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All Journal Jurnal Media Gizi Indonesia (MGI) Jurnal Sosial dan Sains Folia Medica Indonesiana
Oktavian, Puguh
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Astronomy Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Physics

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Clinical and Radiological Study of Patients With Skull Base Fracture After Head Injury Oktavian, Puguh; Romdhoni, Achmad Chusnu; Dewanti, Linda; Fauzi, Asra Al
Folia Medica Indonesiana Vol. 57, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Traumatic brain injury (TBI) is the largest contributor to morbidity and mortality in various parts of the world. Skull base fracture (SBF) is one of the many manifestations that can occur in cases of mild to severe TBI. With varying patterns of TBI, it was necessary to review the characteristics of SBF, clinical manifestations, cerebrospinal fluid leakage, and complications. The data were taken from the medical records of SBF patients who were treated at RSUD (Regional Public Hospital) Dr. Soetomo in the period January 2014 - July 2019. Then, the data obtained were written on the collection sheet and analyzed descriptively using RKward. It was found that SBF most often occurs due to severe TBI (60.14%). 77.7% of SBF patients were male and 35.1% of all patients aged 15-24 years. The most frequent cause was traffic accidents (86.5%). The anterior cranial fossa (ACF) was the most frequently fractured part of the skull base (30.4%). There was a significant relationship between the severity of TBI with the occurrence of CSF leakage and complications. About 33 patients (22.3%) had complications such as pneumocephalus and 9 patients (6.1%) had meningitis. Complications in the form of brain abscess and hydrocephalus in 1 (0.7%) patient each. SBF often occurred in men of productive age 15-24 years. The ACF was the most frequently fractured part. The majority were caused by traffic accidents accompanied by severe brain injuries. The most common complications were pneumocephalus, meningitis, brain abscess, and hydrocephalus.
Neoadjuvant Toripalimab for Renal Cell Carcinoma: A Systematic Review Rananda, Arif; Haikal, Vikri; Oktavian, Puguh; Setyobudi, David; Kristanto, Roy Dwi Antariksa
Jurnal sosial dan sains Vol. 5 No. 11 (2025): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v5i11.32548

Abstract

Toripalimab, a programmed cell death protein-1 (PD-1) inhibitor, has emerged as a promising immunotherapy for renal cell carcinoma (RCC). This systematic review consolidates current evidence on the efficacy and safety of toripalimab-based regimens in RCC management. A systematic review was conducted following PRISMA guidelines and a pre-registered protocol (PROSPERO: CRD42021274404). Multiple databases and trial registries were searched from February 23, 2025. Six studies, including randomized controlled trials (RCTs), case-control studies, and case reports, were included for qualitative synthesis. The analysis demonstrated that toripalimab, particularly in combination with axitinib, significantly improved clinical outcomes compared to standard therapies like sunitinib. One major RCT reported a significant improvement in progression-free survival (PFS) (median 18.0 vs. 9.8 months) and a higher objective response rate (ORR) (56.7% vs. 30.8%). The combination also reduced the risk of disease progression or death by 35% (HR 0.65; 95% CI 0.49–0.86) and showed a significant overall survival (OS) benefit (HR 0.61; 95% CI 0.40–0.92). Favorable responses were also observed in challenging subgroups, including elderly patients and those with sarcomatoid RCC. Adverse events were consistent with known profiles of PD-1 and VEGFR inhibitors, including hypertension, hepatic enzyme elevation, and fatigue, and were generally manageable. Toripalimab-based regimens, especially in combination with axitinib, demonstrate significant improvements in PFS, ORR, and OS for patients with RCC, with a manageable safety profile. These findings support its potential as a valuable therapeutic option. However, further large-scale, multi-center studies with longer follow-up are warranted to confirm these findings.
RUTF: Could This Alternative Therapy be The Answer For Severely Malnourished Children In LMICs? a Critical Meta-Analysis Razan, Rafi Alfian; Widjaja, Nur Aisiyah; Shabrina, Farah Aisha; Ananda, Naoval Diza; Oktavian, Puguh
Media Gizi Indonesia Vol. 21 No. 2 (2026): MEDIA GIZI INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgi.v21i2.142-153

Abstract

Introduction: Childhood malnutrition in the under-5 age group represents a critical challenge to global health systems. Current WHO treatment protocols recommend standardized formula diet (F-100) following the stabilization period to facilitate catch-up growth. In recent years, Ready-to-Use Therapeutic Food (RUTF) has gained widespread adoption across low- and middle-income countries (LMIC) owing to its accessibility for community-level interventions. The established benchmark for appropriate weight gain in children between 6-60 months ranges from 5-10 g/kg/day. Objectives: The present investigation sought to evaluate the comparative effectiveness of RUTF versus F-100 in promoting weight gain among malnourished children. Methods: This investigation adhered to the 2020 PRISMA guidelines for systematic reviews and meta-analyses. Statistical analyses employed standard meta-analytic procedures with random effects modeling based on the classical DerSimonian–Laird approach, implemented in R version 4.4.1. Data from eight investigations involving 2084 participants were synthesized to evaluate the principal outcome of bodyweight increase. Results: Children receiving RUTF demonstrated significantly superior weight gain relative to those receiving F-100. RUTF administration resulted in an additional 2.96 g/kg/day weight gain compared to F-100 ([95% CI 1.82 to 4.16], p-value <0.001). Children managed with RUTF exhibited elevated rates of weight gain compared to F-100 recipients. Despite both interventions promoting weight increase, neither achieved the velocity necessary for adequate catch-up growth in LMIC children presenting with severe acute malnutrition (SAM). Conclusions: These findings emphasize the necessity for novel supplementation approaches to achieve optimal catch-up growth in children with SAM.
Co-Authors Ananda, Naoval Diza Fauzi, Asra Al Haikal, Vikri Kristanto, Roy Dwi Antariksa Linda Dewanti Nur Aisiyah Widjaja, Nur Aisiyah Rananda, Arif Razan, Rafi Alfian Romdhoni, Achmad Chusnu Setyobudi, David Shabrina, Farah Aisha