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All Journal Promotif: Jurnal Kesehatan Masyarakat Jurnal Ilmiah Ecosystem Journal Of World Science Bosowa Medical Journal JI-KES (Jurnal Ilmu Kesehatan)
Hardjo, Marhaen
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Agriculture, Biological Sciences & Forestry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Review Artikel: Teknik -Teknik Analisis Profil Mikrobiota Penyebab Karies Ibrahim, Sukaeni; Hardjo, Marhaen
Jurnal Ilmiah Ecosystem Vol. 22 No. 3 (2022): ECOSYSTEM Vol. 22 No 3, September-Desember Tahun 2022
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35965/eco.v22i3.2106

Abstract

Karies gigi merupakan penyakit infeksi kronis yang umum terjadi akibat bakteri kariogenik yang melekat pada gigi. Mikroorganisme kariogenik berperan penting dalam perkembangan karies. Streptococcus mutan merupakan mikroorganisme pathogen penting dalam perkembangan lesi karies. Perkembangan terbaru dalam teknologi sekuensing DNA belakangan ini telah memungkinkan untuk memetakan profil komposisi mikrobioma rongga mulut dan memberikan harapan dalam menyelesaikan penyakit menular ini. Pada penelitian ini, kami mengumpulkan data penelitian mengenai teknik analisis profil mikrobioma rongga mulut melalui mesin pencarian online Google Scholar dan Pubmed. Dan didapatkan 15 jurnal yang membahas mengenai teknik identifikasi mikrobioma rongga mulut. Teknik analisis mikrobioma rongga mulut dapat diketahui dengan jelas beserta kelebihan dan kekurangan untuk merancang penelitian lebih lanjut tentang mikrobioma penyebab terjadinya karies. Dental caries is a common chronic infectious resulting from tooth adherent cariogenic bacteria. The cariogenic microorganisms play an important part in caries development. Streptococcus mutan is an important pathogenic organism in the development of caries lesion. The development of dental caries is highly associated with the microbiota in the oral cavity. Recent developments in DNA sequencing technology have made it possible to map the compositional profile of the oral microbiome and provide hope in solving the problem on this infectious disease. The development of dental caries is closely related to the microbiota in the oral cavity. Recent developments in DNA sequencing technology have made it possible to map the compositional profile of the oral microbiome and provide hope in solving this infectious disease problem. Methode: In this study, we collected research data regarding the technique of analyzing oral microbiome profiles through the online search engines Google Scholar and Pubmed. And obtained 15 journal that discuss the identification technique of the oral microbiome Result: The oral microbiome analysis technique can be identified clearly along with its advantages and disadvantages for design further research on the microbiome that causes caries.
Wound healing activity of Combination Propolis and Coconut Shell Liquid Smoke Ointment on wistar rat second degree Burns wound models chandrawati, Aida ayu; Hardjo, Marhaen; Kadir, Syahrijuita
Promotif : Jurnal Kesehatan Masyarakat Vol. 15 No. 1: JUNE 2025
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/promotif.v15i1.6570

Abstract

Introduction: The delay in burns healing is a serious complication that can lead to disability and death. TGF-?1 contributes significantly to the wound healing process. Chronic wounds that do not heal often indicate a loss of TGF-?1 signaling. Propolis and coconut shell liquid smoke (CS-LS) are natural ingredients that contain antioxidant, anti-inflammatory, and analgesic compounds to accelerate wound healing. This study aimed to prove the effectiveness of using a topical combination of propolis and CS-LS in accelerating the healing process of degree II burns and their relationship with the expression of TGF-?1 in serum. Method: A 14-day in vivo experimental investigation using Wistar rats was carried out with a total sample of 25 rats divided into 4 groups.; Group 1, treated with sulfadiazine ointment; Group 2, treated with propolis ointment; Group 3, treated with CS-LS ointment; Group 4, treated with the combination of propolis and CS-LS ointment, and 1 control group without treatment. Serum TGF-?1 levels were determined by ELISA. Result: Measurements of wound size were on days 0,3,7 and 14. This study obtained results the combination ointment group alone had significantly different TGF-?1 levels from day 7 to day 14 and experienced a decrease in TGF-?1 levels of 52.28 ?/mg. Based on wound size, there was a significant difference in all groups (p<0.05), this was supported by the mean value of wound size which was smaller in the sulfadiazine ointment group and the combination (propolis and liquid smoke) ointment group. Conclusion: The combination of propolis and coconut shell liquid smoke can be considered as an alternative in the treatment of second degree burns because of its ability to reduce TGF-?1 and accelerate burn wound healing. Keywords: wound healing, propolis, coconut shell liquid smoke, TGF-?1
Combination of Stem Cell & PRP Therapy in Healthy Aging for Osteoarthritis Susanti Vinski, Deby; Cinta Vinski, Natasha; Sintong, Langga; Hardjo, Marhaen
Journal of World Science Vol. 3 No. 2 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i2.539

Abstract

Osteoarthritis is the most common inflammation of the joints, with symptoms of joint pain when moving, stiffness, especially in the morning, weakening of the muscles around the problematic joint, sound when the joint is moved, and swelling in the joint area. The absence of treatment that can eliminate Osteoarthritis has led to an increasing demand for more effective treatment. In fact, common disease is age-related, and global statistics show that it is a significant health problem and financial burden on health and social welfare systems globally. This study aims to explain and analyze the effectiveness of combination therapy of stem cells and PRP in the treatment of Osteoarthritis. The research method used is a case study where combination therapy of stem cells and PRP offers the potential to modify the natural recovery of knee Osteoarthritis using stem cell-based technology. Stem cell therapy was given to 9 Osteoarthritis patients aged over 50 years, most of whom were female, who were proven to tend to improve their condition after undergoing stem cell therapy with PRP at the Vinski Regenerative Center and were able to carry out their daily activities again.
Application of Mesenchymal Stem Cell for Degenerative Disc Disease Susanti Pada Vinski, Deby; Siagian, Carles; Kurniawan Nugroho, Andi; Hardjo, Marhaen; Cinta Vinski, Natasha
Journal of World Science Vol. 3 No. 3 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i3.562

Abstract

During a person's life, the spine will experience continuous changes in response to physiological axial loads. Increasing age is also a cause of pathological degenerative changes. Degenerative disease of the spine is a condition that many people complain about and requires appropriate and effective treatment. Degenerative disc disease is the most common cause of low back pain and disability worldwide, involving people of all ages and socioeconomic statuses. This study aims to explain and analyze the effectiveness of Mesenchymal Stem Cell therapy in treating Degenerative Disc Disease. The research method used is a case study where  Mesenchymal Stem Cell therapy offers the potential to modify the natural recovery of Degenerative Disc Disease using stem cell-based technology. Case studies were carried out at the Vinski Regenerative Center clinic, on several patients. And the results are that stem cells have the potential to be an ideal non-surgical treatment for low back pain and degenerative disc disease, because of their ability to differentiate into various connective tissue cells and their ability to restore damaged tissue and the results of case studies have proven to tend to improve the condition. However, long-term clinical studies are still needed, specifically focusing on the safety and efficacy of stem cell therapy in degenerative disc disease.
Quantum Stem Cell Therapy for Recovery of Liver Disease Susanti Vinski, Deby; Schroeter, CA; Hardjo, Marhaen; Kurniawan Nugroho, Andi; Cinta Vinski, Natasha
Journal of World Science Vol. 3 No. 5 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i5.609

Abstract

Chronic liver diseases pose a significant global health challenge, necessitating the development of novel therapeutic strategies for liver regeneration and functional recovery. Mesenchymal stem cells (MSCs) derived from umbilical cord blood have emerged as promising candidates for liver regeneration due to their multipotent differentiation capacity, immunomodulatory properties, and paracrine effects. This study aims to investigate the efficacy, safety, and underlying mechanisms of stem cell therapy in the recovery and regeneration of liver tissue in patients with liver disease. The research method used is a case study where Mesenchymal Stem Cell therapy offers the potential to modify the natural recovery of Liver function using stem cell-based technology. Case studies were carried out on several Vinski Regenerative Center clinic patients. This review explores the therapeutic potential of umbilical cord blood-derived MSCs in promoting the recovery of liver function in preclinical and clinical settings. We discuss the mechanisms by which MSCs facilitate liver regeneration, including their ability to differentiate into hepatocyte-like cells, modulate immune responses, and secrete trophic factors that promote tissue repair. Preclinical studies demonstrate the efficacy of umbilical cord blood-derived MSCs in ameliorating liver injury, reducing fibrosis, and improving overall liver function. Challenges such as optimal dosing, timing of administration, and long-term monitoring remain to be addressed. Nevertheless, MSCs from umbilical cord blood represent a promising therapeutic approach for liver regeneration and hold great potential for improving outcomes in patients with liver disease.
Stem Cell Therapy For Men’s Vitality: A Comprehensive Review And Meta-Analysis Susanti Vinski, Deby; Quintosa , Jaime Rodriguez; Trofimova , Svetlana; Nugroho, Andi Kurniawan; Vinski, Natasha Cinta; Hardjo, Marhaen
Journal of World Science Vol. 3 No. 9 (2024): Journal of World Science
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jws.v3i9.722

Abstract

One of the many potential benefits of stem cell therapy is that it may enhance men’s vitality by addressing conditions such as erectile dysfunction and hypogonadism. The current comprehensive review and meta-analysis evaluate the efficacy, safety, and mechanisms of stem cell therapy in improving male sexual health. Data from previously published clinical trials, reviews, and preclinical studies indicate that stem cell therapy significantly enhances erectile function, increases testosterone levels, and improves sperm quality. The regenerative potential of mesenchymal stem cells (MSCs), including their ability to differentiate into various cell types and secrete bioactive molecules, underpins these benefits. Additionally, MSCs modulate the immune response, reducing inflammation and promoting tissue repair. Despite these promising results, current research is limited by heterogeneity among studies, lack of long-term data, and the absence of standardized treatment protocols. Future research can focus on large-scale randomized controlled trials with standardized protocols to validate the long-term efficacy and safety of stem cell therapy. The results of the review support the potential of stem cell therapy as a novel approach in regenerative medicine, offering innovative solutions for men’s health and vitality. Addressing the current limitations and exploring future directions will pave the way for the clinical adoption of stem cell therapy, advancing the treatment options for conditions affecting men’s vitality and improving the quality of life for millions of men worldwide.
Hal-Hal Yang Ada Hubungan Dengan Serangan Asma Atopik Pada Penderita Anak Di Berbagai Lokasi Di Dunia Periode Tahun 1998 Sampai Dengan Tahun 2019 Akbar, Moh.Fahmi; Hardjo, Marhaen; Rahmadani, Annisa Rahmadani
Bosowa Medical Journal Vol. 2 No. 1 (2024): Bosowa Medical Journal Januari 2024
Publisher : Fakultas Kedokteran Universitas Bosowa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56326/bmj.v2i1.1630

Abstract

An atopic asthma attack is an episode of progressive increase (worsening) of symptoms of cough, shortness of breath, wheezing, chest tightness, or any combination of these symptoms as a result of an exaggerated immune response or hypersensitivity reaction involving an allergic response that produces antibodies. IgE specific to antigen. This study aims to determine the things that have a relationship with atopic asthma attacks. This research is a systematic review research by processing the results obtained from ten scientific research journals with a case control research design. Based on ten studies analyzed, it shows that there are things that have a relationship with atopic asthma attacks in pediatric patients in various locations in the world, namely there is a significant relationship between atopy history, house dust mites, weather changes, pollutants, and pollen on atopic asthma attacks with p value < 0.01. Meanwhile, there is no significant relationship between pet factors and atopic asthma attacks with p value > 0.01.: Based on this study, it is known that things that have a relationship with atopic asthma attacks in pediatric patients in various locations in the world from 1998 to 2019 are a history of atopy, house dust mites, weather changes, pollutants, and pollen.
Efek Restriksi Kalori dan Restriksi Kalori Mimetic pada Tikus Tua Nurliana, Nurliana; Syahrijuita, Syahrijuita; Yustisia, Ika; Kwenang, Agnes; Hardjo, Marhaen; Soraya, Gita Vita
JI-KES (Jurnal Ilmu Kesehatan) Vol. 5 No. 2 (2022): JI-KES (Jurnal Ilmu Kesehatan)
Publisher : LPPM Universitas Hafshawaty Zainul Hasan Probolinggo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33006/ji-kes.v5i2.343

Abstract

AbstrakSecara global sekitar 2,3 miliar lansia mengalami overweight dan obesitas. Restriksi kalori adalah intervensi yang berpengaruh untuk memperpanjang hidup, namun sulit bagi setiap orang untuk menerapkan restriksi kalori seumur hidup. Oleh karena itu diperlukan intervensi lain yang memiliki manfaat sama dengan restriksi kalori. Penelitian ini bertujuan untuk mengetahui pengaruh restriksi kalori, dan  restriksi  kalori mimetik terhadap profil lipid tikus tua. Penelitian ini termasuk penelitian eksperimental menggunakan metode acak terkontrol dengan Pre and Post test with controlled group design. Menggunakan 18 ekor tikus dibagi menjadi 3 kelompok, A (kontrol), B (restriksi kalori), dan C (restriksi kalori mimetik) dan tiap kelompok terdiri dari 6 ekor tikus. Uji One Way Anova digunakan untuk melihat perbedaan sebelum dan sesudah intervensi. Dari hasil uji perbandingan secara keseluruhan terdapat perbedaan kolesterol, trygliserida, LDL-Cholesterol, HDL-Cholesterol serum tikus antara kelompok A,B, dan C setelah 30 hari perlakuan dengan nilai p<0.005. Dari hasil penelitian dapat disimpulkan bahwa restriksi kalori dan restriksi kalori mimetik mempengaruhi profil lipid. Kata kunci : restriksi kalori, restriksi kalori mimetik, profil lipid, penuaan AbstractGlobally around 2.3 billion elderly are overweight and obese. Calorie restriction is a powerful intervention for prolonging life, but it is difficult for everyone to implement calorie restriction for life. Therefore, other interventions are needed that have the same benefits as calorie restriction. This study aims to determine the effect of calorie restriction, and mimetic calorie restriction on the lipid profile of elderly rats and includes an experimental study using a randomized controlled method with Pre and Post test with controlled group design. Using 18 rats were divided into 3 groups, A (control), B (calorie restriction), and C (mimetic calorie restriction) and each group consisted of 6 rats. One Way Anova test was used to see the difference before and after the intervention. From the results of the overall comparison test, there were differences in cholesterol, triglycerides, LDL-Cholesterol, HDL-Cholesterol in rat serum between groups A, B, C, and D after 30 days of treatment with p < 0,005. From the results of the study it can be concluded that calorie restriction and mimetic calorie restriction affect the lipid profile. Keywords: calorie restriction, mimetic calorie restriction, intermittent fasting, lipid profile, aging
Co-Authors Akbar, Moh.Fahmi Andi Kurniawan Nugroho Carles Siagian, Carles Chandrawati, Aida Ayu Cinta Vinski, Natasha Ibrahim, Sukaeni Kadir, Syahrijuita Kurniawan Nugroho, Andi Kwenang, Agnes NURLIANA NURLIANA Quintosa , Jaime Rodriguez Rahmadani, Annisa Rahmadani Schroeter, CA Sintong, Langga Soraya, Gita Vita Susanti Pada Vinski, Deby Susanti Vinski, Deby Syahrijuita, Syahrijuita Trofimova , Svetlana Vinski, Natasha Cinta Yustisia, Ika