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All Journal Jurnal Farmasi Klinik Indonesia Syntax Literate: Jurnal Ilmiah Indonesia JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Ilmu Kefarmasian Indonesia
Zazuli, Zulfan
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Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Impact of education on anemia in pregnant women attending Bandung community health centers: knowledge, therapy adherence, hemoglobin, and iron intake Zazuli, Zulfan; Furqani, Winda Haniva; Putri, Suci Utami Ayungga
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 2 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i2.1559

Abstract

Anemia in pregnant women poses risks to maternal and infant health. Iron supplementation therapy (IST) adherence and adequate dietary iron intake are crucial for maintaining normal hemoglobin (Hb) levels. This study investigates the impact of education on iron deficiency anemia (IDA) knowledge, IST adherence, iron intake, and Hb levels in pregnant women. A pre-post test study was conducted at Padasuka and Pagarsih Community Health Centers in Bandung. Questionnaires measuring IDA knowledge, Brief Medication Questionnaire (BMQ) for IST adherence, and Food Frequency Questionnaire (FFQ) for iron intake were utilized. This study included a total of 88 pregnant women. The majority of the participants were aged 26-35 years (55.7%), had normal BMI values (45.4%), and exhibited normal blood pressure (60.2%). Additionally, 89.8% had no history of anemia, 90.9% had no other medical history, 92% reported having a good appetite, and 97.7% did not smoke. Education significantly improved IDA knowledge (p = 0.011), IST adherence (p = 0.006), iron intake (p = 0.001), and Hb levels (p = 0.011). Strong positive correlations were found between knowledge of IDA in pregnant women and adherence to IST (r = 0.957; p<0.001), knowledge and Fe intake (r = 0.972; p<0.001), knowledge and Hb levels (r = 0.988; p<0.001), adherence to IST and Fe intake (r = 0.933; p<0.001), adherence to IST and Hb levels (r = 0.948; p<0.001), as well as Fe intake and Hb levels (r = 0.978; p<0.001). Enhanced knowledge, IST adherence, and iron intake may mitigate anemia risks in pregnant women.
Future Prospects for Pharmacogenomics of Immune Checkpoint Inhibitors Cardiotoxicity Aryantha, Hasna Firdaus; Wisasani, Amiiratu Muthiia; Anggadiredja, Kusnandar; Zazuli, Zulfan
Indonesian Journal of Clinical Pharmacy Vol 13, No 1 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2024.13.1.34

Abstract

Immune checkpoint inhibitors (ICIs), including PD-1, PD-L1, and CTLA-4 inhibitors, have revolutionized cancer therapy but are associated with immune-related adverse events (IRAEs). Among these, ICI-associated cardiotoxicity is an uncommon yet serious complication, often resistant to glucocorticoid therapy, which effectively manages most IRAEs. A pharmacogenomic approach might be useful in prescribing ICIs and screening for relevant clinically measurable phenotypes such as the history of autoimmune diseases and cardiovascular disorders. This review explores the impact of genetic variations on ICI-associated cardiotoxicity, the mechanistic basis behind it, potential clinical applications, and directions of the future on how pharmacogenomics can assist oncologists in reducing the risk of cardiotoxicity. Evidence-based hypotheses on how ICI-associated cardiotoxicity occurs suggest that genetic differences might play a role in ICI response, especially regarding cardiotoxic IRAEs. Pharmacogenomic studies and multi-omics profiling might provide valuable insight regarding ICI-induced cardiotoxicity. They could be implemented to make fine-tuned clinical decisions for individual patients in the future.
Perceptions, Expectations, Reality, and Public Confidence Regarding the Role of Pharmacists in Pharmacy Services in Bandung Zazuli, Zulfan; Anjasmara, Aulia Putri; Amalia, Lia
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 14, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.87938

Abstract

Background: The shifting from the old paradigm to the new paradigm with the philosophy of pharmaceutical care demands pharmacists to enhance the quality of pharmaceutical services. However, this role has not been optimally fulfilled, especially in the community setting.Objectives: This study aimed to identify the perceptions and expectations, the gap between expectations and reality, and public confidence as well as to analyze the relationship between sociodemographic factors and the perceptions, expectations, and public confidence in Bandung City regarding the role of pharmacists in pharmaceutical services.Methods: A cross-sectional study was conducted using a validated survey instrument with 440 respondents in Bandung, West Java, from March to April 2023. The survey data were analyzed descriptively and through inferential statistics.Results: The analysis showed that 58.41% of the community had a positive perception, 56.82% had high expectations, the average gap between expectations and reality was 14.04%, and more than 51.36% had a high level of public confidence in pharmacists. Sociodemographic factors influencing perceptions were age and the highest level of education (p = 0.005; p = 0.003), factors influencing public confidence were age, the highest level of education, residence address according to ID card (KTP), and occupation (p < 0.001; p = 0.034; p = 0.001; p = 0.001), and the factor influencing expectations was the residence address according to ID card (KTP) (p = 0.043). A correlation was found between the dimensions of perceptions, expectations, and public confidence.Conclusion: Most participants held a positive perception, had high expectations, and shown high confidence in the pharmacist's position, despite the existence of a disparity between expectations and the actual provision of pharmacy services. The elements of perception, expectations, and confidence are interrelated.
Dampak Intervensi Edukasi dan Aplikasi Pengingat Minum Obat terhadap Pengetahuan dan Kepatuhan Pasien Tuberkulosis Paru di Puskesmas di Kota Bandung Reyaan, Irianti Bahana Maulida; Faustincia, Ivena; Zazuli, Zulfan
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.88408

Abstract

Tuberculosis (TB) patient compliance with ongoing therapy and knowledge regarding TB has an impact on the cure rate. Despite implementing various strategies, the prevalence of TB in Indonesia remains high, and the success rate of its treatment is still below the global average, potentially leading to continued transmission of TB within the community. This study aims to determine the improvement of knowledge and compliance among pulmonary TB patients following an intervention involving education and the use of a medication reminder application in two community health centers in the city of Bandung. The research design was experimental, where 29 subjects recruited were randomized into two groups: one group receiving additional education and introduction to the mobile application (Jadwal Minum Obat), and the other group receiving only counseling at the health centers. Primary data that was collected include baseline test scores and final test scores of subjects based on the KATUB-Q questionnaire. Patient compliance was assessed using the self-assessment method with the MARS-5 questionnaire and the pill count method. The subjects' experiences in the intervention group while using the mobile application were also documented. A total of 16 subjects completed the study. The education method and medication reminder application used in this study have not significantly improved the knowledge and compliance of pulmonary TB patients in taking their medication (p > 0.05). However, percentage of consumed medication compared to the prescribed medication in the intervention group higher than the control group (87.4 ± 4.8% vs 78.8 ± 8.3%). Subjects found the application useful, though there were still some shortcomings. Further research with a larger sample size using an improved medication reminder application is needed.
Analisis Kepatuhan Pengobatan Antiretroviral Tenovir-Lamivudin -Dolutegravir (TLD) di Salah Satu Puskemas di Kota Bandung Basuki, Basuki; Amalia, Lia; Zazuli, Zulfan; Rukmawati, Iis; Akromy, Muhammad Zidan Fikri
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v9i12.17132

Abstract

Kepatuhan (adherence) adalah minum obat sesuai dosis, tidak pernah lupa, tepat waktu, dan tidak pernah putus. Kepatuhan dalam meminum Antiretroviral merupakan faktor terpenting dalam menekan jumlah virus HIV dalam tubuh manusia.Kepatuhan minum obat ARV <80% merupakan suatu prediktor bagi kegagalan pengobatan HIV. WHO merekomendasikan dolutegravir sebagai terapi yang lebih dianjurkan sebagai terapi lini pertama ataupun terapi lini kedua pada pasien HIV yang sebelumnya gagal dengan pengobatan regimen tanpa dolutegravir. Penelitian ini bertujuan untuk menganalisis dan evaluasi kepatuhan pasien pengguna terapi Kombinasi Dosis Tetap (KDT) TLD di salah satu puskesmas di Kota Bandung serta faktor-faktor yang mempengaruhi kepatuhan pengobatan. Hal ini untuk meningkatkan keberhasilan terapi KDT TLD bagi pasien HIV positif di puskesmas. Jenis Penelitian ini observasional analitik dengan pendekatan menggunakan desain cross sectional. Pengumpulan data dilakukan secara retrospektif menggunakan data sekunder berupa catatan rekam medis, data Sistem Informasi HIV AIDS (SIHA) Kemenkes serta laporan pill count penggunaan obat. Dari 161 orang populasi yang memenuhi kriteria inklusi, sebanyak 143 orang (88,82%) pasien yang menggunakan terapi KDT TLD patuh dan 18 orang (11,18%) tidak patuh terhadap pengobatan ARV KDT TLD yang sedang dijalaninya. Analisis Faktor-Faktor yang mempengaruhi kepatuhan pengobatan KLD TLD dengan uji chi square dan stepwise menunjukan bahwa jenis kelamin dengan p-value = 0,000 mempunyai pengaruh yang signifikan terhadap kepatuhan pengobatan pasien, begitupun dengan usia p-value= 0,000. Hal ini menunjukan bahwa variabel jenis kelamin dan usia pasien mempengaruhi secara signifikan terhadap kepatuhan pengobatan pasien penerima terapi KDT TLD.
Co-Authors Akromy, Muhammad Zidan Fikri Anjasmara, Aulia Putri Aryantha, Hasna Firdaus Basuki , Faustincia, Ivena Furqani, Winda Haniva Kusnandar Anggadiredja LIA AMALIA Putri, Suci Utami Ayungga Reyaan, Irianti Bahana Maulida Rukmawati, Iis Wisasani, Amiiratu Muthiia