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Kusumo, M. Hidayat Budi
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Perbedaan visual analogue score (VAS) antara prosedur reseksi laparaskopik dengan laparatomi pada penderita kanker kolon Kusumo, M. Hidayat Budi; Budiono, Parish
MEDISAINS Vol 14, No 2 (2016)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v14i2.1053

Abstract

Latar Belakang: Reseksi keganasan kolorektal (KKR) dengan menggunakan pendekatan laparoskopik merupakan terobosan baru dalam bidang bedah digestif, dengan kelebihan memiliki outcome jangka pendek yang lebih baik. Tujuan : Mengetahui perbedaan visual analogue score (VAS) antara reseksi laparaskopikdan laparatomi pada keganasan kolon di RSUP dr Kariadi Semarang. periode Juli 2010 sampai dengan Desember 2013. Metode: Penelitian ini merupakan penelitian analitik observational retrospektif, dengan pendekatan cross-sectional terhadap penderita keganasan kolon yang dilakukan reseksi kolon(n=54), dengan pendekatan laparoskopik (n=23) dan laparotomi (n=31) selama periode Juli 2010 sampai dengan Desember 2013. Analisis deskriptif dan uji beda dengan Mann Whitney. Hasil: Visual analogue score (VAS) reseksi laparoskopik lebih rendah (2,83  0,650) dibandingkan laparatomi (4,13  1,565) pada penderita keganasan kolon, dan terdapat perbedaan bermakna dengan P = 0,001 (p < 0,05, CI = 95%). Kesimpulan:Pendekatan bedah laparoskopik pada keganasan kolon memberikan outcome jangka pendek yang lebih baik. Kata kunci: kanker kolon,reseksi laparoskopik, reseksi laparotomi, VAS, visual analogue score
Secretome MSCs restore α-Smooth Muscle Actin Protein Tissue Expression in Croton Oil-Induced Hemorrhoid Rats Kusumo, M. Hidayat Budi; Husain, Sofian Azalia; Amalina, Nur Dina
International Journal of Cell and Biomedical Science Vol 2 No 4 (2023)
Publisher : Stem Cell and Cancer Research (SCCR)

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Background: Hemorrhoidal disease, a prevalent and distressing condition affecting a significant number of the population, presents a considerable challenge in both clinical management and patient quality of life. Secretome mesenchymal stem cell hypoxia (S-HMSCs) is involved in accelerated remodeling and regeneration of wound tissue, including hemorrhoids, through anti-inflammatory and anti-fibrotic molecules paracrine activities. Objective: This study aims to investigate the effect of Secretome Hypoxia MSCs (S-HMSCs) in restoring α-smooth muscle actin (α-SMA) expression in croton oil-induced hemorrhoid rats. Material and Methods: An experimental study with a post-test-only control group design was used in this study. Croton oil was administrated for inducting hemorrhoidal disease. A total of 24 male Wistar rats were divided into four groups (n=6); Sham (Healthy group); Untreated (Croton oil+NaCl 300 µL) Croton oil+S-HMSCs 150); Secretome 150 µL (Croton oil+S-HM SCs 150 µL) and Secretome 300 µL (Croton oil+S-HMSCs 300 µL). S-HMSCs were injected intraperitoneally every week for up to 4 weeks. All animals were scarified and the rectal tissue was collected for α-SMA immunohistochemical staining analysis. Results: After hemorrhoid induction, α-SMA was expressed 20% higher than Sham group, furthermore, administration of 150 µL and 300 µL of S-HMSCs may decreased by 15% and 20% α-SMA expression compared to the Untreated group, expression in croton oil-induced hemorrhoid rats.
Co-Authors Amalina, Nur Dina Husain, Sofian Azalia Parish Budiono