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All Journal Promotif: Jurnal Kesehatan Masyarakat Jurnal Ilmiah Ecosystem
Hardjo, Marhaen
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Law, Crime, Criminology & Criminal Justice Public Health Social Sciences

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Review Artikel: Teknik -Teknik Analisis Profil Mikrobiota Penyebab Karies Ibrahim, Sukaeni; Hardjo, Marhaen
Jurnal Ilmiah Ecosystem Vol. 22 No. 3 (2022): ECOSYSTEM Vol. 22 No 3, September-Desember Tahun 2022
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35965/eco.v22i3.2106

Abstract

Karies gigi merupakan penyakit infeksi kronis yang umum terjadi akibat bakteri kariogenik yang melekat pada gigi. Mikroorganisme kariogenik berperan penting dalam perkembangan karies. Streptococcus mutan merupakan mikroorganisme pathogen penting dalam perkembangan lesi karies. Perkembangan terbaru dalam teknologi sekuensing DNA belakangan ini telah memungkinkan untuk memetakan profil komposisi mikrobioma rongga mulut dan memberikan harapan dalam menyelesaikan penyakit menular ini. Pada penelitian ini, kami mengumpulkan data penelitian mengenai teknik analisis profil mikrobioma rongga mulut melalui mesin pencarian online Google Scholar dan Pubmed. Dan didapatkan 15 jurnal yang membahas mengenai teknik identifikasi mikrobioma rongga mulut. Teknik analisis mikrobioma rongga mulut dapat diketahui dengan jelas beserta kelebihan dan kekurangan untuk merancang penelitian lebih lanjut tentang mikrobioma penyebab terjadinya karies. Dental caries is a common chronic infectious resulting from tooth adherent cariogenic bacteria. The cariogenic microorganisms play an important part in caries development. Streptococcus mutan is an important pathogenic organism in the development of caries lesion. The development of dental caries is highly associated with the microbiota in the oral cavity. Recent developments in DNA sequencing technology have made it possible to map the compositional profile of the oral microbiome and provide hope in solving the problem on this infectious disease. The development of dental caries is closely related to the microbiota in the oral cavity. Recent developments in DNA sequencing technology have made it possible to map the compositional profile of the oral microbiome and provide hope in solving this infectious disease problem. Methode: In this study, we collected research data regarding the technique of analyzing oral microbiome profiles through the online search engines Google Scholar and Pubmed. And obtained 15 journal that discuss the identification technique of the oral microbiome Result: The oral microbiome analysis technique can be identified clearly along with its advantages and disadvantages for design further research on the microbiome that causes caries.
Wound healing activity of Combination Propolis and Coconut Shell Liquid Smoke Ointment on wistar rat second degree Burns wound models chandrawati, Aida ayu; Hardjo, Marhaen; Kadir, Syahrijuita
Promotif : Jurnal Kesehatan Masyarakat Vol. 15 No. 1: JUNE 2025
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/promotif.v15i1.6570

Abstract

Introduction: The delay in burns healing is a serious complication that can lead to disability and death. TGF-?1 contributes significantly to the wound healing process. Chronic wounds that do not heal often indicate a loss of TGF-?1 signaling. Propolis and coconut shell liquid smoke (CS-LS) are natural ingredients that contain antioxidant, anti-inflammatory, and analgesic compounds to accelerate wound healing. This study aimed to prove the effectiveness of using a topical combination of propolis and CS-LS in accelerating the healing process of degree II burns and their relationship with the expression of TGF-?1 in serum. Method: A 14-day in vivo experimental investigation using Wistar rats was carried out with a total sample of 25 rats divided into 4 groups.; Group 1, treated with sulfadiazine ointment; Group 2, treated with propolis ointment; Group 3, treated with CS-LS ointment; Group 4, treated with the combination of propolis and CS-LS ointment, and 1 control group without treatment. Serum TGF-?1 levels were determined by ELISA. Result: Measurements of wound size were on days 0,3,7 and 14. This study obtained results the combination ointment group alone had significantly different TGF-?1 levels from day 7 to day 14 and experienced a decrease in TGF-?1 levels of 52.28 ?/mg. Based on wound size, there was a significant difference in all groups (p<0.05), this was supported by the mean value of wound size which was smaller in the sulfadiazine ointment group and the combination (propolis and liquid smoke) ointment group. Conclusion: The combination of propolis and coconut shell liquid smoke can be considered as an alternative in the treatment of second degree burns because of its ability to reduce TGF-?1 and accelerate burn wound healing. Keywords: wound healing, propolis, coconut shell liquid smoke, TGF-?1
Co-Authors Chandrawati, Aida Ayu Ibrahim, Sukaeni Kadir, Syahrijuita