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All Journal Jurnal Kesehatan Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Media Kesehatan Politeknik Kesehatan Makassar Borneo Journal Of Pharmascientech Journal of Health Sciences and Medical Development
Nielma Auliah
Universitas Megarezky
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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FORMULASI SEDIAAN MOUTHWASH EKSTRAK ETANOL BUNGAMAWAR MERAH (Rosa damascena Mill) SEBAGAI ANTIBAKTERI TERHADAP Streptococcus mutans Nurfitria Junita; Nielma Auliah; Wantry Diasny
BORNEO JOURNAL OF PHARMASCIENTECH Vol 4 No 2 (2020): Borneo Journal of Pharmascientech
Publisher : Sekolah Tinggi Ilmu Kesehatan Borneo Lestari Banjarbaru

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51817/bjp.v4i2.341

Abstract

It has been conducted a research about Formulation of Red Rose Ethanol Extract ofMouthwash (Rosa damascena Mill) as Antibacterial toward Streptococcus mutans. Thisresearch aim at knowing the activity of Red Rose Ethanol Extract of Mouthwash (Rosadamascena Mill) as Antibacterial toward Streptococcus mutans. In this study, usingexperimental research by formulating the ethanol extract of red rose (Rosa damascena Mill)mouthwash, then tested against Streptococcus mutans bacteria using the agar diffusionmethod. The ethanol extract of red rose (Rosa damascena Mill) mouthwash was prepared inthree concentrations, namely 1%, 3%, 5%, and control solution. The various concentrationswere tested for their antibacterial activity and an evaluation of the Mouthwash byorganoleptic observation, pH and cycling test. Meanwhile, the antibacterial activity test usedagar diffusion method using agar well diffusion. Results of the measurement of the largestaverage inhibition zone at a concentration of 5% of 21.4 mm. Result showed that physicalstability of mouthwash tended to stable on the low temperature storage (4°C) and had aninhibitory level in strong category in obstructing the growth of Streptococcusmutans
MOUTHWASH JUS BUAH NANAS (Ananas comosus L. Merr) TERHADAP BAKTERI Streptococcus mutans Sri Wahyuningsih; Nielma Auliah; Salwi Salwi
Jurnal Kesehatan Vol 13 No 2 (2020): JURNAL KESEHATAN
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v13i2.16423

Abstract

This research aimed to determine the formulation of pineapple juice into mouthwash and to investigate antibacterial activity against Streptococcus mutans. This was an experimental design method, it started by formulating pineapple juice (Ananas comosus L.Merr) into mouthwash and testing the activity of bacteria using the agar diffusion method to determine the inhibition zone. The research result showed that pineapple juice (Ananas comosus L.Merr) can be formulated into mouthwash with a concentration of 5%; 10%; and 15% and there was no significant difference after the stability test. The mouthwash also has antibacterial activity against Streptococcus mutans with a zone of inhibition for a concentration of 5%; 10% and 15%, respectively 8.6 mm; 9.4 mm; and 9.7 mm. Antibacterial activity of pineapple juice mouthwash against Streptococcus mutans showed a moderate inhibition zone category.ABSTRAKPenelitian ini bertujuan untuk mengetahui jus buah nanas dapat diformulasi dalam bentuk sediaan mouthwash dan aktivitas antibakteri mouthwash terhadap bakteri Streptococcus mutans. Penelitian ini termasuk penelitian eksperimental laboratorium dengan memformulasi sediaan dan menguji aktivitas bakteri menggunakan metode difusi agar untuk mengetahui zona hambat sediaan mouthwash jus buah nanas (Ananas comosus L.Merr). Hasil penelitian menunjukkan bahwa jus buah nanas (Ananas comosus L.Merr) dapat diformulasi menjadi sediaan mouthwash dengan konsentrasi 5%; 10%; dan 15% dan tidak terjadi perbedaan signifikan setelah uji kestabilan. Mouthwash juga memiliki aktivitas antibakteri terhadap Streptococcus mutans dengan rata-rata zona hambat untuk konsentrasi 5%; 10% dan 15% masing-masing 8,6 mm; 9,4 mm dan 9,7 mm. Aktivitas antibakteri mouthwash jus buah nanas terhadap bakteri Streptococcus mutans menunjukkan kategori zona hambat sedang.
FORMULASI DAN UJI STABILITAS FISIKA DAN KIMIA SEDIAAN SHAMPO ANTIKETOMBE EKSTRAK KULIT BUAH JERUK PURUT (Citrus hystrix Dc) Nielma Auliah; Muhammad Asri; Sri Wahyuningsih
Media Kesehatan Politeknik Kesehatan Makassar Vol 15, No 2 (2020): Media Kesehatan
Publisher : Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v15i2.1696

Abstract

Penelitian ini bertujuan untuk memformulasikan ekstrak kulit buah jeruk purut (Citrus hystrix Dc.) menjadi sediaan Shampo Antiketombe dengan variasi konsentrasi F1 tanpa ekstrak, F2 5%, F3 10% dan F4 15%. Jenis penelitian ini berupa eksperimen laboratorium dengan pengujian shampo antiketombe meliputi uji stabilitas, Organleptik, Ph, Viskositas dan uji antijamur terhadap jamur Candida albicans. Hasil yang diperoleh yaitu shampo antiketombe dengan konsentrasi 5%, 10%, dan 15% menunjukkan Ph 5,2 – 6,8 dimana memenuhi syarat sediaan shampo yaitu antara 5,0-9,0. Secara organoleptis sediaan shampo antiketombe ekstrak kulit buah jeruk purut menunjukkan tidak ada perubahan bau, warna dan bentuk sebelum dan setelah penyimpanan dipercepat yakni sediaan shampo tetap memiliki bau yang khas, warna coklat hingga coklat tua dan bentuk yang agak kental. Hasil penelitian uji aktivitas antijamur menunjukkan Formulasi shampo antiketombe ekstrak kulit buah jeruk purut dengan konsentrasi 5%, 10%, dan 15% dapat menghambat pertumbuhan jamur Candida albicans dengan respon zona hambat (Kuat-sangat kuat). Dari hasil penelitian yang telah dilakukan, disimpulkan bahwa shampo antiketombe ekstrak kulit buah jeruk purut stabil secara fisika dan kimia untuk penujian organoleptis, Ph, viskositas dan efektif sebagai antiketombe terhadap jamur Candida albicans.
PENGUJIAN ANTI AGING SEDIAAN KRIM CANGKANG BEKICOT (ACHATINA FUNICA) PADA KELINCI (ORYCTOLAGUS CUNICULUS) YANG DIPAPAR SINAR UV Muhammad Asri; Nielma Auliah
Media Kesehatan Politeknik Kesehatan Makassar Vol 14, No 2 (2019): Media Kesehatan
Publisher : Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (194.352 KB) | DOI: 10.32382/medkes.v14i2.1135

Abstract

Snail shells is one of the mollusk phyla that contains protein and chitin function as protector from wind. The protector of wind is a process to prevent premature of the skin. This research aimed to find the formulation and efficacy test of snail shel cream (Achatina fulica) on rabbits (Oryctolagus cuniculus) as protector from the wind .The type of this research used experimental method with UV exposure method using Philips light intensity 10 Mw/cm2 where the back skin of animals try to be wrinkled. The samples of snail shells (Achatina fulica) used the powdered shell is then used as the active compound in the cream dosage formulation. Cracked cream shell powder formulas are formulated in four formulas with concentration  0% (without cracked cream shell powder) 5%, 10%, 15%, and testing the skin of the rabbit’s back (Oryctolagus cuniculus). Treatment is divided into 5 treatments namely treatment 1 as positive control used cream without  active compound, treatment 2 concentration cream 5%, treatment 3 concentration cream 10%, treatment 4 concentration cream 15%, and treatment 5 as negative control used cream patent as the protector of x wind. The result of this research showed the effectivitas of concentration cream 5% which had 16,4 mm, and the positive control had 5,7 mm. It can conclude that with concentration 5% had the most powerful effectiveness than variation in the concentration of other creamsKeywords : Snail shells (Achatina fulica), Formulation, The protector of wind
UJI AKTIVITAS SEDIAAN TEH BIJI MAHONI ( Swietenia mahagoni ) UNTUK MENURUNKAN KADAR GLUKKOSA DAN AKTIVITAS PEROKSIDASI LIPID PADA TIKUS DIABETES MILLITUS TIPE 2 Nielma Auliah; Muhammad Asri
Media Kesehatan Politeknik Kesehatan Makassar Vol 14, No 2 (2019): Media Kesehatan
Publisher : Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (180.423 KB) | DOI: 10.32382/medkes.v14i2.1136

Abstract

This research aimed to know the effect of mahagony seeds ( Swieteniamahagoni ) tea of MDA levels induced type 2 diabetes mellitus alloxan. By using the control group design  method, post-test and by using 15 rats divided into 5 groups, namely group I negative group, group II control Alloxan induction, group III tea mahagony seeds 5 gram/kgBB, group IV tea mahagony seeds 10 gram/kgBB and group V mahagony seeds 15 gram/kgBB. The treatment was carried out for 14 days. In this research showed that the level of blood glucose affects increase of MDA levels. At 15 gram/kgBBof tea dosage presentasionshowed a significant value on decreasing blood glucose levels P = 0,000 < (α 0,05) and blood MDA levels P = 0,000 < (α 0,05) and it can be concluded that mahogany seed tea (Swieteniamahagoni) had an effect on decreasing levels of rat MDA type 2 diabetes mellitus induced by alloxan, with a dose of 15 grams /kgBB which is the optimal dose in reducing blood Glucose and MDA levels. Keywords : Type 2 Diabetes Mellitus, MDA, Mahogany Seeds Tea, Alloxan
SINTESIS NANOPARTIKEL PERAK DENGAN AIR REBUSAN DAUN PEGAGAN (Centella asiatica L.) DAN UJI AKTIVITAS DALAM MENGHAMBAT PERTUMBUHAN BAKTERI Pseudomonas aeruginosa DAN Staphylococcus aureus Indah; Muhammad Asri; Nielma Auliah; Andi Triraparti Ashari
Majalah Farmasi dan Farmakologi Vol. 26 No. 2 (2022): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v26i2.19903

Abstract

Daun pegagan (Centella asiatica L.) mengandung bahan aktif seperti saponin, tanin, flavonoid, steroid serta triterpenoid yang dapat mereduksi ion perak. Penelitian ini bertujuan untuk mengetahui apakah air rebusan daun pegagan dapat digunakan sebagai bioreduktor dalam mensintesis nanopartikel perak serta untuk mengetahui apakah hasil biosintesis daun pegagan memiliki aktivitas daya hambat terhadap bakteri Pseudomonas aeruginosa dan Staphylococcus aureus. Penelitian ini merupakan penelitian eksperimental. Penentuan aktivitas daya hambat terhadap bakteri  Pseudomonas aeruginosa dan Staphylococcus aureus dengan metode difusi cakram. Hasil penelitian menunjukan air rebusan daun pegagan segar dapat digunakan sebagai bioreduktor dalam mensintesis nanopartikel perak yang ditandai dengan adanya puncak serapan pada panjang gelombang 400-500 nm. Ukuran nanopartikel perak yang dihasilkan berkisar 50 s/d 90 nm. Aktivitas antibakteri dari hasil biosintesis memiliki rata-rata  zona hambat 25 mm (sangat kuat) untuk bakteri Pseudomonas aeruginosa dan 22,6 mm (sangat kuat) untuk Staphylococcus aureus. Disimpulkan bahwa daun pegagan dapat mereduksi dan memiliki aktivitas antibakteri terhadap Pseudomonas aeruginosa dan Staphylococcus aureus.
Antioxidant Evaluation of Facial Toner Formulations Containing Ethyl Acetate Fraction from Garcinia Mangostana L. Fruit using ABTS 2,2'-Azinobis 3-ethyl benzothiazoline 6-sulphonic Acid Method Sriyanty Sadsyam; Nielma Auliah; Wa Ode Wisna Anto Uko; Nasrawati Basir; Andi Ulfiana Utari
Journal of Health Sciences and Medical Development Vol. 2 No. 02 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i02.266

Abstract

The mangosteen fruit is rich in polyphenols, particularly xanthones, which have potent antioxidant effects. Given the various effects of facial toners and the growing demand for natural skincare products, mangosteen rind may serve as an alternative ingredient in facial toner formulations. This laboratory experimental study aimed to assess the antioxidant activity of facial toner preparations containing the ethyl acetate fraction of mangosteen rind (Garcinia mangostana L.) using the ABTS method at different concentrations (0.2%, 0.4%, and 0.6%). Four facial toner formulas were formulated, with Formula 1 being the control formula without any active substance and Formulas 2-4 containing the ethyl acetate fraction of mangosteen rind at different concentrations. The prepared formulas underwent physical and chemical stability tests, including organoleptic, homogeneity, pH, viscosity, and humidity tests, before and after six cycles of cycling. The antioxidant activity of the formulas was also evaluated using the ABTS method. The results showed no significant difference (p>0.05) in the organoleptic, viscosity, pH, and humidity tests before and after cycling. Formula 3 showed significant (p<0.05) antioxidant activity compared to the other formulas. Therefore, it can be concluded that the ethyl acetate fraction of mangosteen rind (Garcinia mangostana L.) can be formulated into a facial toner with potent antioxidant activity.
Co-Authors Andi Juaella Yustisi Andi Triraparti Ashari Andi Ulfiana Utari Hana Evangelista Sarambu Indah Lotuconsina, Ari Aprianto Muhammad Asri SR Muhammad Yusuf Nasrawati Basir Nurfitria Junita Salwi Salwi Sri Wahyuningsih Sriyanty Sadsyam Thalib, Muthmainnah Wa Ode Wisna Anto Uko Wantry Diasny