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Yusuf, Franky
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Dentistry Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health

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Peningkatan Ekspresi PD-L1 pada Squamous Cell Carcinoma Nasofaring Tipe Undifferentiated Non Keratinizing Yusuf, Franky; Prasetyo, Awal; Karlowee, Vega; Astuti, Meira Dewi Kusuma; Nur, Rizki Widya
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (500.974 KB) | DOI: 10.36408/mhjcm.v8i2.579

Abstract

Increased Expression of PD-L1 in Undifferentiated Non Keratinizing Squamous Cell Carcinoma Nasopharynx ABSTRACT BACKGROUND: PD-L1 expressed by tumor cells in nasopharyngeal carcinoma (NPC) can be used by tumor cells to avoid the patient's immune system. This can affect prognosis such as age, gender, histopathological type, tumor stage and quality of life through immunosuppressive activity. PD-L1 expression is expected to be a biomarker for prognostic factor assessment and immunotherapy. OBJECTIVE: To determine whether there is a relationship between the level of PD-L1 expression and prognostic factors in NPC. METHODS: This is analytic observational study with a cross-sectional design. PD-L1 expression was examined immunohistochemically using 61 samples of paraffin block, which had been diagnosed as NPC in the Laboratory of Anatomical Pathology, Dr. Kariadi from January 2017 to June 2020. Patient clinical data were used as prognostic factors, namely age, gender, histopathological type, tumor stage and quality of life. Analysis was performed with the Chi-Square test to determine the relationship between the level of PD-L1 expression and prognostic factors. RESULTS: There was a significant correlation between PD-L1expression in tumor cells and histopathological type (p=0.001). No significant correlation between PD-L1 expression and age (p=0.405), gender (p=0.241), tumor stage (p=0.928) and quality of life (p=0.103). CONCLUSION: PD-L1 expression in this study cannot be used as a prognostic factor in NPC patients, although the histopathological type shows a significant relationship, so further research is needed with a larger sample and a longer period. Keywords: Nasopharyngeal carcinoma; PD-L1; prognostic factor
PERTANGGUNGJAWABAN HUKUM TERKAIT PENGELOLAAN LIMBAH B3 DALAM FASILITAS KESEHATAN Yusuf, Franky
JOURNAL IURIS SCIENTIA Vol. 2 No. 1 (2024): JOURNAL IURIS SCIENTIA
Publisher : Yayasan Merassa Indonesia Publikasi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62263/jis.v2i1.31

Abstract

Tujuan dari penelitian ini adalah untuk melihat bagaimana pertanggungjawaban pidana perusahaan yang diwujudkan dalam bentuk rumah sakit dan/atau rumah sakit darurat sehubungan dengan tindak pidana pembuangan limbah medis padat pada masa pandemi Covid-19, dan untuk mengetahui faktor-faktor yang mempengaruhi pertanggungjawaban pidana ini. Kesimpulan yang didapatkan adalah perusahaan dan pejabat administrasi yang memberi perintah untuk melakukan tindak pidana dapat dimintai pertanggungjawaban pidana. Beberapa faktor dapat mempengaruhi terwujudnya pertanggungjawaban pidana yaitu pengawasan yang kurang optimal oleh aparat penegak hukum, ketentuan yang tidak jelas terutama terkait dengan akomodasi rumah sakit darurat, yang membutuhkan pembaharuan undang-undang. The aim of this paper is to see how corporate criminal liability is realized in the form of hospitals and/or emergency hospitals in connection with criminal acts of disposal of solid medical waste during the Covid-19 pandemic, and to determine the factors that influence this criminal liability. The conclusion obtained is that companies and administrative officials who give orders to commit criminal acts can be held criminally responsible. Several factors can influence the realization of criminal liability, namely less than optimal supervision by law enforcement officials, unclear provisions, especially those related to emergency hospital accommodation, which requires legislative updates.
Co-Authors Astuti, Meira Dewi Kusuma Awal Prasetyo Karlowee, Vega Nur, Rizki Widya