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Syarif Bakri
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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The Effectiveness Between Tamsulosin and Solifenacin Combined with Tamsulosin on Treatment of Ureteral Stent-Related Symptoms Berry Erida Hasbi; Muhammad Asykar Palinrungi; Khoirul Kholis; Syarif Bakri; Syakri Syahrir; Firdaus Kasim
Nusantara Medical Science Journal Volume 6 Issue 1, January - June 2021
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v6i1.14263

Abstract

Introduction: The clinical usage of the ureteral stent caused several stent-related symptoms (SRSs), including lower urinary tract symptoms, pain, general health, work performance, sexual matter and additional problems. This study aims to evaluate the effectiveness between tamsulosin and solifenacin combined with tamsulosin for SRSs.Methods: This double blind randomized controlled trial used 50 patients. Between September 2020 and February 2021, patients underwent double-J stenting after retrograde ureteroscopy were analyzed. All patients would be randomized in a 1:1 ratio in a 1:1 ratio to receive either tamsulosin 0,4 mg (Group A: 25 participants) or tamsulosin 0,4 mg & solifenacin 5 mg combination (group B: 25 participants).We used the Ureteral Symptoms Score Questionnaire (USSQ) as an outcome measure at 1s, 2nd, 3rd and 4th weeks after stent insertion. Results: Group A was found more in women, while in group B was more in men. The highest age in group A and group B was 50-60 years old (36% and 64%). The location of stenting in group A was found more in left (60%), while the group B in the right (52%). Both groups had more patients who were normal nutritional status (60%). There was an improvement in pain and work performance after treatment in both groups, meanwhile group B showed better improvement than group A at all weeks. in addition, there was an improvement in urinary symptoms and sexual matter in group B better than in group A at 2nd to 4th week. Furthermore, group B showed better improvement in general health and additional problem only at 4th week. Conclusions: Combination therapy with tamsulosin and solifenacin improved USSQ score more than the monotherapy group. This implied that combination therapy is optimal for improving SRSs.
Luaran Klinis Orkhidektomi Bilateral pada Kanker Prostat Metastasis: Pengalaman Indonesia Syarif Bakri; Rainy Umbas; Chaidir Arif Mochtar
Indonesian Journal of Cancer Vol 5, No 4 (2011): Oct - Dec 2011
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (202.65 KB) | DOI: 10.33371/ijoc.v5i4.202

Abstract

Kanker prostat merupakan kanker yang lebih banyak ditemukan di negara Barat dibandingkan Asia. Berbagai faktor prognostik telah diteliti untuk memprediksi angka kesintasan pasien yang diterapi hormonal. Pada penelitian ini dievaluasi peranan usia, PSA, jumlah lesi metastasis, skor Karnofsky, hemoglobin, dan kreatinin sebagai faktor prognostik untuk menilai angka kesintasan pada kanker prostat metastasis di Indonesia yang dilakukan kastrasi dengan orkhidektomi. Penelitian dilakukan secara retrospektif dengan mengumpulkan data rekam medik penderita kanker prostat dengan metastasis yang dilakukan orkhidektomi subkapsular dan belum mengalamihormone resistance prostate cancer(HRPC) di Klinik Khusus Urologi RSCM dan RS Kanker Dharmais Jakarta, periode Januari 1995- Desember 2008 denganfollow-up24 bulan. Selama periode penelitian, terdapat 194 pasien yang memenuhi kriteria dan 99 pasien di antaranya memiliki data lengkap untuk dianalisis. Dari analisis multivariat didapat kekuatan hubungan dari yang terbesar sampai yang terkecil, yaitu jumlah lesi (HR=8,56), kreatinin (HR=3,24), hemoglobin (HR=0,94), dan skor Karnofsky (HR=0,28). Disimpulkan bahwa jumlah lesi dan kreatinin secara statistik signifikan mempengaruhi kesintasan.Kata kunci: jumlah lesi, kanker prostat, kesintasan, kreatinin, metastasis
Co-Authors Berry Erida Hasbi Chaidir Arif Mochtar Firdaus Kasim Khoirul Kholis Muhammad Asykar Palinrungi Rainy Umbas Syakri Syahrir