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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Prima Medika Sains Jurnal Penelitian Pendidikan, Psikologi Dan Kesehatan (J-P3K) Journal of Social Research Buletin Kedokteran dan Kesehatan Prima Jurnal Pendidikan Indonesia (Japendi)
Novita, Cut Elvira
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Laporan kasus: Karsinoma sel skuamosa paru dengan temuan sitologi dan histopatologi Lina, Juliana; Fadillah, Qori; Nadapdap, Marshall Jeremia; Mukti, Ade Indra; Novita, Cut Elvira
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5564

Abstract

Kanker paru-paru sel skuamosa merupakan tantangan klinis yang signifikan dengan prognosis yang buruk. Laporan kasus ini menyajikan seorang pasien dengan gejala khas kanker paru-paru sel skuamosa. Hasil histopatologi mendukung temuan sitologi yakni tampak sebaran dan kelompokan sel epitel skuamous yang atipik dan pleomorfik, inti sel bentuk bulat dan oval, N/C ratio meningkat, kromatin kasar dengan anak inti menonjol, sitoplasma minimal dan eosinofilik. Untuk diagnosa yang lebih pasti dibutuhkan pemeriksaan imunohistokimia p40, p63, CK7, CK5/6 untuk prognosis dan terapi. Namun, sampel jaringan yang sangat sedikit dan tidak cukup untuk prosesing di laboratorium berikutnya, sehingga membutuhkan waktu yang lebih lama untuk tindakan berikutnya pada pasien. Kasus ini menyoroti pentingnya deteksi dini dan penatalaksanaan yang tepat untuk meningkatkan prognosis pasien. Laporan kasus ini memberikan wawasan berharga tentang karakteristik klinis dan tantangan dalam pengelolaan kanker paru-paru sel skuamosa.
Mikroenkapsulasi atenolol dengan penyalut hidroksipropil metilselulosa (HPMC) menggunakan metode emulsifikasi penguapan pelarut Neswita, Elfia; Razoki, Razoki; Tanjung, Fahrul Azmi; Novita, Cut Elvira; Sinaga, Ade Putra Fratama; Samin, Buter
Jurnal Prima Medika Sains Vol. 4 No. 1 (2022): Juni
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v4i1.2261

Abstract

Tujuan utama dari penelitian ini adalah memformulasi mikroenkapsulasi atenolol dengan penyalut HPMC menggunakan metode emulsifikasi penguapan pelarut. Dalan metode ini, HPMC dilarutkan dalam pelarut campuran methanol-diklorometana. Sedangkan atenolol dilarutkan ke dalam larutan HPMC. Dalam gelas lain dimasukkan paraffin cair. Hasil penelitian menunjukkan rasio atenolol dan HPMC adalah 1:0,5; 1:1; dan 1:1,5 berturut-turut untuk masing-masing Formula (Formula I, II, III dan IV). Mikroenkapsulasi yang dihasilkan dievaluasi berdasarkan distribusi ukuran partikel dan senyawa aktif yang dilepaskan. Mikrokapsul memiliki distribusi ukuran partikel antara 212-2000 µm. Spektrofotmeter UV dalam metanol yang digunakan untuk mengukur konsentrasi senyawa aktif diperoleh 56,963 ± 17,589; 60,41 ± 1,0045; 60 dan 173 ± 1,0160 % untuk masing-masing Formula (Formula I, II, dan III). Dapat disimpulkan bahwa mikrokapsul dengan perbandingan atenolol dan HPMC 1:1,5 memiliki pelepasan zat aktif yang lebih baik. Kinetika atenolol yang dilepaskan dari mikrokapsul mengikuti persamaan Higuchi.
Effect of gotu kola leaf extract cream on collagenization and histopathological picture of rat skin exposed to Ultraviolet B light Al Hamid, Muhammad; Novita, Cut Elvira; Wijaya, Johanna Fransiska; Djamin, Djamin
Jurnal Prima Medika Sains Vol. 6 No. 2 (2024): December
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v6i2.5743

Abstract

Changes due to genetic conditions (internal and chronological aging) overlap with aging symptoms triggered by environmental conditions (extrinsic aging). Until recently, exposure to the sun's ultraviolet (UV) radiation was considered the leading cause of extrinsic skin aging; both UVB (290-320 nm) and UVA (320-400 nm) caused photoaging, and due to their physical properties, UVB radiation was especially harmful to the skin condition. This study aims to analyze and test the effect of administering gotu kola leaf extract cream (Ceentella asiatica) on collagenization in Wistar rats (Rattus norvegicus) exposed to ultraviolet-B light. This study uses a posttest-only control group design, where only observations are made to the control group and treatment after the treatment is given. The research results show that gotu kola leaf extract contains phytochemicals that can be used as an antioxidant and anti-inflammatory ingredient because they contain flavonoids, saponins, tannins, and phenolic compounds. This research concludes that pegagan leaf extract contains phytochemicals that can be used as medicinal ingredients because it contains high antioxidant and anti-inflammatory compounds. The average percentage of collagen growth in the control group compared to treatment groups P1, P2, and P3 after exposure to UVB light was very high, and the group control of collagen growth was not significant and tended to be stable.
Pengaruh Ekstrak Buah Pala (Myrisca Fragnant Houtt) Terhadap Fungsi Dan Gambaran Hispatologi Hati Tikus Penderita Diabetes Melitus Widiarini, Kurnia; Nasution, Muhammad Fauzi; Novita, Cut Elvira
JURNAL PENELITIAN PENDIDIKAN, PSIKOLOGI DAN KESEHATAN (J-P3K) Vol 6, No 2 (2025): J-P3K
Publisher : Yayasan Mata Pena Madani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51849/j-p3k.v6i2.762

Abstract

Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak buah pala (Myristica fragrans Houtt.) terhadap fungsi hati dan gambaran histopatologi hati pada tikus putih galur Wistar jantan yang mengalami diabetes melitus. Diabetes melitus diinduksi dengan pemberian alloksan, dan tikus dibagi menjadi beberapa kelompok: kelompok kontrol, kelompok diabetes, dan kelompok perlakuan yang diberi ekstrak buah pala dengan dosis berbeda. Fungsi hati dievaluasi melalui parameter seperti kadar alanin aminotransferase (ALT), aspartat aminotransferase (AST), dan bilirubin, sementara gambaran histopatologi hati dianalisis menggunakan pewarnaan hematoksilin dan eosin. Hasil penelitian menunjukkan bahwa pemberian ekstrak buah pala secara signifikan menurunkan kadar ALT, AST, dan bilirubin, serta memperbaiki gambaran histopatologi hati yang rusak akibat diabetes melitus. Penurunan kerusakan hati ini menunjukkan bahwa ekstrak buah pala memiliki potensi sebagai terapi untuk memperbaiki fungsi hati pada penderita diabetes melitus.
Analisis Faktor Resiko Diabetes Melitus Tipe 2 Pada Kelompok Umur Dewasa di Rumah Sakit Umum Royal Prima Ayahanda Periode Januari 2023 – Desember 2024 Ginting's, Varian Christhoper; Baeha, Ferdinando Motuho; Novita, Cut Elvira
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i10.62241

Abstract

Type 2 Diabetes Mellitus (Type 2 DM) is a chronic metabolic disease characterized by hyperglycemia due to insulin resistance and impaired insulin secretion. The disease is increasing in prevalence, especially in the adult age group, so it is important to identify the risk factors that play a role in the occurrence of Type 2 DM. This study aims to analyze the relationship of risk factors such as age, sex, history of hypertension, family history of DM, and body mass index (BMI) to the incidence of Type 2 DM in patients at Royal Prima Ayahanda Hospital Medan. This study uses an analytical observational design with a cross sectional approach. Data were obtained from the medical records of patients treated with a diagnosis of Type 2 DM in the period January 2023–December 2024. The sample was determined by purposive sampling technique, involving 44 patients aged 40–65 years who met the inclusion criteria. Data analysis was carried out using the chi-square test with the help of SPSS. The results showed that the majority of patients were in the age group of 50–59 years (47.7%), with a higher proportion of women (61.4%). Age, sex, and history of hypertension were not significantly associated with the incidence of Type 2 DM (p>0.05). In contrast, family history of DM (p=0.032) and BMI (p=0.012) showed a significant association with the incidence of Type 2 DM. Patients who are overweight and obese have a higher risk of developing Type 2 DM, as do individuals with a family history of DM. These findings confirm the importance of prevention through weight control and early detection in individuals with a family history of DM. This research is expected to be a reference for health workers in public education and risk factor-based interventions.
Laporan kasus: Karsinoma sel skuamosa paru dengan temuan sitologi dan histopatologi Lina, Juliana; Fadillah, Qori; Nadapdap, Marshall Jeremia; Mukti, Ade Indra; Novita, Cut Elvira
Buletin Kedokteran & Kesehatan Prima Vol. 3 No. 1 (2024): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v3i1.5564

Abstract

Kanker paru-paru sel skuamosa merupakan tantangan klinis yang signifikan dengan prognosis yang buruk. Laporan kasus ini menyajikan seorang pasien dengan gejala khas kanker paru-paru sel skuamosa. Hasil histopatologi mendukung temuan sitologi yakni tampak sebaran dan kelompokan sel epitel skuamous yang atipik dan pleomorfik, inti sel bentuk bulat dan oval, N/C ratio meningkat, kromatin kasar dengan anak inti menonjol, sitoplasma minimal dan eosinofilik. Untuk diagnosa yang lebih pasti dibutuhkan pemeriksaan imunohistokimia p40, p63, CK7, CK5/6 untuk prognosis dan terapi. Namun, sampel jaringan yang sangat sedikit dan tidak cukup untuk prosesing di laboratorium berikutnya, sehingga membutuhkan waktu yang lebih lama untuk tindakan berikutnya pada pasien. Kasus ini menyoroti pentingnya deteksi dini dan penatalaksanaan yang tepat untuk meningkatkan prognosis pasien. Laporan kasus ini memberikan wawasan berharga tentang karakteristik klinis dan tantangan dalam pengelolaan kanker paru-paru sel skuamosa.
Overview of Risk Factors for Cholelytasis Patients at Royal Prima Medan Hospital in 2022-2023 Iatassomi, Syakira; Baeha, Ferdinando Motuho; Novita, Cut Elvira
Journal of Social Research Vol. 4 No. 11 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i10.2845

Abstract

This study aims to provide an overview of the risk factors associated with cholelithiasis among patients treated at Royal Prima Hospital Medan during 2022–2023. Using a quantitative approach with a cross-sectional design, data were collected simultaneously from patient medical records to identify and describe risk characteristics. The research population included all patients diagnosed with cholelithiasis within the specified period, while the sampling technique employed was proportional random sampling. Data were obtained through documentation methods and analyzed using univariate descriptive statistics to present the distribution of each variable. The findings revealed that the majority of patients were female (59.7%), aged over 40 years (68.1%), had a family history of cholelithiasis (90.3%), and were overweight (45.8%). Body mass index (BMI) analysis showed that 45.8% of patients were overweight, 36.1% had normal BMI, and 18.1% were obese, with no underweight cases identified. The results are expected to highlight key factors such as age range, body mass index (BMI), and family medical history contributing to the occurrence of cholelithiasis. This study provides valuable insights for healthcare providers in improving preventive strategies and promoting public awareness regarding the risk factors for cholelithiasis.
The Relationship of Earphone Use to the Occurrence of Noise-Related Hearing Loss in Students of the Faculty of Medicine, Universitas Prima Class of 2022 Salsabila, Sri; Novita, Cut Elvira; Baeha, Ferdinando Motuho
Jurnal Pendidikan Indonesia Vol. 6 No. 12 (2025): Jurnal Pendidikan Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/japendi.v6i12.8905

Abstract

The widespread use of earphones among college students, especially with high volume and long duration, increases the risk of noise-induced hearing loss (NIHL). Global data show that adolescents and young adults are a vulnerable group, but there are still limited studies examining the relationship between earphone use patterns and audiometry results in medical students in Indonesia. This study aims to analyze the relationship between the use of earphones and noise-induced hearing loss in students of the Faculty of Medicine, Universitas Prima Indonesia. Using observational analytical approaches and cross-sectional designs, data were collected through questionnaires and audiometric examinations on 20 respondents. The results showed that there was a significant relationship between the duration of earphone use and hearing loss (p = 0.010), while the frequency of earphone use did not show a significant relationship (p = 0.543). These results provide important evidence regarding the impact of earphone use on students' hearing health. This research is expected to be the basis for educational institutions to develop educational programs regarding the safe use of earphones to prevent hearing loss.
Co-Authors Al Hamid, Muhammad Baeha, Ferdinando Motuho Djamin, Djamin Fadillah, Qori Ginting's, Varian Christhoper Iatassomi, Syakira Lina, Juliana Mukti, Ade Indra Nadapdap, Marshall Jeremia Nasution, Muhammad Fauzi Neswita, Elfia Razoki, Razoki Salsabila, Sri Samin, Buter Sinaga, Ade Putra Fratama Tanjung, Fahrul Azmi Widiarini, Kurnia Wijaya, Johanna Fransiska