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Astuti, Meira Dewi Kusuma
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Peningkatan Ekspresi PD-L1 pada Squamous Cell Carcinoma Nasofaring Tipe Undifferentiated Non Keratinizing Yusuf, Franky; Prasetyo, Awal; Karlowee, Vega; Astuti, Meira Dewi Kusuma; Nur, Rizki Widya
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (500.974 KB) | DOI: 10.36408/mhjcm.v8i2.579

Abstract

Increased Expression of PD-L1 in Undifferentiated Non Keratinizing Squamous Cell Carcinoma Nasopharynx ABSTRACT BACKGROUND: PD-L1 expressed by tumor cells in nasopharyngeal carcinoma (NPC) can be used by tumor cells to avoid the patient's immune system. This can affect prognosis such as age, gender, histopathological type, tumor stage and quality of life through immunosuppressive activity. PD-L1 expression is expected to be a biomarker for prognostic factor assessment and immunotherapy. OBJECTIVE: To determine whether there is a relationship between the level of PD-L1 expression and prognostic factors in NPC. METHODS: This is analytic observational study with a cross-sectional design. PD-L1 expression was examined immunohistochemically using 61 samples of paraffin block, which had been diagnosed as NPC in the Laboratory of Anatomical Pathology, Dr. Kariadi from January 2017 to June 2020. Patient clinical data were used as prognostic factors, namely age, gender, histopathological type, tumor stage and quality of life. Analysis was performed with the Chi-Square test to determine the relationship between the level of PD-L1 expression and prognostic factors. RESULTS: There was a significant correlation between PD-L1expression in tumor cells and histopathological type (p=0.001). No significant correlation between PD-L1 expression and age (p=0.405), gender (p=0.241), tumor stage (p=0.928) and quality of life (p=0.103). CONCLUSION: PD-L1 expression in this study cannot be used as a prognostic factor in NPC patients, although the histopathological type shows a significant relationship, so further research is needed with a larger sample and a longer period. Keywords: Nasopharyngeal carcinoma; PD-L1; prognostic factor
Correlation Between Testosterone Level With HBA1C Level As Glycemic Control Marker Among Type 2 Diabetes Mellitus Patient Halim, Fenny; Listiana, Devia Eka; Karlowee, Vega; Istiadi, Hermawan; Prasetyo, Awal; Astuti, Meira Dewi Kusuma
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.959

Abstract

BACKGROUND: Helicobacter pylori is classified as a grade 1 carcinogen by the International Agency for Research on Cancer. Identification of Helicobacter pylori infection is crucial for the prevention of malignancy. Immunohistochemistry is more specific and sensitive than modified Giemsa because it based on the antigen- antibody binding so it can exclude other organisms. However, it can be expressed in all species of Helicobacter genus. OBJECTIVE: To compare the identification methods of Helicobacter spp in stomach biopsy between modified Giemsa and immunohistochemistry. METHOD: This research was a cross-sectional study. There were 64 biopsies taken by simple random sampling. They consisted of 32 positive and 32 negative Helicobacter spp based on the interpretation of modified Giemsa. Statistical analysis using x2 test. RESULT: The number of atypical Helicobacter spp was 42.%. The number of samples that received Proton Pump Inhibitor (PPI) therapy was 93.75%. Helicobacter spp was positive in 31 samples and negative in 33 samples based on the interpretation of immunohistochemistry staining. There was no significant difference (p=0.617) between the identification results of Helicobacter spp using immunohistochemistry compared to the Modified Giemsa at both 400x and 1000x magnification. CONCLUSION: Modified Giemsa is still reliable for identifying Helicobacter spp, especially in classical form, compared to immunohistochemistry. Due to the administration of PPI, there are a lot of cases with atypical form of Helicobacter spp which can be differentiated into coccoid form and intraepithelial located. Immunohistochemistry staining is useful in identify these cases.
Neonates with epidermolysis bullosa simplex: a case series Amalia, Fitri; Wistiani, Wistiani; Astuti, Meira Dewi Kusuma; Rahmat, Yosep Ferdinand
Paediatrica Indonesiana Vol. 65 No. 2 (2025): March 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.2.2025.164-70

Abstract

Epidermolysis bullosa is a rare and currently incurable inherited disorders characterized by mechanical fragility of affected tissues which can be fatal. We describe two cases of neonatal Epidermolisis bullosa followed in the high risk neonates ward. The first case presented with bulla at one day after birth with amniotic band syndrome and the second case presented with bulla right after birth with neonatal infection. Keyword: epidermolysis bullosa simplex, neonates
Co-Authors Awal Prasetyo Devia Eka Listiana, Devia Eka Fitri Amalia Halim, Fenny Hermawan Istiadi Karlowee, Vega Nur, Rizki Widya Rahmat, Yosep Ferdinand Wistiani Wistiani Yusuf, Franky