3%, 5%, and control solution. The various concentrationswere tested for their antibacterial activity and an evaluation of the Mouthwash byorganoleptic observation, pH and cycling test. Meanwhile, the antibacterial activity test usedagar diffusion method using agar well diffusion. Results of the measurement of the largestaverage inhibition zone at a concentration of 5% of 21.4 mm. Result showed that physicalstability of mouthwash tended to stable on the low temperature storage (4°C) and had aninhibitory level in strong category in obstructing the growth of Streptococcusmutans
The influence concentration gel agent propolis combination of mulberry leaf on the growth of the bacteria Propionibacterium acnes Prayitno Setiawan; Nurfitria Junita
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.126

Abstract

This research was carried out with the aim of determining the inhibitory power of the combination gel of propolis extract and mulberry leaf extract against Propionibacterium acnes bacteria and determining the concentration of propolis extract that provided the greatest inhibitory power against the test bacteria. The research method includes the extraction of mulberry leaves by maceration using 70% ethanol as a solvent and the propolis extract used is a ready-to-use extract. The formulations were designed with various concentrations of propolis (0.5%, 1%, 1.5%) and 0.5% mulberry leaf concentration. Testing the antimicrobial activity of propolis extract in combination with mulberry extract in gel preparations against the growth of Propionibacterium acnes bacteria was carried out using the agar diffusion method. The results showed that the average diameter of the inhibition area at 0.5% concentration was 36.87 mm, at 1% concentration was 44.557 mm and at 1.5% concentration was 45.97 mm, positive control was 49.21 mm. Based on the data obtained, it is concluded that the gel formula with a propolis concentration of 1.5% is the preparation with the largest zone of inhibition.
Acute Toxicity Test of Bougainvillea glabra Choisy Leaf Extract Against Artemia salina Leach Larvae Using the Brine Shrimp Lethality Test Method Nur Fadilla; Muhammad Asri SR; Nurfitria Junita; Suryanita Suryanita
Journal of Experimental and Clinical Pharmacy (JECP) Vol 6, No 2 (2026): August 2026
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v6i2.1526

Abstract

Bougainvillea plants are often referred to as paper flowers because the texture of the petals resembles paper. The leaves of this plant contain several metabolite compounds, such as alkaloids, flavonoids, saponins, and tannins, that have potential as anticancer. This study aims to determine the acute toxicity and LC50 value of paper flower leaf extract (Bougainvillea glabra Choisy) to shrimp larvae (Artemia salina Leach) using the Brine Shrimp Lethality Test (BSLT) method. This research method is experimental research with phytochemical screening testing and an acute toxicity test of B. glabra Choisy leaf extract against shrimp larvae (Artemia salina Leach) with the BSLT method. The results of this study showed that the phytochemical screening of B. glabra leaf extract contained alkaloid, flavonoid, saponin, and tannin compounds, with an LC50 value of 225.94 μg/mL. It is concluded that paper flower leaf extract has a toxic effect on Artemia salina Leach larvae because the LC50 value is 225.94 μg/mL with a moderate toxic category.
Co-Authors Muhammad Asri SR Nielma Auliah Nur Fadilla Prayitno Setiawan Suryanita Suryanita Wantry Diasny