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Efficacy of Cyombopogon Citratus Extract Against Enterococcus Faecalis Permatasari Lahagu, Tessya Nitulo; Huynh Diem An; Cindy Denhara Wijaya; Mellisa Sim
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Biomedical Journal of Indonesia
Publisher : Fakultas Kedokteran Universitas Sriwijaya (Faculty of Medicine, Universitas Sriwijaya) Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.301

Endodontic treatment refers to the act of removing infected pulp tissue and formingand reforming the root canals to prevent bacteria from entering the root canals.Microbial infection in the root canal or in the periapical area is a factor that can leadto failure of root canal treatments. Endodontic treatment failure can be caused thebacteria Enterococcus faecalis. The irrigation agent commonly used is sodiumhypochlorite. Sodium hypochlorite in large concentrations can be toxic to tissues.Lemongrass plant (Cymbopogon citratus) is a natural ingredient that can be used asan antibacterial agent. The aims of study to determine the comparison of theantibacterial effectiveness of lemongrass plant extracts (Cyombopogon citratus (DC).Staph) concentrations of 25%, 50%, 75%, 100% with 2.5% sodium hypochlorite ininhibiting the growth of the bacterium Enterococcus faecalis. Lemongrass plantextracts Cyombopogon citratus (DC). Staph) made by maceration method andconverted into 25%, 50%, 75%, and 100%. The bacterial test method used the agardiffusion test (Kirby-Bauer test) to see the effectiveness of antibacterialsThe result ofthe one way ANOVA statistical test resulted in significance value of p=0,001 (p<0,05)so that means there was differences in the average diameter of inhibitory lemongrassplant extracts (Cyombopogon citratus (DC). Staph) concentrations of 25%, 50%,75%, 100% with 2.5% sodium hypochlorite in inhibiting the growth of the bacteriumthe results are 13.68 Â± 1.34 mm, 16.08 Â± 0.87 mm, 16.33 Â± 0.35 mm, 17.78 Â± 0.93mm and 7.83 Â± 0.44 mm and reinforced by the posthoc Tukey HSD test. Theconclusion from the study that there is a difference between the antibacterialeffectiveness of lemongrass plant extract (Cyombopogon citratus (DC). Staph)concentrations of 25%, 50%, 75% and 100% with 2.5% sodium hypochlorite ininhibiting the growth of the bacterium Enterococcus faecalis.

Incidence of Hard Tissue Disease on Periapical Radiographic Examination at Prima Oral Dental Hospital Medan Indonesia Andre Yonathan Purba; Mellisa Sim; Putra, Phimatra Jaya
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.481

Background. Caries is a chronic infection of dental hard tissue. The development of caries is not limited to the tooth area, but caries can progress to the pulp chamber resulting in periapical lesions and abnormalities if not treated. Early detection of oral disease through radiographic examination is important, one of which is through periapical radiography. Methods. This type of research is descriptive. The sample of this research is periapical radiography of cases of hard tissue disease at Prima Oral Dental Hospital period April – May 2021 as many as 78 photos. Sampling in this study was done by random sampling. Data were analyzed descriptively. Results. Based on the interpretation of 78 photos periapical radiographs, it was found that the highest number of caries cases at Prima Oral Dental Hospital was superficial caries as much as 48.7%, followed by media caries as much as 43.6% and profunda caries only 7.7%. The mean and standard deviation of superficial caries depth was 3.51±1.348; medium caries 6.88±1.122 and profunda caries 10.00±1.549. Conclusion. Superficial caries is the most caries case found on periapical radiographic examination at Prima Oral Dental Hospital, while profunda caries is the least caries case.

Antibacterial Effectiveness of Rambutan Peel Extract (Nephelium lappaceum L.) in Inhibiting the Growth of Enterococcus Faecalis Bacteria Wijaya, Cindy Denhara; Rajindervir Singh; Mellisa Sim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.487

Backgrounds. This research is a study that seeks to explore the potential of rambutan extract in inhibiting the growth of Enterococcus faecalis bacteria, where this bacterium is one of the bacteria that is often found in the oral cavity and often causes infections and dental and oral problems. Methods. This research is an experimental study in vitro. This study aims to determine the diameter of the inhibition zone of rambutan peel extract on Enterococcus faecalis. Rambutan peel extracts were tested at levels of 5%, 7.5% and 10% with NaOCl (Sodium Hypochlorite) 2.5% control, where each test group was tested on 6 culture plates of Enterococcus faecalis bacteria. Results. The 10% rambutan peel extract group had the highest inhibition zone diameter of 12.4 ± 1.21 mm. Rambutan peel extract 5% - 10% showed a higher inhibition zone diameter than the control NaOCl 2.5%. The results of the effectiveness test of the diameter of the inhibition zone between the test groups. Rambutan peel extracts 5%, 7.5% and 10% showed different levels of inhibition zone diameter compared to 2.5% NaOCl. Rambutan peel extract 5%, 7.5%, and 10% had a higher diameter of the inhibition zone than the 2.5% NaOCl control. Conclusion. Rambutan peel extract 5%, 7.5% and 10% were more effective in inhibiting the growth of Enterococcus faecalis than control NaOCl.

The Effectiveness of Turmeric Extract (Curcuma domestica Val.) Against Fibroblast Cells in Socket Post Tooth Extraction Lokanata, Shieny; Sendyra Utama; Mellisa Sim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.490

Background. This study is an exploration to assess the potential of turmeric extract in the induction of fibroblast cell proliferation, where fibroblast cells are important cells in the process of repair and healing of wounds (socket wounds after tooth extraction). The antioxidants found in turmeric extract are believed to have potential in the initiation of growth factors which will then initiate the process of fibroblast cell activation, which in turn will play a role in wound healing. Methods. The research design in this study is an experimental study with a post-test-only approach with a control group design. The research subjects in this study were rats (Rattus norvegicus) Wistar strain, male sex, age 8-12 weeks, and body weight between 150-250 grams. A total of 30 white rats were grouped into 5 groups. Data analysis was carried out with the help of SPSS 25 software. First, a univariate analysis was performed to present the mean number of fibroblast cells and the standard deviation. Furthermore, an analysis was carried out to assess the difference in the mean number of fibroblast cells between groups using the one-way ANOVA test. Results. The results of the one-way ANOVA test showed that there were significant differences between the test groups. Giving 10% and 15% turmeric extract was seen to be more potent in the initiation of the number of fibroblast cells than the treatment group that received povidone-iodine. Conclusion. Turmeric extract (Curcuma domestica Val.) concentration of 15% was the most effective concentration as an effort to increase the number of fibroblast cells after tooth extraction in Wistar rats.

Incidence of Hard Tissue Disease on Periapical Radiographic Examination at Prima Oral Dental Hospital Medan Indonesia Andre Yonathan Purba; Mellisa Sim; Putra, Phimatra Jaya
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.481

Background. Caries is a chronic infection of dental hard tissue. The development of caries is not limited to the tooth area, but caries can progress to the pulp chamber resulting in periapical lesions and abnormalities if not treated. Early detection of oral disease through radiographic examination is important, one of which is through periapical radiography. Methods. This type of research is descriptive. The sample of this research is periapical radiography of cases of hard tissue disease at Prima Oral Dental Hospital period April – May 2021 as many as 78 photos. Sampling in this study was done by random sampling. Data were analyzed descriptively. Results. Based on the interpretation of 78 photos periapical radiographs, it was found that the highest number of caries cases at Prima Oral Dental Hospital was superficial caries as much as 48.7%, followed by media caries as much as 43.6% and profunda caries only 7.7%. The mean and standard deviation of superficial caries depth was 3.51±1.348; medium caries 6.88±1.122 and profunda caries 10.00±1.549. Conclusion. Superficial caries is the most caries case found on periapical radiographic examination at Prima Oral Dental Hospital, while profunda caries is the least caries case.

Antibacterial Effectiveness of Rambutan Peel Extract (Nephelium lappaceum L.) in Inhibiting the Growth of Enterococcus Faecalis Bacteria Wijaya, Cindy Denhara; Rajindervir Singh; Mellisa Sim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.487

Backgrounds. This research is a study that seeks to explore the potential of rambutan extract in inhibiting the growth of Enterococcus faecalis bacteria, where this bacterium is one of the bacteria that is often found in the oral cavity and often causes infections and dental and oral problems. Methods. This research is an experimental study in vitro. This study aims to determine the diameter of the inhibition zone of rambutan peel extract on Enterococcus faecalis. Rambutan peel extracts were tested at levels of 5%, 7.5% and 10% with NaOCl (Sodium Hypochlorite) 2.5% control, where each test group was tested on 6 culture plates of Enterococcus faecalis bacteria. Results. The 10% rambutan peel extract group had the highest inhibition zone diameter of 12.4 ± 1.21 mm. Rambutan peel extract 5% - 10% showed a higher inhibition zone diameter than the control NaOCl 2.5%. The results of the effectiveness test of the diameter of the inhibition zone between the test groups. Rambutan peel extracts 5%, 7.5% and 10% showed different levels of inhibition zone diameter compared to 2.5% NaOCl. Rambutan peel extract 5%, 7.5%, and 10% had a higher diameter of the inhibition zone than the 2.5% NaOCl control. Conclusion. Rambutan peel extract 5%, 7.5% and 10% were more effective in inhibiting the growth of Enterococcus faecalis than control NaOCl.

The Effectiveness of Turmeric Extract (Curcuma domestica Val.) Against Fibroblast Cells in Socket Post Tooth Extraction Lokanata, Shieny; Sendyra Utama; Mellisa Sim
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.490

Background. This study is an exploration to assess the potential of turmeric extract in the induction of fibroblast cell proliferation, where fibroblast cells are important cells in the process of repair and healing of wounds (socket wounds after tooth extraction). The antioxidants found in turmeric extract are believed to have potential in the initiation of growth factors which will then initiate the process of fibroblast cell activation, which in turn will play a role in wound healing. Methods. The research design in this study is an experimental study with a post-test-only approach with a control group design. The research subjects in this study were rats (Rattus norvegicus) Wistar strain, male sex, age 8-12 weeks, and body weight between 150-250 grams. A total of 30 white rats were grouped into 5 groups. Data analysis was carried out with the help of SPSS 25 software. First, a univariate analysis was performed to present the mean number of fibroblast cells and the standard deviation. Furthermore, an analysis was carried out to assess the difference in the mean number of fibroblast cells between groups using the one-way ANOVA test. Results. The results of the one-way ANOVA test showed that there were significant differences between the test groups. Giving 10% and 15% turmeric extract was seen to be more potent in the initiation of the number of fibroblast cells than the treatment group that received povidone-iodine. Conclusion. Turmeric extract (Curcuma domestica Val.) concentration of 15% was the most effective concentration as an effort to increase the number of fibroblast cells after tooth extraction in Wistar rats.

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