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All Journal Indian Journal of Forensic Medicine & Toxicology
Supakit Khacha-Ananda
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Decreased Antioxidant Capacity in Corn Farmers Occupationally Exposed to the Mixture of Herbicides Unchisa Intayoung; Kanyapak Kohsuwan; Klintean Wunnapuk; Ratana Sapbamrer; Supakit Khacha-Ananda
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 4 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i4.17121

Abstract

Background: The application of herbicides has been a common practice in worldwide agriculture, mainlywith the goal to increase efficacy of weed control. So, most farmers faced a greater risk of herbicideexposure to develop adverse health effects from oxidative stress-induced herbicides. The aim of this studyis to determine the urinary total antioxidant capacity (TAC) and 8-isoprostane levels in farmers using themixture of herbicides in Long District, Phrae Province, Thailand.Methods: Ninety-three participants were recruited. The spot urine samples (pre- and post-work) werecollected. The urinary TAC was determined using ABTS radical scavenging assay. The urinary 8-isoprostanelevel was investigated by commercial ELISA kit.Results: Most farmers worked on a farm during 1-5 h/day. Fifty-five percents of participants used themixture of herbicide while working between glyphosate and paraquat as well as glyphosate and 2,4-D. Theurinary TAC levels in pre-work urine sample of farmers applied combining herbicides were significantlyhigher than that level in their post-work urine sample. However, there was no significant difference betweenpre- and post-work urinary 8-isoprostane in farmers applied combining herbicides.Conclusion: The results suggest that occupational exposure to mixture of glyphosate herbicides plus paraquator 2,4-D could induce abnormal oxidative stress value especially antioxidant defense among agriculturalworkers.
Haplotype Profiling of Y-STRs among Northern Population in Thailand Supakit Khacha-ananda; Phatcharin Mahawong; Thida Kaewkod
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14450

Abstract

Background: The investigation of Y-short tandem repeats (Y-STRs) has been widely performed in forensiccaseworks. Due to variation between populations, understanding of genetic information within individual apopulation could provide the database and scientifically reliable results. This study was to investigate alleleand haplotype frequencies of Y-STRs among localized people who lived in northern Thailand.Methods: A retrospective descriptive study was conducted by gathering medical reports of Y-STRs typing.The allele frequency and gene diversity as well as haplotype frequency and diversity were calculated.Pairwise genetic distance (Rst) was also calculated based on haplotype pattern by using AMOVA andMultidimensional Scaling (MDS) tools.Results: The result showed that DYS389II, DYS439, and DYS392 represented the highest number of allelepatterns. The highest and lowest allele frequency was found to be allele 14 of DYS437 and allele 13 ofDYS437, respectively. The highest and lowest gene diversity was observed in DYS389II and DYS437,respectively. One-hundred and sixty different haplotypes were defined where 144 carried a unique haplotypeand 16 carried a replicate haplotype. A significant Rst value was obtained between the studied population andcentral Thai population.Conclusion: This study provided genetic database of Y-STRs among localized population in northern regionof Thailand. The genetic structure of our subjects also represented the significant close relationship withsome other populations in Southeast Asia.
Allele Frequencies and Forensic Statistical Parameters for 21 Autosomal Short Tandem Repeats (STRs) loci in Northern Thai Population Supakit Khacha-ananda; Yutti Amornlertwatana; Phatcharin Mahawong; Nitaya Khamkomkai
Indian Journal of Forensic Medicine & Toxicology Vol. 16 No. 3 (2022): Indian Journal of Forensic Medicine and Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v16i3.18310

Abstract

Background: Although the genetic information of STRs has been established over the entire world, the differentcharacteristics between populations influenced the STRs information. FBI’s guideline recommended to expandadditional number of STRs loci to increase power of discrimination and exclusion. Unfortunately, the currentdata of STRs in northern Thai population have not fully covered additional loci. The aim of this study is to obtainaccurate allele frequencies of STRs among northern Thai population.Methods: The genetic profiles ofunrelated individuals were characterized by Investigator 24 plex Go kit. Allelefrequencies and forensic statistical parameters were calculated within GenoProof®3and Arlequin ver 3.5.2.2.Results: The SE33 and TH01 loci represented largest and lowest number of different alleles, respectively. Therewas no significant deviation from the Hardy–Weinberg equilibrium (HWE) after Bonferroni correction in all loci(p=0.002). The SE33 locus showed the greatest PD and PE, whereas the TPOX represented the lowest PD and PE.The studied population (northern Thai) appear to be most closely related to previously reported populationscontaining of Chinese, Japanese, and Vietnamese based on allele frequency.Conclusion: Our results recommended that current autosomal STRs data extended the application of STRs typingin parentage analyses and human identification among the localized population in northern region of Thailanddue to highly informative polymorphic data.
Co-Authors Kanyapak Kohsuwan Klintean Wunnapuk Nitaya Khamkomkai Phatcharin Mahawong Ratana Sapbamrer Thida Kaewkod Unchisa Intayoung Yutti Amornlertwatana