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All Journal KESANS : International Journal of Health and Science
Angrayany Sapar, Puput
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Chemistry Health Professions Medicine & Pharmacology Physics Public Health

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Preliminary Study On Latent Membrane Protein-1 (LMP-1) And Bcl-2 Associated X (BAX) In Exosomes Of Patients With Nasopharingeal Cancer In NTB Provincial Hospital Angrayany Sapar, Puput; Kadriyan, Hamsu; Yudhanto, Didit
Jurnal KESANS : Kesehatan dan Sains Vol 1 No 2 (2021): KESANS : International Journal of Health and Science
Publisher : Rifa'Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (278.325 KB) | DOI: 10.54543/kesans.v1i2.9

Abstract

Nasopharyngeal cancer is one of the most common types of cancer in Indonesia, especially head and neck cancer. One of the etiology of this cancer is infection with Epstein-Barr virus. Early diagnosis is difficult to establish because the early signs and symptoms of nasopharyngeal carcinoma are not specific. Examination of latent membrane protein-1 (LMP1) oncogene expression and BCL2-associated X (BAX) gene expression proved to be useful in the identification of nasopharyngeal cancer. LMP1 oncogene is an oncogene that functions as a tumor necrosis factor receptor (TNFR), so that apoptosis does not occur and promotes invasion and metastasis. The BAX gene is a pro-apoptotic gene that inhibits cancer development, but its regulation will be downregulated by LMP1 because LMP can protect B-cells from apoptosis.
Co-Authors Didit Yudhanto Kadriyan, Hamsu