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All Journal Locus: Jurnal Konsep Ilmu Hukum JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Gosal, Ervina
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Education Environmental Science Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Association between ApoA1, ApoB, and the ApoB/ApoA1 ratio with the risk of diabetic neuropathy: A systematic review and meta-analysis Gosal, Ervina; Djuartina, Tena; Sutrisno, Alfred; Budianto, Iskandar R.
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art12

Abstract

Diabetic neuropathy is a common complication of diabetes mellitus and a major contributing factor to the development of diabetic foot ulcers (DFU). Apolipoproteins A1 (ApoA1) and B (ApoB), as well as the ApoB/ApoA1 ratio, play a crucial role in lipid metabolism and are believed to be involved in the development of neuropathic damage in individuals with diabetes. This study highlights the association between ApoA1, ApoB, and the ApoB/ApoA1 ratio with the risk of developing diabetic neuropathy. A systematic review was conducted following the PRISMA guidelines. An extensive literature search was conducted on December 7, 2024, using multiple databases, including PubMed, ProQuest, EBSCOhost, and Medline. There were no language or publication date restrictions. This synthesis relied solely on odds ratios (ORs) with 95% confidence intervals (CIs) as effect sizes. Included studies were observational in design, examining the association between ApoA1, ApoB, or the ApoB/ApoA1 ratio with diabetic neuropathy in an adult population. Of the 320 studies identified, 5 met the criteria for inclusion in the qualitative synthesis and meta-analysis, involving 2,756 diabetic patients. Findings showed higher ApoB levels and lower ApoA1 levels in patients with diabetic neuropathy compared with controls. However, no significant association was found between ApoB, ApoA1, or the ApoB/ApoA1 ratio with diabetic neuropathy or DFU risk. This review found no significant association between ApoB, ApoA1, or the ApoB/ApoA1 ratio with diabetic neuropathy or DFU. Further research is needed to explore their potential role in DM complications.
Efektivitas Mediasi dalam Penyelesaian Sengketa Medis di Indonesia Gosal, Ervina; Sirajuddin, Sirajuddin; Andriyanto, Andriyanto
Locus: Jurnal Konsep Ilmu Hukum Vol 5 No 3 (2025): December 2025
Publisher : LOCUS MEDIA PUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56128/jkih.v5i3.621

Abstract

Penelitian ini menganalisis efektivitas mediasi dalam penyelesaian sengketa medis di Indonesia dari perspektif yuridis normatif. Permasalahan utama terletak pada belum adanya pengaturan khusus mengenai mekanisme mediasi medis, termasuk perlindungan hukum bagi mediator dan tenaga medis. Penelitian ini menggunakan metode yuridis normatif dengan pendekatan perundang-undangan, konseptual, kasus, dan perbandingan, serta dianalisis menggunakan teori sistem hukum Lawrence M. Friedman yang menitikberatkan pada substansi, struktur, dan budaya hukum. Hasil penelitian menunjukkan bahwa mediasi sengketa medis belum efektif secara normatif akibat kelemahan substansi hukum, ketiadaan lembaga mediasi khusus di bidang kesehatan, dan rendahnya budaya penyelesaian sengketa non-litigasi di masyarakat. Penelitian ini merekomendasikan pembentukan regulasi pelaksana khusus serta lembaga mediasi nasional di bidang kesehatan guna meningkatkan kepastian hukum dan kepercayaan publik.
Co-Authors Alfred Sutrisno, Alfred Andriyanto Andriyanto Budianto, Iskandar R. Sirajuddin Sirajuddin Tena Djuartina, Tena