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All Journal Chemistry Indonesian Journal of Chemical Research Jurnal Adiguna Pengabdian Masyarakat
Seulina Panjaitan, Riong
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Biochemistry, Genetics & Molecular Biology Chemistry Engineering Environmental Science Social Sciences Other

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Study of Molecular Docking of Alkaloid Derivative Compounds from Stem Karamunting (Rhodomyrtus tomentosa) Against α-glucosidase Enzymes mulyati, Budi; Seulina Panjaitan, Riong
Indonesian Journal of Chemical Research Vol 9 No 2 (2021): Edition for September 2021
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2021.9-bud

Abstract

Karamunting plant (Rhodomyrtus tomentosa) is a traditional medicinal plant. The leaves, roots, stems, and fruits of Karamunting have been identified, and their biological activities are antioxidants, antibacterial, antidiabetic, anti-inflammatory, and anticancer that contained alkaloids, tannins, and flavonoids. The types of alkaloids found in karamunting stems are homolycorine, ismine, lycorine, maritidine and tazetine. This study aims to determine the binding score of alkaloid-derived compounds with protein α-glucosidase and determine the protein's active site bound to the ligand. The method used in this research is Protein-Ligand ANT-System (PLANTS). The results showed that the anchoring score of homolycorine was -60.83 kcal/mol, ismine -64.42 kcal/mol, lycorine -71.20 kcal/mol, maritidine -61.82 kcal/mol, and tazetine -65.02 kcal/mol. The active sites used for binding are Glu526, Gly555, and Pro556. The average score for anchoring alkaloid-derived compounds with protein α-glucosidase is 83.84%. This number indicates that karamunting stems can be used as antidiabetic.
Webinar Sosialisasi Vaksinasi Hepatitis B Pada Forum Mahasiswa Kepulauan Seribu, Jakarta Utara, Indonesia Seulina Panjaitan, Riong; Purwati, Purwati; Sutriningsih, Sutriningsih; Sagala, Zuraida; Lailatusaadah, Nuke; Clara, Clara; Angely Septihany, Elisabeth
Jurnal Adiguna Pengabdian Masyarakat Vol 1 No 1 (2024): Jurnal Adiguna Pengabdian Masyarakat Juli 2024
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/japm.v1i1.17

Abstract

Viral hepatitis is an infectious disease that is a public health problem in developing countries around the world, including Indonesia. Viral hepatitis can affect the morbidity rate. Hepatitis B is caused by the Hepatitis B virus (HBV). Hepatitis B can be prevented with a safe and effective vaccine that is currently available. The purpose of this community service activity is to provide knowledge to the Thousand Islands Student Forum regarding the definition of Hepatitis B disease, the types of Hepatitis B disease and its causes. In addition, we conducted a socialization activity regarding hepatitis vaccination as a form of prevention effort against Hepatitis B disease. The method used by community service members is the presentation method with the help of powerpoint slides through the google meet application. This activity involved the participation of students from the Morning Pharmaceutical Biotechnology class B, Even Academic Year 2020/2021 and the Thousand Islands Student Forum. The results achieved were increasing knowledge to the Thousand Islands Student Forum about Hepatitis B disease and the Hepatitis B vaccine as seen from the results of throwing questions to the committee. The benefits obtained from this activity such as providing more knowledge and educating the Thousand Islands Student Forum about various types of Hepatitis B vaccines for routine immunization programs as a preventive measure against Hepatitis B disease.
Co-Authors Angely Septihany, Elisabeth Budi Mulyati, Budi Clara, Clara Lailatusaadah, Nuke Purwati Purwati Sagala, Zuraida Sutriningsih, Sutriningsih