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All Journal Journal of Experimental and Clinical Pharmacy (JECP) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Yusuf, Siti Salma
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Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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UJI AKTIVITAS EKSTRAK DAUN SECANG (Caesalpinia sappan L) TERHADAP PERTUMBUHAN BAKTERI ESCHERICHIA COLI Aba, Nurulvalia M; Hidayat, Muh; Yusuf, Siti Salma
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 2 (2021): Agustus, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i2.239

Abstract

Tanaman Secang (Caesalpinia Sappan L) merupakan tanaman tradisional berasal dari Suku Caesalpiniaceae yang dipercaya oleh masyarakat dapat mengobati batuk berdarah, diare, darah kotor, penawar racun, dan gangguan sirkulasi darah. Penyelidikan fitokimia mengungkapkan bahwa ekstrak daun secang terdapat kandungan senyawa kimia di dalamnya terdapat senyawa saponin dan flavonoid. Penelitian dilakukan untuk memahami kemampuan antibakteri dari ekstrak daun secang Caesalpinia sappan L dalam menghambat perkembangan Eschericia coli. Metode uji aktivitas antibakteri yang digunakan adalah Penelitian ini dilakukan dengan menggunakan metode difusi agar. Metode ekstraksi dilakukan yaitu maserasi dengan pelarut etanol 70%. Hasil menunjukan bahwa daun secang memiliki sifat antibakteri terhadap Eschericia coli dengan zona hambat pada variasi konsentrasi ekstrak yang digunakan yaitu 20%,40% dan 80% berturut-turut adalah 34,53 mm, 29,83 mm, dan 32,63 mm. Kesimpulan, ekstrak etanol daun secang mempunyai daya hambat sangat kuat pada konsentrasi 20% yaitu 34,53 mm terhadap pertumbuhan Eschericia coli.Kata Kunci: Tanaman Secang, antibakteri, Eschericia coli 
The effect of co-chemotherapy of ethyl acetate fraction of Long jack roots (Eurycoma longifolia jack) on interleukin-6 expression of 7,12- dimethylbenz anthrasen breast carcinoma model Siti Salma Yusuf; Laela Hayu Nurani; Sitarina Widyarini
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 2, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss2.art7

Abstract

Background: Carcinogenic compound can cause cancer, one of which is 7,12- Dimethylbenz anthrasen (DMBA). Therapy used is chemotherapy using doxorubicin. However, doxorubicin can cause side effects and not specific enough, so it can also impair normal cells and cause resistance, so Long jack roots are needed as co- chemotherapy agent.Objective: To assess the effect of giving co-chemotherapy ethyl acetate fraction of Long jack roots and doxorubicin on the development of breast cancer through inhibition interleukin-6 expression.Methods: A total of 35 female rats SD strain were divided into 5 intervention group, each group contained 7 rats, namely Group 1 (baseline given feed and water), Group 2 (DMBA 20 mg / kg given 2x a week for 5 weeks), Group 3 (DMBA 20mg / kg + Long jack roots Ethyl acetate fraction 100 mg / kg), Group 4 (DMBA 20 mg / kg + Doxorubicin 1,17mg / kg), Group 5 (DMBA 20 mg / kg + Long jack roots ethyl acetate fraction 100 mg / kg + Doxorubicin 1,17mg / kg), then on the 16th week, surgery was done to remove animal’s mammae and organs and to conduct immunohistochemistry test with anti interleukin-6. Results: Interleukin-6 expression test result% with the average value of group I, II, III, IV and V respectively, 6.56 ± 3.50%; 47.21 ± 9.48%; 20.83 ± 10.40%; 49.39 ± 9.87% and 58.37 ± 17.32%.Conclusion: The administration of co-chemotherapy ethyl acetate fraction of longjack roots (Eurycoma longifolia Jack) and doxorubicin is effective inlowering aromatase expression, however not effective in reducing IL-6 expression compared to single regiment doxorubicin in DMBA-induced rat models.
Uji Aktivitas Ekstrak Daun Secang (Caesalpinia sappan L) terhadap Pertumbuhan Bakteri Escherichia coli Aba, Nurulvalia M; Hidayat, Muh; Yusuf, Siti Salma
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 2 (2021): August, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i2.239

Abstract

Tanaman Secang (Caesalpinia Sappan L) merupakan tanaman tradisional berasal dari Suku Caesalpiniaceae yang dipercaya oleh masyarakat dapat mengobati batuk berdarah, diare, darah kotor, penawar racun, dan gangguan sirkulasi darah. Penyelidikan fitokimia mengungkapkan bahwa ekstrak daun secang terdapat kandungan senyawa kimia di dalamnya terdapat senyawa saponin dan flavonoid. Penelitian dilakukan untuk memahami kemampuan antibakteri dari ekstrak daun secang Caesalpinia sappan L dalam menghambat perkembangan Eschericia coli. Metode uji aktivitas antibakteri yang digunakan adalah Penelitian ini dilakukan dengan menggunakan metode difusi agar. Metode ekstraksi dilakukan yaitu maserasi dengan pelarut etanol 70%. Hasil menunjukan bahwa daun secang memiliki sifat antibakteri terhadap Eschericia coli dengan zona hambat pada variasi konsentrasi ekstrak yang digunakan yaitu 20%,40% dan 80% berturut-turut adalah 34,53 mm, 29,83 mm, dan 32,63 mm. Kesimpulan, ekstrak etanol daun secang mempunyai daya hambat sangat kuat pada konsentrasi 20% yaitu 34,53 mm terhadap pertumbuhan Eschericia coli.Secang plant (Caesalpinia Sappan L) is a traditional plant that comes from the Caesalpiniaceae tribe which is believed to treat coughing up blood, diarrhea, dirty blood, antidote, and blood circulation disorders. Phytochemical investigations revealed that Secang leaf extract contains chemical compounds in it contains saponins and flavonoids. The research was conducted to understand the antibacterial ability of secang leaf extract  inhibiting the development of Eschericia coli. Test method The antibacterial activity used in this research was conducted using the agar diffusion method. Extraction method performed namely maceration with 70% ethanol solvent. The results show that the leaves Secang has antibacterial properties against Eschericia coli with zone Inhibition on the variation of the concentration of the extract used is 20%, 40% and 80% respectively are 34.53 mm; 29.83 mm; and 32.63 mm. In conclusion, the ethanol extract of secang leaves has a very high inhibitory power strong at a concentration of 20% is 34.53 mm on growth Escherichia coli.
Co-Authors Aba, Nurulvalia M Hidayat, Muh Laela Hayu Nurani Sitarina Widyarini