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All Journal The New Ropanasuri Journal of Surgery JKKI : Jurnal Kedokteran dan Kesehatan Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Budianto, Iskandar R.
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Hospital Malnutrition in Pediatric Surgery at dr. Cipto Mangunkusumo General Hospital 2015 and Its Associated Factors Cendrawan, Novi Kurnia; Budianto, Iskandar R.
The New Ropanasuri Journal of Surgery
Publisher : UI Scholars Hub

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Abstract

Introduction. Hospital malnutrition is known to increase the length of stays, mortality, and morbidity, however, the factors associated with the development of hospital malnutrition, especially in pediatric surgery patient population, has not been recognized. Method. This study was done to evaluate the occurrence of hospital malnutrition in pediatric surgery population and to identify the factors associated with hospital malnutrition. Primary data was gathered from pediatric surgery patients hospitalized in the pediatric surgery ward of Dr. Cipto Mangunkusumo General Hospital within July–December 2015. Data on age, diagnosis, nutrition status at admission, whether any procedure was done during a hospital stay, fasting duration, duration of surgery, length of stays and classification of surgical procedure done were collected. Univariate and multivariate analysis was done to identify the association between these variables and hospital malnutrition. Results. Out of 198 patients admitted in the pediatric surgery ward, 50 subjects were enrolled. The occurrence of hospital malnutrition among these subjects was 40%. Among the categorical variables (age, diagnosis, nutrition status at admission, whether any procedure was done during a hospital stay, classification of surgical procedure) only the classification of surgical procedure was found to be significantly associated with hospital malnutrition (p = 0.013). Meanwhile, among the numerical variables (fasting duration, duration of surgery, length of stays) only postoperative length of stays was correlated with hospital malnutrition (p = 0.009). Conclusion. It can be inferred that the burden of surgery is associated with hospital malnutrition, and in turn, hospital–malnutrition is associated with increased postoperative length of stays.
Effectiveness of Red Onion Extract (Allium Cepa) on the Elongation of Papillae and Neutrophil Cell in the Gastroesophageal Junction (GEJ) of Sprague Dawley Strain Rats Gastroesophageal Reflux Disease (GERD) Model Blandina, Maria Bernadetta Nadya; ., Vetinly; Djuartina, Tena; Tenggara, Riki; Budianto, Iskandar R.
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 26, No 1 (2025): VOLUME 26, NUMBER 1, April, 2025
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/261202536-42

Abstract

Background: Gastroesophageal acid reflux disease (GERD) is a disorder caused by the reflux of stomach acid when the lower esophageal sphincter (LES) relaxes with a prevalence of around 1.03 billion worldwide. One of the supporting examinations carried out to diagnose GERD is a histopathological examination. This study aims to determine the effect of red onion extract on the papillae elongation and neutrophil cells of the gastroesophageal junction in Sprague Dawley rats. Methods: This experimental study was conducted on Sprague Dawley rats induced with 1 mL of HCl + 1 mL of ascorbic acid, administered into the gastric cardia of the rats, mixed with 1 mL of sodium thiocyanate (NaSCN) and 1.5 mL of sodium nitrite (NaNO₃) to develop a GERD model. The rats were then divided into ten groups with different treatments, including red onion extract (250, 500, 750 mg/kgBW) and PPI (pantoprazole). Results:  It was stated that there was a significant relationship between the effect of red onions and changes in papillae elongation in rats induced by GERD (P-value 0.05). The neutrophil cells showed no significance on the impact of red onion (p-value 0,05). Nor are the papillae elongation and the neutrophil cell changes dose-dependent.Conclusion: A significant reduction in the histopathological appearance of papillae elongation was seen in the majority of the population. However, no significant results were found for the different doses of shallot extract.Keywords: Gastroesophageal acid reflux disease, allium cepa, papillae elongation, red onion extract, neutrophil cells
Association between ApoA1, ApoB, and the ApoB/ApoA1 ratio with the risk of diabetic neuropathy: A systematic review and meta-analysis Gosal, Ervina; Djuartina, Tena; Sutrisno, Alfred; Budianto, Iskandar R.
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 16, No 2, (2025)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol16.Iss2.art12

Abstract

Diabetic neuropathy is a common complication of diabetes mellitus and a major contributing factor to the development of diabetic foot ulcers (DFU). Apolipoproteins A1 (ApoA1) and B (ApoB), as well as the ApoB/ApoA1 ratio, play a crucial role in lipid metabolism and are believed to be involved in the development of neuropathic damage in individuals with diabetes. This study highlights the association between ApoA1, ApoB, and the ApoB/ApoA1 ratio with the risk of developing diabetic neuropathy. A systematic review was conducted following the PRISMA guidelines. An extensive literature search was conducted on December 7, 2024, using multiple databases, including PubMed, ProQuest, EBSCOhost, and Medline. There were no language or publication date restrictions. This synthesis relied solely on odds ratios (ORs) with 95% confidence intervals (CIs) as effect sizes. Included studies were observational in design, examining the association between ApoA1, ApoB, or the ApoB/ApoA1 ratio with diabetic neuropathy in an adult population. Of the 320 studies identified, 5 met the criteria for inclusion in the qualitative synthesis and meta-analysis, involving 2,756 diabetic patients. Findings showed higher ApoB levels and lower ApoA1 levels in patients with diabetic neuropathy compared with controls. However, no significant association was found between ApoB, ApoA1, or the ApoB/ApoA1 ratio with diabetic neuropathy or DFU risk. This review found no significant association between ApoB, ApoA1, or the ApoB/ApoA1 ratio with diabetic neuropathy or DFU. Further research is needed to explore their potential role in DM complications.
Co-Authors ., Vetinly Alfred Sutrisno, Alfred Blandina, Maria Bernadetta Nadya Cendrawan, Novi Kurnia Gosal, Ervina Riki Tenggara Tena Djuartina, Tena