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All Journal Indian Journal of Forensic Medicine & Toxicology
Omar A. M. Al-Habib
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Public Health

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Bronchodilator Effect of Crataegus azarolus var aronia Unripped Fruit Extracts on Rat’s Tracheal Smooth Muscle Aveen A. Mohammed; Omar A. M. Al-Habib
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.16807

Abstract

Objectives: The present study aimed to investigate the bronchodilator effect of different Crataegus azarolusvar aronia unripped fruit extracts on tracheal smooth muscle of rats and to study the roles of K channels andEDHFs in produced responses.Background: Crataegus is widely used in Kurdistan Region for the prevention of several diseases suchas respiratory, cardiovascular, hypertension …. etc. due to its content of several bioactive compounds likearomatic amines, phenolic acid, flavonoids, and proanthocyanidins.Method: The bronchodilator effects of various Crataegus fruit’s extracts on rat’s tracheal rings and the rolesof K+, Ca2+ channels and EDHFs in bronchodilation using specific blockers.Results: Most of Crataegus fruit’s extracts used showed a potent bronchodilator effect on trachea, in whichthe HME produced a highly significant dilation, followed by methanol and ethyl acetate extracts whichshowed a considerable relaxant effect. The results confirmed that the induced dilation was NO and PGI2dependent, along with activations of KATP and Kir and Kca while Kv plays a minor and limited role.Conclusion: The novel results indicate that HM, M, EA extracts prepared from Crataegus unripped fruitproduce a potent bronchodilator effect, which was NO and PGl2 dependent along with the activation of KATP,Kir and Kca2+ channels.
The Role of K and Ca Channels in Hydrogen Sulfide Induced Relaxation in Arteries Feeding Human Colorectal Cancer Kamaran. H. Mohammed; Omar A. M. Al-Habib; Sardar H. Arif
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17572

Abstract

This study was designed to find out the vasorelaxant effects of hydrogen sulfide (H2S) on arteries feedinghuman colon cancer. In addition, it also included the study of the possible roles of potassium (K+) andcalcium (Ca2+) channel types in H2S-induced relaxation in the isolated arteries. Sodium sulfide (Na2S)showed a potent dose-dependent relaxant effect on Norepinephrine (1X10-5 M) precontracted arteries.The use of different specific K+ channel blockers (BaCl2, 4-AP, GLIB, and TEA) individually indicatedH2S-induced relaxation was affected by all K channel types participated to a various extent, except Kvchannels. Both Kca2+ and Kir channels played a major role in the induced relaxation, while KATP playeda minor and non-significant role. On the other hand, Kv channel played no direct role, and the inducedresponse curve was very close to that of the control. Possible combinations of K channel blockersshowed that some produced synergistic effect to different extent, whereas others produced mild andnon-significant effect except at the highest doses used on dose-response curves. Thus, combinations of(GLIB+4-AP), (GLIB+BaCl2) and (BaCl2+TEA) caused a highly significant blocking in the inducedresponse curve, while (BaCl2 +4-AP) and (TEA+4-AP) produced a mild inhibition except at the highestdoses used in which the inhibition was significant.
The Effect of Iron Nanoparticles (FeNPs) on Some Biological and Hematological Parameters in Albino Rats Dilsher. A. Mohammed; Omar A. M. Al-Habib
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15727

Abstract

Background: Nowadays, iron nanoparticles and other nanomaterials are widely used in many fields including industrial and biomedical fields. Yet many concerns remain about their fate and toxicity to living organisms. Objective: The aim of the current study was to evaluate the risk of using iron oxide nanomaterials as food additives for animals to increase its utilization compared to bulk size particles of the same material. Materials and Methods: The study included the effect of two different nano-sized iron oxides (25 nm and 50 nm) at two doses (1 mg/kg feed and 10 mg/kg feed) on some biological and hematological parameters in male albino rats. Results: The results indicate that rat’s performance, growth, feed conversion rates were not affected with no sign of toxicity. Most of the hematological parameters in all treated groups were not affected by IONPs except one group which showed a significant difference in the percent of granulocytes compared with the control. Conclusion: It can be concluded that iron oxide NPs of different sizes and doses did not affect their performance, growth rate, hematological parameters with no sign of toxicity.
Co-Authors Aveen A. Mohammed Dilsher. A. Mohammed Kamaran. H. Mohammed Sardar H. Arif