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All Journal JURNAL FARMASIMED (JFM) Borneo Journal Of Pharmascientech Sasambo Journal of Pharmacy
Nurfitria Junita
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Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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FORMULASI SEDIAAN MOUTHWASH EKSTRAK ETANOL BUNGAMAWAR MERAH (Rosa damascena Mill) SEBAGAI ANTIBAKTERI TERHADAP Streptococcus mutans Nurfitria Junita; Nielma Auliah; Wantry Diasny
BORNEO JOURNAL OF PHARMASCIENTECH Vol 4 No 2 (2020): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v4i2.341

Abstract

It has been conducted a research about Formulation of Red Rose Ethanol Extract ofMouthwash (Rosa damascena Mill) as Antibacterial toward Streptococcus mutans. Thisresearch aim at knowing the activity of Red Rose Ethanol Extract of Mouthwash (Rosadamascena Mill) as Antibacterial toward Streptococcus mutans. In this study, usingexperimental research by formulating the ethanol extract of red rose (Rosa damascena Mill)mouthwash, then tested against Streptococcus mutans bacteria using the agar diffusionmethod. The ethanol extract of red rose (Rosa damascena Mill) mouthwash was prepared inthree concentrations, namely 1%, 3%, 5%, and control solution. The various concentrationswere tested for their antibacterial activity and an evaluation of the Mouthwash byorganoleptic observation, pH and cycling test. Meanwhile, the antibacterial activity test usedagar diffusion method using agar well diffusion. Results of the measurement of the largestaverage inhibition zone at a concentration of 5% of 21.4 mm. Result showed that physicalstability of mouthwash tended to stable on the low temperature storage (4°C) and had aninhibitory level in strong category in obstructing the growth of Streptococcusmutans
The influence concentration gel agent propolis combination of mulberry leaf on the growth of the bacteria Propionibacterium acnes Prayitno Setiawan; Nurfitria Junita
Sasambo Journal of Pharmacy Vol. 3 No. 1 (2022): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v3i1.126

Abstract

This research was carried out with the aim of determining the inhibitory power of the combination gel of propolis extract and mulberry leaf extract against Propionibacterium acnes bacteria and determining the concentration of propolis extract that provided the greatest inhibitory power against the test bacteria. The research method includes the extraction of mulberry leaves by maceration using 70% ethanol as a solvent and the propolis extract used is a ready-to-use extract. The formulations were designed with various concentrations of propolis (0.5%, 1%, 1.5%) and 0.5% mulberry leaf concentration. Testing the antimicrobial activity of propolis extract in combination with mulberry extract in gel preparations against the growth of Propionibacterium acnes bacteria was carried out using the agar diffusion method. The results showed that the average diameter of the inhibition area at 0.5% concentration was 36.87 mm, at 1% concentration was 44.557 mm and at 1.5% concentration was 45.97 mm, positive control was 49.21 mm. Based on the data obtained, it is concluded that the gel formula with a propolis concentration of 1.5% is the preparation with the largest zone of inhibition.
Antihyperglycemic Effectiveness Test of 96% Ethanol Extract of Nutmeg (Myristica fragrans Houtt.) Stem Bark in Streptozotocin-Induced Mus musculus Nurfitria Junita; Nirwana Putri Mastur
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/yysjpg86

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by an increase in blood glucose levels. The bark of nutmeg (Myristica fragrans Houtt.) is known to have antihyperglycemic potential because it contains bioactive compounds such as flavonoids, alkaloids, tannins, and saponins. The nutmeg plant has benefits as an antidiabetic, antifungal, and antibacterial agent. Objective: This study aimed to evaluate the effectiveness of 96% ethanol extract of nutmeg bark as a blood glucose-lowering agent in male mice (Mus musculus) induced with streptozotocin. Method: This experimental research was conducted on 25 mice using a randomized design, divided into five groups of five mice each. The material was extracted using the maceration method with 95% ethanol. Results: Diabetes in mice was induced with streptozotocin at a dose of 40 mg/kg BW. Group I received 1% Na-CMC (negative control), Group II received glibenclamide (positive control), and Groups III–V received ethanol extract of nutmeg bark at doses of 50, 100, and 200 mg/kg BW, which reduced glucose levels by 11.3%, 12.7%, and 13.9%, respectively. One Way ANOVA analysis showed a p value < 0.05, indicating a significant difference in blood glucose reduction among the concentrations of 96% ethanol extract of nutmeg bark. Conclusion: The 96% ethanol extract of nutmeg bark has been proven to have an antihyperglycemic effect, with the most effective dose at 200 mg/kg BW.Bottom of Form.
Co-Authors Nielma Auliah Nirwana Putri Mastur Prayitno Setiawan Wantry Diasny