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Ekstraksi kombinasi ultrasonik dan enzimatis untuk senyawa asam klorogenat dari Cascara Kopi Arabika Kerinci Lestari , Siti Marwah; Rahmaha, Vindi Annisa; Khairunnisa , Selda Vira; Salsabilla , Tiskha; Fadillah , Nur
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1220

Abstract

Arabica Coffee Cascara (CKA) has high potential as a source of bioactive compounds such as chlorogenic acid, which has antioxidant activity. The release of active compound can be optimized by combining ultrasonic and enzymatic methods, which are more efficient and environmentally friendly. The aim of this study was to examine the effectiveness of ultrasound-enzymatic-assisted extraction (UEAE) using water as a solvent for chlorogenic acid compound from CKA using Response Surface Methodology Box-Behnken Design (RSM_BBD). Three extraction parameters, such as sonication temperature (35-45°C), enzyme concentration (10-20 mg/g), and enzymolysis temperature (40-60°C), were designed to obtain optimal chlorogenic acid content. Based on the general trend data, results indicated that the highest chlorogenic acid content was 42.55 mg/g of dry extract, and was achieved under specific conditions: a sonication temperature of 40°C, an enzyme concentration of 10 mg/g, and an enzymolysis temperature of 60°C. Verification tests showed a value of 44.17 mg/g dry extract within the model’s prediction range with a 95% confidence level. The current quadratic RSM model with the existing factor design is not yet a reliable predictive tool and only serves to explore the range of operational extraction conditions.
HUBUNGAN PENGETAHUAN TERHADAP TINDAKAN TIDAK AMAN PADA PEKERJA WORKSHOP DI PT BUKAKA TEKNIK UTAMA BALIKPAPAN Fuadi, Yan; Swandito, Adji; Rusba , Komeyni; Fadillah , Nur
IDENTIFIKASI Vol 8 No 2 (2022): IDENTIFIKASI
Publisher : Program Studi Kesehatan dan Keselamatan Kerja

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36277/identifikasi.v8i2.242

Abstract

Bukaka Teknik Utama Balikpapan was founded on November 21, 2000 with a temporary office on Jl. Milono Gunung Sari Village - Central Balikpapan is a business unit of PT. Bukaka Teknik Utama which is engaged in Engineering, Fabrication, Construction Offshore & Onshore and Maintenance Services. In 2005 PT. Bukaka Teknik Utama Balikpapan Branch established an office & workshop on Jl Mulawarman KM 21 Manggar - East Balikpapan. This company has a workforce of 711 people. So many potential hazards that can occur during remanufacturing work. Based on the PPS finding data that has been carried out in the last 3 months, the washing engine area is in first place with the most findings, namely five unsafe behaviors. The five unsafe behaviors include positioning and body movement, risk of un-ergonomic positions, not using PPE, holding objects and reaching and grabbing objects. Of the 55 samples of the knowledge level of PT Bukaka Teknik Utama Workshop workers in the high category, there were 49 workers (89.1%). And the results of research on workers' knowledge of unsafe behavior have a strong relationship. In the unsafe actions of workers, the most dominant category was the safe category, namely 51 respondents (93%).