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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences HISTORIA: Jurnal Program Studi Pendidikan Sejarah
Wisnubroto, Wisnubroto
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Agriculture, Biological Sciences & Forestry Humanities Environmental Science Social Sciences Other

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Mutation Analysis and Single Nucleotide Polymorphism of TP53 Gene in Breast Cancer in East Java Radhiyah, Rizqa; Ardana, I Kade Karisma Gita; Wisnubroto, Wisnubroto; Listyorini, Dwi; Susanto, Hendra
Journal of Tropical Life Science Vol 11, No 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.12

Abstract

The Incidence of Indonesia breast cancer case in 2018 was reported at 20.7% or 160,653 in number. The factors that caused breast cancer is TP53 gene mutation and Single Nucleotide Polymorphism (SNP). This study aimed to determine the mutation and Single Nucleotide Polymorphism (SNP) of TP53 gene in breast cancer. Samples of this study were 9 people chosen based on a purposive technique. The methods include total DNA isolation, DNA quantification, PCR, and sequencing. The results of the sequencing were then analyzed using alignment and blast. The SNP is browsed by the SNP finder on NCBI both followed by protein modeling. The results of this study indicate the existence of mutation in the exon and intron regions. Substitution of Guanine (G) to base Adenine (A) is occur in codon 496 which is a coding region. SNP was also obtained in exon of sample 12. The conclusion of this study is breast cancer can be caused by mutations that occur in the exon and altered the structur of protein structure, so then affect the binding affinity between p53 and its target domain. Tp53 gene mutation is not the only cause of breast cancer staging development, there are other genes that also contribute to the development of cancer stage. In addition, Single Nucleotide Polymorphism in the TP53 gene can be used as a predisposition marker of breast cancer that has potential to be inherited
History Subject Teaching and Learning Strategies of the 2013th Curriculum in SMA Negeri 48 Jakarta Pangestu, Ghalih Purwo; Wisnubroto, Wisnubroto; Husmiati, Ratu
HISTORIA: Jurnal Program Studi Pendidikan Sejarah Vol 14, No 1 (2026): HISTORIA: Jurnal Program Studi Pendidikan Sejarah (Issu in Progress)
Publisher : UNIVERSITAS MUHAMMADIYAH METRO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24127/hj.v14i1.11436

Abstract

This research aims to determine history learning strategies at SMA Negeri 48 Jakarta. This research used qualitative methods. Data collection techniques in this research were observation, interviews and documentation. The data sources used in this research consisted of core informants that include the history subject teacher and class X IPS 1 students, totaling 36 students. The results of this research show that teachers use different learning strategies. History subject teachers are more synonymous with providing historical understanding through discussions, assignments, mind mapping, emphasizing students' individual ability to speak in public, and a responsible attitude, as well as historical understanding through lectures, questions and answers, group assignments using power point media and emphasizing abilities. individual or group to be able to speak in public and a sense of responsibility.
Co-Authors Ardana, I Kade Karisma Gita Dwi Listyorini Hendra Susanto Husmiati, Ratu Pangestu, Ghalih Purwo Radhiyah, Rizqa