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All Journal Althea Medical Journal The Indonesian Biomedical Journal Sari Pediatri Jurnal Psikiatri Surabaya (Surabaya Psychiatry Journal) AgriHealth: Journal of Agri-food, Nutrition and Public Health JOURNAL LA MEDIHEALTICO AKSONA Asian Journal of Health Research Prominentia Medical Journal Jurnal Widya Medika
Pramita Anindya Nugraheni
Department Of Pediatrics, Faculty Of Medicine, Hang Tuah University; Dr. Ramelan Naval Hospital, Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Risk Factors for Febrile Seizures in Children Aged 6 – 59 Months in Surabaya, East Java Febrianto Adi Husodo; Sitti Radhiah; Pramita Anindya Nugraheni
Althea Medical Journal Vol 8, No 3 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v8n3.2351

Abstract

Background: Febrile seizures are common in children under 5 years of age. Parents are concerned when their children have seizures; therefore, it is necessary to provide promotive and preventive education regarding the risk factors for febrile seizures so that parents are more prepared. This study aimed to explore the risk factors for febrile seizures in children.Methods: This case-control study was conducted on 170 children. Sampling was carried out by purposive sampling on inpatients and/or outpatients at the Pediatric Department Dr. Ramelan Naval Hospital Surabaya during May 2019-July 2020. Secondary data for children with fever were retrieved from medical records, with seizures (n85) and without seizures (n85) as a control group. Furthermore, data on temperature, age, birth weight, and history of asphyxia were analyzed and compared, using the chi-square test or Fisher’s exact test.Results: There was a significant difference between the case and control groups regarding the history of asphyxia and the occurrence of febrile seizures (p=0.002; OR=26.39; and 95% CI 1.52-455.62). There was no significant difference between the risk factors for high temperature (p=0.12), age (p=0.52), or birth weight (p=0.37) with the occurrence of febrile seizures.Conclusions: A history of asphyxia in children under five years is a risk factor for febrile seizures. Appropriate education from health professionals can help parents improve their knowledge, attitudes, and practices in dealing with febrile seizures and their risk factors.
The Effect of Enterobiasis Prevention Education on the Level of Knowledge of Students Putri, Fransisca Dian Nathania; Nugraheni, Pramita Anindya; Risma, Risma
Journal La Medihealtico Vol. 5 No. 1 (2024): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v5i1.1041

Abstract

Enterobiasis is a disease caused by the parasitic worm Enterobius vermicularis. This disease often occurs in children aged 5-14 years. Enterobiasis is a disease that can cause symptoms, one of which is itching in the perianal area. This can cause sleep disorders so that a child's concentration can be disturbed and of course this will affect the child's learning ability, as well as impacting the quality of a generation. This study aims to determine the effect of health education on the level of knowledge of elementary school students in grades 4-6 at SDN Kaliasin 1 Surabaya regarding the prevention of enterobiasis. This research is an observational analytical study with a cross sectional design and uses primary data in the form of a questionnaire. The method used in this research is a quantitative method. The research results showed that before health education, respondents with a good level of knowledge were 24.7%, 48.1% were adequate, and 27.2% were poor, whereas after health education the results obtained were respondents with a good level of knowledge of 64.2%, 24.7% sufficient, and less by 11.1%. Based on the results of the paired Wilcoxon test, the p value was 0.000, which means the p value <0.005, so it can be concluded that there is an influence of health education on the level of knowledge of elementary school students in grades 4-6 at SDN Kaliasin 1 Surabaya on the prevention of enterobiasis.
Diagnostic and Treatment Challenges of Recurrent Tuberculosis in Patient with Drug-Induced Hepatotoxicity: A Case Report Devanda, Kasilda Pasha; Avelline, Kendraadine Dheayu; Lauwis, Keziah Queency; Kharizmatika; Hayati, Khofifah Bela Rachmanu; Adiwinoto, Ronald Pratama; Nugraheni, Pramita Anindya; Rasyida, Annisa Ullya
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.195

Abstract

Introduction: Pulmonary tuberculosis (TB) remains one of the most significant global health challenges, especially complicated by cases with incomplete treatment histories. The recurrence of TB poses diagnostic and therapeutic dilemmas that significantly impact patient outcomes. Case Presentation: We report a case of a 57-year-old female patient presenting with recurrent pulmonary TB after an incomplete treatment course. The patient's history revealed gaps in adherence to the prescribed TB regimen, leading to multiple relapses. In this study, we found that patients undergoing TB treatment may experience liver damage as a result of the TB medication, also known as DIH. Comprehensive diagnostic procedures, including chest radiography, sputum culture, and molecular testing, confirmed recurrent TB. The patient's clinical manifestations, treatment plan, and response to therapy are detailed. Conclusion: Recurrent TB is common, particularly in older adults, and is influenced more by environmental factors than occupation. Additionally, ATT poses risks of hepatotoxicity, especially in malnourished patients, underscoring the importance of managing side effects and addressing factors like malnutrition to prevent complications and improve outcomes. This case underscores the importance of complete adherence to TB treatment regimens and highlights the challenges in managing recurrent TB. It emphasizes the need for robust follow-up, patient education strategies, early diagnosis, and prompt intervention to prevent recurrence and enhance patient outcomes.
Laporan Kasus Serial : Anensefali Herdiyantini, Mita; Nugraheni, Pramita Anindya; Novitania, Milleniawati Putri; Renagupita, Melani Sinastri; Setiabudi, Martin Panglipuringtyas; Hendrawan, Michelle; Widisaputro, Michael Deni
Bahasa Indonesia Vol 5 No 2 (2024): Prominentia Medical Journal
Publisher : Universitas Ciputra Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37715/pmj.v5i2.5053

Abstract

Preface : Anencephaly is one of the most common forms of neural tube defects and is the second most serious congenital abnormality after congenital heart defects. The overall prevalence of Anencephaly in the world is 5.1 per ten thousand births. Case report : The first patient aged 26 years came without complaints when an ultrasound in the second trimester revealed Anencephaly fetal abnormalities and the pregnancy was terminated with vaginal delivery. The second patient aged 28 years came without complaints when an ultrasound in the first trimester revealed Anencephaly fetal abnormalities and a vaginal delivery was carried out. Discussion : Anencephaly is an abnormality in fetal development characterized by the absence of skull bones accompanied by a lack of most or all of the fetal brain tissue. The main risk factors are lack of folic acid consumption which can occur due to drugs that inhibit folate absorption, the body's increased need for folic acid, and lack of food intake. Early detection requires ultrasound, AFP and acetylcholinesterase examination in the second trimester. The recommended prevention is the consumption of folic acid from preparation for pregnancy until the time of pregnancy.
Hyperbaric Oxygen Therapy Increases Brain-Derived Neurotrophic Factor as well as Decreases Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in Autism Spectrum Disorder Verna Biutifasari; Ni Komang Sri Dewi Untari; Pramita Anindya Nugraheni; Ronald Pratama Adiwinoto; Djatiwidodo Edi Pratiknya; Vendra Setiawan; Hartono Kahar; Betty Agustina Tambunan
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3358

Abstract

BACKGROUND: Neuroinflammation and immune dysregulation are frequently viewed as contributing factors of autism spectrum disorder (ASD). Brain-derived neurotrophic factor (BDNF) is involved in the maintenance of neuron viability, as well as in neuron differentiation. Meanwhile, Systemic Immune-Inflammatory Index (SII) and Systemic Inflammatory Response Index (SIRI) are basic hematological indices used to assess inflammation and immune status. Hyperbaric oxygen (HBO) is known to enhance cerebral blood flow and reduce inflammation, however, not many studies have observed the its effect on BDNF level, SII, and SIRI in ASD subjects; therefore, this study was performed.METHODS: Fifteen ASD subjects were involved in this study and received HBO therapy 10 times within a 2-week period. The HBO therapy was performed by letting the subjects got into an isolated chamber filled with 100% oxygen and 1.3 ATA pressure for 60 minutes. Pre- and post-therapy blood samples were taken from subjects. BDNF level was measured with Enzyme Linked Immunosorbent Assay (ELISA), while neutrophils, monocytes, lymphocytes and platelets were measured by hematology analyzer for the calculation of SII and SIRI.RESULTS: Post-therapy BDNF level was higher than pre-therapy (1.84 ng/mL vs. 1.46 ng/mL; p=0.039). The increased in BDNF suggested reduced neuroinflammation and enhanced connections between neurons. Both post-therapy SII (672.4 vs. 359.4; p=0.005) and SIRI (1.3 vs. 0.7; p=0.009) were significantly lower than pre-therapy indexes. Decreased in SII and SIRI signified a reduction in neuroinflammation.CONCLUSION: HBO therapy increases BDNF level, also decreases SII and SIRI in ASD subjects. These results suggest that HBO has an effect on neuroinflammation, specifically in ameliorating inflammation.KEYWORDS: autism spectrum disorder, BDNF, SII, SIRI, hyperbaric oxygen therapy
Sleeping Patterns, Personality Insights, and Emotional Savvy: A Study of Medical Students at Hang Tuah University in Surabaya A. S. Ramadhina, Nurul Saqinah; Anindya Nugraheni, Pramita; Irawati, Ade; Pratama A., Ronald
Jurnal Psikiatri Surabaya Vol. 14 No. 2 (2025): November
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jps.v14i2.68541

Abstract

Introduction: Adequate sleep is crucial for adolescent health because sleep deprivation can induce moodiness and frustration. Personality, encompassing introversion and extraversion, influences behavior and interaction patterns. Emotional intelligence pertains to the recognition and management of one’s own emotions and those of others. Methods: This study explored the relationships among sleep quality, personality type, and emotional intelligence among 5th and 7th semester students at the Faculty of Medicine, Hang Tuah University Surabaya, from 2024--2025. Using a descriptive analytic design and cross-sectional approach, 196 respondents were selected via purposive sampling. Data were collected via the Pittsburgh Sleep Quality Index, Personality Type Questionnaire, and Emotional Intelligence Questionnaire, which are distributed online. No personally identifiable information was collected, ensuring the full anonymity of the respondents. Results: Spearman’s correlation analysis revealed significant relationships between sleep quality and personality type (r = 0.235, p = 0.0005), between sleep quality and emotional intelligence (r = 0.212, p = 0.0005), and between personality type and emotional intelligence (r = 0.1476, p = 0.0005). Poor sleep quality was associated with lower emotional intelligence, indicating that sleep affects emotional awareness. Similarly, personality type was correlated with variations in emotional intelligence. Conclusion: This study revealed significant correlations between sleep quality, personality type, and emotional intelligence among medical students, suggesting that these factors play a key role in their emotional wellness.
Pengaruh Terapi Oksigen Hiperbarik terhadap Anak dengan Gangguan Spektrum Autisme Nugraheni, Pramita Anindya; Untari, Ni Komang Sri Dewi; Agustin, Renny; Oktavia, Reza Mardiana Ayu; Rantika, Rheina Hasna; Hadi, Rifqi Athaya Vinanta; Utami, Rina Mega
Sari Pediatri Vol 25, No 5 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp25.5.2024.316-21

Abstract

Latar belakang. Gangguan Spektrum Autisme merupakan kelainan perkembangan saraf dengan ciri-ciri gangguan komunikasi sosial, interaksi sosial yang terbatas, dan pola perilaku yang berulang, sesuai dengan klasifikasi DSM V. Terapi yang umum digunakan adalah Applied Behaviour Analysis, tetapi Terapi Oksigen Hiperbarik menjadi fokus studi terkini yang melibatkan pemberian oksigen 100% pada tekanan atmosfer yang lebih tinggi, menjadi opsi non-invasif yang dapat menyediakan oksigen optimal untuk organ tubuh.Tujuan. Penelitian ini bertujuan mengevaluasi pengaruh TOHB pada anak ASD melalui Childhood Autism Rating Scale.Metode. Studi analitik dilakukan dengan desain pra-eksperimental one group pretest-posttest, melibatkan 15 pasien ASD dari Lakesla Drs. Med. R. Rijadi S.,Phys. Data dikumpulkan dari Januari hingga Agustus 2023.Hasil. Analisis data pre-test dan post-test menunjukkan signifikansi (p=0.001). Evaluasi aspek hubungan dengan orang lain (p=0.004), imitasi (p=0.011), respon emosional (p=0.001), penggunaan objek (p=0.008), adaptasi (p=0.007), respon mendengar (p=0.014), rasa, bau, sentuh (p=0.034), ketakutan atau gugup (p=0.009), komunikasi verbal (p=0.059 dan p=0.157), tingkat aktivitas (p=0.004), level dan konsistensi respon intelektual (p=0.025), serta kesan umum (p=0.025).Kesimpulan. Pemberian TOHB pada anak ASD dapat meningkatkan berbagai aspek fungsi sosial dan menurunkan tingkat aktivitas, rasa takut, serta gugup. Penelitian ini memberikan dasar untuk lebih memahami peran TOHB dalam manajemen ASD.
A Rare Pediatric Case of Dengue Hemorrhagic Fever with Encephalopathy and Suspected Subdural Hemorrhage Aulia Cempakasari; Tiara Rahmawati; Alief Qobidh Al Bashor Arifin; Dewi Syahputri; Firdha Yekti Hutami; Renata Prameswari; Pramita Anindya Nugraheni; Ronald Pratama Adiwinoto; I Made Dwi Mertha Adnyana
Asian Journal of Health Research Vol. 4 No. 3 (2025): Volume 4 No 3 (December) 2025
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v4i3.262

Abstract

Introduction: Dengue Hemorrhagic Fever (DHF) is a severe arboviral infection that rarely leads to neurological complications. Dengue encephalopathy, often secondary to metabolic disturbances or shock, presents a significant diagnostic and management challenge in the pediatric population. Case Presentation: We report the case of a 4-year-3-month-old obese girl presenting with fever, gastrointestinal symptoms, and progressively decreasing consciousness (apathetic). Diagnosis of DHF was confirmed by a positive NS1 antigen test, severe thrombocytopenia (nadir 14,000/µL), and hemoconcentration with pleural effusion. Hepatic involvement was noted (SGOT 117.81 U/L). Neurological involvement was characterized by clinical encephalopathy, and a head CT scan revealed hyperdense lesions suspecting subdural hemorrhage (SDH). The patient required multidisciplinary management in the Intensive Care Unit (ICU) for supportive fluid therapy, inotropic support (Dobutamine), and platelet transfusion. The patient showed marked clinical improvement and was discharged on day nine. At a two-week post-discharge follow-up, she demonstrated full cognitive and motor recovery with no neurological sequelae Conclusion: This case highlights the critical need for clinical vigilance for rare, simultaneous neurological complications (encephalopathy and suspected SDH) in pediatric DHF. It underscores that early diagnosis and aggressive, multidisciplinary supportive care can lead to complete recovery even in severe presentations.
Clinical Improvement in Autism Spectrum Disorder Symptoms Following Hyperbaric Oxygen as Adjuvant Therapy in a 12-Year-Old Boy Ni Komang Sri Dewi Untari; Pramita Anindya Nugraheni; Renny Agustin; Reza Mardiana Ayu Oktavia; Rheina Hasna Rantika; Rifqi Athaya Vinanta Hadi; Rina Mega Utami; Ronald Pratama Adiwinoto
AKSONA Vol. 6 No. 1 (2026): JANUARY 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v6i1.70643

Abstract

Highlight: The potential role of hyperbaric oxygen therapy (HBO) as an adjunctive treatment for autism spectrum disorder (ASD), demonstrating significant improvements in clinical symptoms. By exploring the plausible mechanisms of HBO, the manuscript underscores the importance of further research and clinical trials to validate its efficacy and safety in the ASD population. This study adds to the literature advocating for innovative therapeutic strategies that address the complex interplay of oxidative stress, neuroinflammation, and mitochondrial dysfunction, inviting a personalized treatment approach.   ABSTRACT Introduction:  Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental condition influenced by both genetic predispositions and environmental factors. Its underlying pathophysiology commonly involves oxidative stress, impaired cerebral perfusion, neuroinflammation, immune dysregulation, and mitochondrial dysfunction. Although conventional interventions, such as applied behavior analysis (ABA), are commonly employed, they may yield limited progress for some individuals. Consequently, emerging interventions, such as hyperbaric oxygen therapy (HBO), show promise for enhancing neurological outcomes and warrant further exploration. HBO, a well-established treatment for decompression sickness, is currently being investigated for its potential benefits in various neurological disorders, including ASD. Case: We present a case of ASD in a 12-year-old boy characterized by minimal eye contact, limited expressive language, and restricted, repetitive behaviors. On neurological examination, the patient was alert and capable of spontaneous eye opening, vocalizing incomprehensible words, and, at times, responding to simple commands. Despite undergoing ABA therapy, the patient exhibited limited developmental progress. The patient was subsequently undergoing hyperbaric oxygen therapy (HBO) at 1.3 ATA for 60 minutes for 10 days. Following the completion of HBO therapy, there was a decline in the CARS score from 41.5 (severe) to 29 (mild), the ATEC score from 115 to 68, the platelet count (51,000 / μL), and interleukin-1β levels (181.4 pg/mL). Conclusion: This case highlights the potential of HBO therapy as an adjunctive treatment modality for ASD, offering significant symptomatic improvements in a patient for whom traditional therapies were insufficient. The presumed mechanisms underlying these effects include anti-inflammatory effects and enhanced cerebral oxygen delivery, which may facilitate neuronal recovery and function. Given these findings, further research and clinical trials are warranted to confirm the therapeutic efficacy, long-term benefits, and safety profile of HBO therapy.
The Relationship Between Feeding Patterns and Maternal Knowledge about Nutrition with the Incidence of Stunting in Children Age 0-5 Years in the Working Area of the Gedongan Health Center, Mojokerto City Nadya Aisyah Sasqia Putri; Ronald Pratama Adiwinoto; Prima Arundani; Pramita Anindya Nugraheni; I Made Dwi Mertha Adnyana
AgriHealth: Journal of Agri-food, Nutrition and Public Health Vol 5, No 1 (2024): April
Publisher : Research and Development Center for Food, Nutrition and Public Health (P4GKM) LPPM UNS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/agrihealth.v5i1.83808

Abstract

Stunting is a prolonged state of chronic malnutrition. This disorder is characterized by having a body length-for-age or body height-for-age measurement that falls below the -2 standard deviation established by the World Health Organization (WHO). The etiology of stunting is multifaceted, encompassing factors such as nutrition, feeding practices, infectious illnesses, and household income. Maternal understanding of nutrition, including dietary factors, is also associated with the occurrence of stunting. This study aimed to establish the relationship between feeding habits and maternal knowledge of nutrition with the prevalence of stunting in the operational region of the Gedongan Health Center, located in Mojokerto City. This study is an observational analytical study employing a cross-sectional design. The study’s population consisted of all women with children residing in the working area of the Gedongan Health Center. This study encompassed 144 participants who completed the Child Feeding Questionnaire (CFQ) regarding eating practices and a questionnaire assessing maternal knowledge of nutrition. The objective was to examine the relationship between these factors to height and age. The chi-square test results indicate a statistically significant association between feeding practices and stunting (p = 0.0001) and maternal knowledge about nutrition and stunting (p = 0.0001). The survey revealed that most children had been provided with appropriate feeding patterns, and most moms had a commendable nutritional understanding. The study’s findings indicate a noteworthy relationship between feeding behaviors and mothers’ nutrition knowledge.
Co-Authors A. S. Ramadhina, Nurul Saqinah Aditya Mahardika Wahono Adnyana , I Made Dwi Mertha Agustin, Renny Alief Qobidh Al Bashor Arifin ANNISA ULLYA RASYIDA Aulia Cempakasari Avelline, Kendraadine Dheayu Betty Agustina Tambunan Devanda, Kasilda Pasha Dewi Syahputri Djatiwidodo Edi Pratiknya Febrianto Adi Husodo Firdha Yekti Hutami Hadi, Rifqi Athaya Vinanta Hartono Kahar, Hartono Hayati, Khofifah Bela Rachmanu Hendrawan, Michelle Herdy Primanda Ikhwani Alamsyah Irawati, Ade Kharizmatika Lauwis, Keziah Queency Michael Alexander Miranda, Stefani Mita Herdiyantini Moh Fathi Ilmawan Nadya Aisyah Sasqia Putri Nadya Shita Herwindha Ni Komang Sri Dewi Untari Ni Komang Sri Dewi Untari Novitania, Milleniawati Putri Oktavia, Reza Mardiana Ayu Pratama A., Ronald Prima Arundani Putri, Fransisca Dian Nathania Rantika, Rheina Hasna Renagupita, Melani Sinastri Renata Prameswari Renny Agustin Reza Mardiana Ayu Oktavia Rheina Hasna Rantika Rifqi Athaya Vinanta Hadi Rina Mega Utami Risma Risma, Risma Ronald Pratama Adiwinoto Salsabila Auliahadi Setiabudi, Martin Panglipuringtyas Sitti Radhiah Tiara Rahmawati UNTARI, NI KOMANG SRI DEWI Utami, Rina Mega Vendra Setiawan Verna Biutifasari Widisaputro, Michael Deni