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All Journal Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Buletin Kedokteran dan Kesehatan Prima
Nasution, Muhammad Fauzi
Unknown Affiliation
Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences

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Pengaruh Ekstrak Buah Pala (Myrisca Fragnant Houtt) Terhadap Fungsi Dan Gambaran Hispatologi Hati Tikus Penderita Diabetes Melitus Widiarini, Kurnia; Nasution, Muhammad Fauzi; Novita, Cut Elvira
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 2 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i2.762

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak buah pala (Myristica fragrans Houtt.) terhadap fungsi hati dan gambaran histopatologi hati pada tikus putih galur Wistar jantan yang mengalami diabetes melitus. Diabetes melitus diinduksi dengan pemberian alloksan, dan tikus dibagi menjadi beberapa kelompok: kelompok kontrol, kelompok diabetes, dan kelompok perlakuan yang diberi ekstrak buah pala dengan dosis berbeda. Fungsi hati dievaluasi melalui parameter seperti kadar alanin aminotransferase (ALT), aspartat aminotransferase (AST), dan bilirubin, sementara gambaran histopatologi hati dianalisis menggunakan pewarnaan hematoksilin dan eosin. Hasil penelitian menunjukkan bahwa pemberian ekstrak buah pala secara signifikan menurunkan kadar ALT, AST, dan bilirubin, serta memperbaiki gambaran histopatologi hati yang rusak akibat diabetes melitus. Penurunan kerusakan hati ini menunjukkan bahwa ekstrak buah pala memiliki potensi sebagai terapi untuk memperbaiki fungsi hati pada penderita diabetes melitus.
Antidiabetic potential of andaliman: Histopathological and glycemic improvements in diabetic rats Simbolon, Boyke Marthin; Lina, Juliana; Saragih, Ayu Theresia; Bangun, Chrismas Gideon; Nasution, Muhammad Fauzi; Rosari, Anita; Dewani, Yunita; Syahputra, Imam; Silalahi, Todung Donald Aposan
Buletin Kedokteran & Kesehatan Prima Vol. 5 No. 1 (2026): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v5i1.7891

Abstract

Background: Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia and pancreatic dysfunction, particularly involving the Islets of Langerhans. Andaliman (Zanthoxylum acanthopodium) is a plant rich in flavonoids and antioxidants, which are believed to have antidiabetic effects. This study aimed to evaluate the effectiveness of the ethanol extract of Andaliman fruit on pancreatic histopathology in alloxan-induced diabetic rats. Methods: This study employed a true experimental design with a pre-test and post-test control group structure. Twenty-four male Wistar rats were randomly assigned to six groups: a normal control, a positive control (metformin 9 mg/kg), a diabetic control (alloxan 90 mg/kg), and three treatment groups induced with alloxan followed by administration of Andaliman extract at doses of 150, 250, and 350 mg/kg body weight, respectively. Treatments were administered for 14 days, after which blood glucose analysis (pre- and post-treatment) and pancreatic histopathological assessments were performed. Results: Statistical analysis revealed a significant reduction in blood glucose levels following treatment (p = 0.001). Histopathological examination showed that Andaliman extract ameliorated alloxan-induced damage to the Islets of Langerhans. The 350 mg/kg body weight dose resulted in the most pronounced tissue regeneration compared to the other treatment groups. Conclusion: The ethanol extract of Andaliman fruit effectively improves pancreatic histopathology and lowers blood glucose levels in diabetic rats.
Co-Authors Bangun, Chrismas Gideon Dewani, Yunita Lina, Juliana Novita, Cut Elvira Rosari, Anita Saragih, Ayu Theresia Simbolon, Boyke Marthin Syahputra, Imam Todung Donald Aposan Silalahi Widiarini, Kurnia