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Siti Zamilatul Azkiyah
Universitas Ibrahimy Situbondo
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : PARADIGM : JOURNAL OF MULTIDISCIPLINARY RESEARCH AND INNOVATION

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MULTIDRUG-RESISTANT AND EXTENSIVELY DRUG-RESISTANT TUBERCULOSIS IN INDONESIA: A CRITICAL REVIEW OF TRENDS, DETERMINANTS AND CONTROL STRATEGIES Azkiyah, Siti Zamilatul
PARADIGM : Journal Of Multidisciplinary Research and Innovation Vol 3 No 02 (2025): PARADIGM : Journal Of Multidisciplinary Research and Innovation
Publisher : Pusat Studi Ekonomi Publikasi Ilmiah dan Pengembangan SDM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62668/paradigm.v3i02.2203

Abstract

Multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) pose major challenges to tuberculosis control in Indonesia, a country with one of the highest TB burdens globally. This review critically examines trends, determinants, and control strategies of MDR/XDR-TB in Indonesia. A narrative critical review was conducted using national and international literature published over the last 10–15 years, focusing on epidemiology, risk factors, diagnostic approaches, and treatment outcomes. The findings indicate that previous TB treatment, poor treatment adherence, and comorbidities such as diabetes mellitus are key determinants of drug resistance. Although molecular diagnostic tools have improved early detection, unequal access and health system limitations persist. New therapeutic regimens offer improved outcomes but remain constrained by adherence issues and emerging resistance. An integrated, evidence-based approach addressing clinical, social, and system-level factors is essential to strengthen MDR/XDR-TB control in Indonesia.
Co-Authors Afza, Hadfina Choirunniza, Aqidatun Naffiah Delvi Noer Kholida Rahmaniyah Dessy Dwi Risky Ayuningtias Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Dewi Ratih Tirto Sari Diana Lady Yunita Handoyo Febriyantika, Cindy Farid Hasan, Rahmawaty Hayatul Rahimah Ismatun Wafiyah Istiana Istiana Lailatus Sarifah Laily, Siti Muhammad Eko Pranoto Pranoto, M. Eko Pratiwi, Maulidia Riska Raodatul Jannah Sari, Dewi Ratih Tirto Siti Mufarohah SRI NUR ATIQAH Ustiatik, Reni Yohanes Bare Yusuf, Heny