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Siti Zamilatul Azkiyah
Universitas Ibrahimy Situbondo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Journal of Life Science and Technology

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Potensi Coriatin dan Coriamyrtin Helixanthera sessiliflora (Merr.) Denser sebagai Kandidat Obat Penurun Hipertensi; Kajian in silico Dewi Ratih Tirto Sari; Maulidia Riska Pratiwi; Heny Yusuf; Siti Zamilatul Azkiyah
BIOMARAS : Journal of Life Science and Technology Vol 2 No 1 (2024): BIOMARAS : Vol 2, No 1 Februari 2024
Publisher : BIOMARAS : Journal of Life Science and Technology

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Abstract

This study investigated bioactive compounds from Loranthaceae as antihypertension drug candidates through in silico approach. Coriatin and coriamyrtin structure as a targeted ligand was carried out from PubChem NCBI, lisinopril as a native ligand for control was used in this study. Targeted protein that chose for hypertension was angiotensin converting enzyme (ACE), which retrieved from protein data bank. Ligands and protein were docked by Molegro virtual docker version 5.0 and analyzed by PyMol 2.3 and Discovery studio version 21.1.1. docking results showed that coriatin and coriamyrtin posed interaction at the same sites of ACE protein as well as lisinopril. Some active residues of lisinopril that identified on coriatin were GLN281, HIS383, and TYR520, while residues of coriamyrtin that were same as lisinopril were GLU384, GLU411, HIS513, and HIS387. The same binding sites of coriatin and coriamyrtin with lisinopril indicated that both of compounds have potential activity as well as lisinopril. In conclusion, coriatin and coriamyrtin were potentially as antihypertension drug candidates. Further in vivo and in vitro should be conducted for future investigation.
Co-Authors Afza, Hadfina Choirunniza, Aqidatun Naffiah Delvi Noer Kholida Rahmaniyah Dessy Dwi Risky Ayuningtias Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Diana Lady Yunita Handoyo Febriyantika, Cindy Farid Hayatul Rahimah Heny Yusuf Ismatun Wafiyah Istiana Istiana Lailatus Sarifah Laily, Siti Maulidia Riska Pratiwi Muhammad Eko Pranoto Pranoto, M. Eko Raodatul Jannah Sari, Dewi Ratih Tirto Siti Mufarohah SRI NUR ATIQAH Ustiatik, Reni Yohanes Bare