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All Journal Mutiara Medika: Jurnal Kedokteran dan Kesehatan Journal of Ocean, Mechanical and Aerospace -science and engineering- (JOMAse)
Juliadmi, Dian
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Aerospace Engineering Decision Sciences, Operations Research & Management Engineering Health Professions Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology

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The Cytotoxicity of Agaro-Oligosaccharides and Neoagaro-Oligosaccharides on Macrophage Cells Pratitis, Visi Endah; Puspitasari, Pinki Anggrahini; Hanbal, Mayland Muhammad; Tsabitah, Khansa; Juliadmi, Dian; Saksono, Budi; Wijayanti, Nastiti
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 24, No 2 (2024): July
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v24i2.21059

Abstract

Agarose is a polysaccharide from red algae. Enzymatic hydrolysis of agarose can produce Agaro-Oligosaccharidess (AOS) and Neoagaro-Oligosaccharidess (NAOS). Different times of enzymatic hydrolysis can produce different types of AOS and NAOS based on their degree of polymerization (DPs). This study aims to examine the cytotoxicity of AOS and NAOS with different hydrolysis times on the macrophage cell line RAW 264.7. The parameters used were the percentage of cell viability and IC50 value. The cytotoxicity test using MTT assay and One-way ANOVA were used as statistical tests. The results showed that AOS-0 at a concentration below 125 µg/mL was not toxic and showed moderate toxicity up to a high concentration of 1000 µg/mL, while AOS hydrolyzed for 24 h (AOS-24) was not toxic to RAW 264.7 cells at all concentrations tested. The different results were shown in all NAOS samples, which were highly toxic to RAW 264.7 cells in the 125 to 1000 µg/mL, indicating that it was concentration dependent. The results showed that different hydrolysis times caused differences in the structure of AOS and NAOS compounds and influenced the toxicity level. Research development for further studies on antioxidants and anti-inflammatory needs more attention to the sample type and hydrolysis time.
Hydroxyapatite Bilayers Coating on Screw Implant Ti6Al4V ELI with Electrophoretic Deposition Method for Improving Osseointegration Juliadmi, Dian; Oktaviana, Dili; Tjong, Djong Hon; Manjas, Menkher; Gunawarman, Gunawarman
Journal of Ocean, Mechanical and Aerospace -science and engineering- Vol 51 No 1 (2018): Journal of Ocean, Mechanical and Aerospace -science and engineering- (JOMAse)
Publisher : International Society of Ocean, Mechanical and Aerospace -scientists and engineers- (ISOMAse)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36842/jomase.v51i1.42

Abstract

Utilization of an alloy titanium (particularly Ti6Al4V), as fracture fixation in biomedical application has restriction because of will associate with osseointegration failure. An effort to titanium coating by hydroxyapatite monolayer still has poor mechanical properties and may lead to implantation failure. Hydroxyapatite bilayers coating aims to protect releasing hazardous ions from implant to the body and improving the osseointegration at the same time. In this research, nanoparticle hydroxyapatite (first layers) and microparticle hydroxyapatite (second layers) were used as coating materials on implant prototype of Ti6Al4V ELI screws. The coating was carried out by electrophoretic deposition (EPD) method used different voltage (2 and 3 volt) for deposition time of 2 and 3 minutes for forming first layers. The process was then continuing for making second layer at 5 and 10 volt for 2 and 5 minutes. In order to intensify of coatings, hydroxyapatite bilayers-coated titanium was air-dried overnight and then sintered at 700oC for 1 hour. The coating layers were characterized by optical microscope, Scanning Electron Microscope (SEM) and thickness gauge series tester. Result of the study show that nanoparticle hydroxyapatite layers are more uniform, thin, dense than microparticle hydroxyapatite layer. Moreover, the second layer shows less adhesion. The obtained voltage and deposition time for best bilayers coating characteristic are 2 volt/3 minutes for nanoparticles hydroxyapatite and 5volt/5minutes for microparticles hydroxyapatite. By approximately 71%-100% surface coverage and 56µm thickness of bilayers coating, that parameters can be considered to improve osseointegration.
Co-Authors BUDI SAKSONO Djong Hon Tjong G Gunawarman, G Hanbal, Mayland Muhammad Menkher Manjas Nastiti Wijayanti Oktaviana, Dili Pratitis, Visi Endah Puspitasari, Pinki Anggrahini Tsabitah, Khansa