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Dilla, Tasya Nurlaila
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Health Professions Medicine & Pharmacology Nursing Public Health

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In vivo study of the antihypertensive effect of bidara leaf (Ziziphus spina-christi) during pregnancy Dilla, Tasya Nurlaila; Hadisaputro, Suharyo; Santjaka, Aris
MEDISAINS Vol 19, No 2 (2021)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v19i2.11431

Abstract

Background: Bidara is drought tolerant and very easy to grow in tropical climates such as Indonesia. Bidara contains a combination of calcium, potassium, and magnesium, and active flavonoid compounds, and antioxidant activity that play a role in inhibiting free radical damage, improving endothelial function so that it can potentially lower blood pressure. Previous studies explained that a dose variant of no more than 300mg/kg BW is beneficial while minimizing pathological changes. However, there has been no research related to the effect of bidara leaf in lowering blood pressure, so it is necessary to do related research.Objective: Analyze the effect of bidara leaf extract at a 200 mg/kg BW dose and 300 mg/kg BW on systolic and diastolic blood pressure.Methods: 24 pregnant female Wistar rats induced hypertension, aged 6-8 weeks with a weight of 130-230 grams. The rats were randomized so that they consisted of 2 control groups and two experimental groups, which were given various doses of bidara leaf for nine days. Blood pressure was measured using non-invasive CODA.Results: The blood pressure of rats in the bidara leaf extract group at doses of 200mg/kg BW and 300mg/kg BW decreased systolic and diastolic compared to the control group (p<0.05). The 200mg/kg BW dose group experienced a decrease in blood pressure of 12.3% for systolic and 16.32% for diastolic; the 300mg/kg BW dose group experienced a decrease in blood pressure of 19.99% for systolic and 27.73% for diastolic.Conclusion: Bidara leaf extract can reduce the blood pressure of pregnant rats with hypertension.
NON-BLOOD ANEMIA DETECTION: A SYSTEMATIC REVIEW Dilla, Tasya Nurlaila; Widyawati, Melyana Nurul; Dhanio, Yeyen Wulandari; Pricilia, Desiska; Nggusual, Rili Ronia; Syahria, Nur; Masruroh, Maya Latifatul
Journal of Applied Health Management and Technology Vol. 3 No. 3 (2021): July 2021
Publisher : Postgraduate Program , Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jahmt.v1i3.7478

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Background: Anemia is a serious global health problem that may result in hemorrhage, premature birth, Low Birth Weight, and fetal development disorder. To this day, detection for anemia in midwifery care is still invasive, despite the fact that it has some drawbacks, including the need for blood sampling, expensive cost, the need for skillful health care personnel, and the need for laboratory facility. All these drawbacks make people less interested in undergoing examination. The WHO recommends hemoglobin (Hb) screening using non-invasive methods. Method: This systematic review is based on the PRISMA protocol with searches from the database of Google Scholar, Pubmed, and Science Direct for publications published from 2010 to 2019. The keywords used were: “Early Detection for Anemia”, “Screening for Anemia”, and “Non-Invasive Anemia Detection” with inclusion criteria of publications written in English and Bahasa Indonesia, and those published between 2011 and 2019, which resulted in 16 selected publications.Results: Searches for publications landed 302 published publications, 16 of which meet the criteria. These 16 selected publications consist of 10 publications detecting anemia using fingers, and the remaining six, detect anemia using conjunctiva.  Conclusion: Non-invasive methods are deemed effective in detecting anemia because they are easy to implement, do not require blood sampling, affordable, and do not need skillful health care personnel to administer them, as well as having less possibility for infection. These advantages make non-invasive methods applicable in midwifery care.
Co-Authors Aris Santjaka Dhanio, Yeyen Wulandari Masruroh, Maya Latifatul Melyana Nurul Widyawati Nggusual, Rili Ronia Pricilia, Desiska Suharyo Hadisaputro Syahria, Nur