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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Folia Medica Indonesiana
Rahmadani, Rizal Umar
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Health Professions Medicine & Pharmacology Other

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Drug utilization of corticosteroid in post-operative cataract patients at Klinik Mata Utama (KMU) Madura Solihah, Riyadatus; Rahmadani, Rizal Umar; Puspitasari, Dianita Rahayu
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 14, No 1 (2023): June 2023
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v14i1.28054

Abstract

A cataract is contributed to 51% of blindness in the world. Cataract surgery is needed to restore the normal eye function. Therapeutic management post cataract operative is generally carried out 1-4 weeks by administering antibiotics, corticosteroids or NSAIDs by oral or topical routes. Corticosteroids administration increase intraocular pressure (IOP), therefore should be taken into account in post-operative cataract. The aim of this study was to observe the pattern of corticosteroid use in post-cataract surgery patients at the Klinik Mata Utama (KMU) Madura. Observational retrospective research involved 153 patients who consumed corticosteroids during their post operative cataract period. The results showed that 122 patients (79.7%) received combination therapy of topical dexamethasone and oral methylprednisolone, while 31 (20.3%) received combination therapy of topical dexamethasone and oral prednisone. 140 Patients (91,6%) showed good recovery with corticosteroids, and 13 patients (8,4%) experienced the IOP as a side effect of topical corticosteroids. In conclusion, the corticosteroids therapy for post-operative cataract patients should be managed properly to prevent the side effects of increasing IOP.
PHOSPHATIDYLGLYCEROL STUDY AS FETAL LUNG MATURATION PARAMETER AFTER DEXAMETHASONE ADMINISTRATION FOR WOMEN AT RISK OF PRETERM BIRTH Rahmadani, Rizal Umar; Sulistyono, Agus; Yulistiani, Yulistiani; Yahya, Muhammad
Folia Medica Indonesiana Vol. 52 No. 4 (2016): OCTOBER - DECEMBER 2016
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (87.397 KB) | DOI: 10.20473/fmi.v52i4.5473

Abstract

Phosphatidylglycerol is an important indicator of fetal lung maturation, which plays a role in stabilizing surfactant lipoprotein complex. Corticosteroid antenatal can stimulate the synthesis of pulmonary surfactant in infants with preterm birth. The objective of this study is to examine the phosphatidylglycerol levels as fetal lung maturation parameter after dexamethasone administration in women with preterm birth compared to L/S ratio parameter. This study was prospective longitudinal (cohort). The samples were pregnant women with preterm birth risk at 28-34 weeks gestation getting the therapy of antenatal dexamethasone 6 mg IM every 12 hours given 4 times in 48 hours. The samples were 17 patients. Determination of L/S ratio and PG levels was performed by ELISA. The study was conducted from May - November 2015 and reviewed to obtain ethics eligibility permit by the research ethic committees of Dr. Soetomo General Hospital. The results show that the mean value of L/S ratio is 2.28 with a range of 1.35 to 9.06 and the mean of PG level is 1.17 with a range from 0 to 3.79. L/S ratio and PG show no significant relationship between the two of them. Increased levels of PG on the gestational age of 28-32 weeks have not demonstrated clinically significant changes yet. The highest PG level occurs in the gestational age of 32-34 weeks.
Co-Authors Agus Sulistyono Muhammad Yahya Puspitasari, Dianita Rahayu Solihah, Riyadatus Yulistiani Yulistiani, Yulistiani