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All Journal Jurnal Farmasi Klinik Indonesia Jurnal Ilmu Kefarmasian Indonesia
Zazuli, Zulfan
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Impact of education on anemia in pregnant women attending Bandung community health centers: knowledge, therapy adherence, hemoglobin, and iron intake Zazuli, Zulfan; Furqani, Winda Haniva; Putri, Suci Utami Ayungga
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1559

Abstract

Anemia in pregnant women poses risks to maternal and infant health. Iron supplementation therapy (IST) adherence and adequate dietary iron intake are crucial for maintaining normal hemoglobin (Hb) levels. This study investigates the impact of education on iron deficiency anemia (IDA) knowledge, IST adherence, iron intake, and Hb levels in pregnant women. A pre-post test study was conducted at Padasuka and Pagarsih Community Health Centers in Bandung. Questionnaires measuring IDA knowledge, Brief Medication Questionnaire (BMQ) for IST adherence, and Food Frequency Questionnaire (FFQ) for iron intake were utilized. This study included a total of 88 pregnant women. The majority of the participants were aged 26-35 years (55.7%), had normal BMI values (45.4%), and exhibited normal blood pressure (60.2%). Additionally, 89.8% had no history of anemia, 90.9% had no other medical history, 92% reported having a good appetite, and 97.7% did not smoke. Education significantly improved IDA knowledge (p = 0.011), IST adherence (p = 0.006), iron intake (p = 0.001), and Hb levels (p = 0.011). Strong positive correlations were found between knowledge of IDA in pregnant women and adherence to IST (r = 0.957; p<0.001), knowledge and Fe intake (r = 0.972; p<0.001), knowledge and Hb levels (r = 0.988; p<0.001), adherence to IST and Fe intake (r = 0.933; p<0.001), adherence to IST and Hb levels (r = 0.948; p<0.001), as well as Fe intake and Hb levels (r = 0.978; p<0.001). Enhanced knowledge, IST adherence, and iron intake may mitigate anemia risks in pregnant women.
Future Prospects for Pharmacogenomics of Immune Checkpoint Inhibitors Cardiotoxicity Aryantha, Hasna Firdaus; Wisasani, Amiiratu Muthiia; Anggadiredja, Kusnandar; Zazuli, Zulfan
Indonesian Journal of Clinical Pharmacy Vol 13, No 1 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2024.13.1.34

Abstract

Immune checkpoint inhibitors (ICIs), including PD-1, PD-L1, and CTLA-4 inhibitors, have revolutionized cancer therapy but are associated with immune-related adverse events (IRAEs). Among these, ICI-associated cardiotoxicity is an uncommon yet serious complication, often resistant to glucocorticoid therapy, which effectively manages most IRAEs. A pharmacogenomic approach might be useful in prescribing ICIs and screening for relevant clinically measurable phenotypes such as the history of autoimmune diseases and cardiovascular disorders. This review explores the impact of genetic variations on ICI-associated cardiotoxicity, the mechanistic basis behind it, potential clinical applications, and directions of the future on how pharmacogenomics can assist oncologists in reducing the risk of cardiotoxicity. Evidence-based hypotheses on how ICI-associated cardiotoxicity occurs suggest that genetic differences might play a role in ICI response, especially regarding cardiotoxic IRAEs. Pharmacogenomic studies and multi-omics profiling might provide valuable insight regarding ICI-induced cardiotoxicity. They could be implemented to make fine-tuned clinical decisions for individual patients in the future.
Co-Authors Aryantha, Hasna Firdaus Furqani, Winda Haniva Kusnandar Anggadiredja Putri, Suci Utami Ayungga Wisasani, Amiiratu Muthiia