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All Journal Indian Journal of Forensic Medicine & Toxicology
Sardar H. Arif
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Public Health

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The Role of K and Ca Channels in Hydrogen Sulfide Induced Relaxation in Arteries Feeding Human Colorectal Cancer Kamaran. H. Mohammed; Omar A. M. Al-Habib; Sardar H. Arif
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 1 (2022): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i1.17572

Abstract

This study was designed to find out the vasorelaxant effects of hydrogen sulfide (H2S) on arteries feedinghuman colon cancer. In addition, it also included the study of the possible roles of potassium (K+) andcalcium (Ca2+) channel types in H2S-induced relaxation in the isolated arteries. Sodium sulfide (Na2S)showed a potent dose-dependent relaxant effect on Norepinephrine (1X10-5 M) precontracted arteries.The use of different specific K+ channel blockers (BaCl2, 4-AP, GLIB, and TEA) individually indicatedH2S-induced relaxation was affected by all K channel types participated to a various extent, except Kvchannels. Both Kca2+ and Kir channels played a major role in the induced relaxation, while KATP playeda minor and non-significant role. On the other hand, Kv channel played no direct role, and the inducedresponse curve was very close to that of the control. Possible combinations of K channel blockersshowed that some produced synergistic effect to different extent, whereas others produced mild andnon-significant effect except at the highest doses used on dose-response curves. Thus, combinations of(GLIB+4-AP), (GLIB+BaCl2) and (BaCl2+TEA) caused a highly significant blocking in the inducedresponse curve, while (BaCl2 +4-AP) and (TEA+4-AP) produced a mild inhibition except at the highestdoses used in which the inhibition was significant.
Co-Authors Kamaran. H. Mohammed Omar A. M. Al-Habib