<![CDATA[This study was designed to find out the vasorelaxant effects of hydrogen sulfide (H2S) on arteries feedinghuman colon cancer. In addition, it also included the study of the possible roles of potassium (K+) andcalcium (Ca2+) channel types in H2S-induced relaxation in the isolated arteries. Sodium sulfide (Na2S)showed a potent dose-dependent relaxant effect on Norepinephrine (1X10-5 M) precontracted arteries.The use of different specific K+ channel blockers (BaCl2, 4-AP, GLIB, and TEA) individually indicatedH2S-induced relaxation was affected by all K channel types participated to a various extent, except Kvchannels. Both Kca2+ and Kir channels played a major role in the induced relaxation, while KATP playeda minor and non-significant role. On the other hand, Kv channel played no direct role, and the inducedresponse curve was very close to that of the control. Possible combinations of K channel blockersshowed that some produced synergistic effect to different extent, whereas others produced mild andnon-significant effect except at the highest doses used on dose-response curves. Thus, combinations of(GLIB+4-AP), (GLIB+BaCl2) and (BaCl2+TEA) caused a highly significant blocking in the inducedresponse curve, while (BaCl2 +4-AP) and (TEA+4-AP) produced a mild inhibition except at the highestdoses used in which the inhibition was significant.]]>
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