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All Journal Jurnal Kedokteran Diponegoro MEDISAINS Bioscientia Medicina : Journal of Biomedicine and Translational Research Medica Hospitalia Jurnal Penyakit Dalam Indonesia

Parish Budiono

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Author-ID : 244454

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Articles

THE EFFECT OF ANALGESICS COMBINATION OF PARACETAMOL AND CODEINE ADMINISTRATION TO SERUM UREA IN MALE WISTAR RATS Akhiar Mar'i; Taufik Eko Nugroho; Erwin Kresnoadi; Parish Budiono
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 9, No 4 (2020): DIPONEGORO MEDICAL JOURNAL ( Jurnal Kedokteran Diponegoro )
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Background: A combination of the analgesic drug Paracetamol and Codeine can be used in moderate to severe pain management. Both are classified into two different groups of analgesics, thus they have a different mechanism of action. The combination of Paracetamol and Codeine provides better potential and work synergistically in pain management. This combination of analgesic drugs also has no potential side effects on the kidneys. Objective: To determine the combination of paracetamol and codeine analgesics on serum urea levels in male Wistar rats. Method: This study is an experimental study with a Post Test Only Control Group Design. Samples were 20 Wistar rats with certain criteria, randomly divided into 4 groups: control group, 32 mg/kgBW paracetamol group, 1,9 mg/kgBW codeine group, and 32 mg/kgBW paracetamol combination group and codeine 1,9 mg/kgBW. Giving is done orally with gastric sonde 4 times a day for 28 days. Day 29, blood is drawn through retroorbital vessels to measure serum urea levels. Statistical tests using the ANOVA and Post-Hoc tests. Results: The results obtained by the control group (32.1880), treatment group 1 (32.4240), treatment group 2 (32.3000), and treatment group 3 (31.1560). The One Way ANOVA statistical test results showed that the value of p = 0.970 (p> 0.05) which means there are no significant differences in serum urea levels between the four groups. Conclusion: There was no significant difference in the increase in the urea level between the combination of paracetamol and codeine compared to the control group.

HUBUNGAN ANTARA KADAR ALBUMIN SERUM PRAOPERASI DENGAN ILEUS PASCALAPAROTOMI PERFORASI ULKUS PEPTIKUM David Setiadarma; Parish Budiono; Ani Margawati
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 4 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Latar Belakang: Ileus pascalaparotomi perforasi ulkus peptikum merupakan ileus paralitik yang terjadi setelah dilakukannya laparotomi. Pemeriksaan kadar albumin serum praoperasi merupakan salah satu pemeriksaan yang dilakukan sebelum dilakukannya laparotomi. Diharapkan kadar albumin memiliki hubungan dengan ileus pascalaparotomi, sehingga dapat memprediksi terjadinya ileus pascalaparotomi perforasi ulkus peptikum untuk kemudian dapat dilakukan intervensi lebih lanjut untuk menurunkan komorbiditas, lama tinggal, dan biaya perawatan di rumah sakit.Tujuan: Mengetahui hubungan antara kadar albumin serum praoperasi dengan ileus pascalaparotomi perforasi ulkus peptikum melalui waktu pertama flatus, waktu pertama BAB, dan waktu pertama menerima makanan padat.Metode: Penelitian ini adalah penelitian observasional analitik prospektif dengan desain cross sectional. Sampel adalah pasien pascalaparotomi perforasi ulkus peptikum dan dirawat inap di RSUP Dr. Kariadi periode Juli 2017-Maret 2018.Hasil: Dari 25 sampel, didapatkan 18 (72%) laki-laki dan 7 (28%) perempuan dengan rerata usia 52,92±14,99 tahun. Terdapat hubungan yang berbanding terbalik secara signifikan kuat antara kadar albumin serum praoperasi dengan waktu pertama flatus (p<0,001; r=-0,715), waktu pertama BAB (p<0,001; r=-0,679), dan waktu pertama menerima makanan padat (p<0,001; r=-0,675). Didapatkan cut-off point dari kadar albumin serum praoperasi sebesar 2,95 g/dL.Kesimpulan: Terdapat hubungan antara kadar albumin serum praoperasi dengan ileus pascalaparotomi perforasi gaster.Kata Kunci: kadar albumin serum praoperasi, ileus pascalaparotomi perforasi ulkus peptikum, waktu pertama flatus, waktu pertama BAB, waktu pertama menerima makanan padat.

Antioxidant and Anti-inflammatory effect of Graptophyllum pictum (L.) Griff extract Study on SOD and COX-2 serum of experimental hemorrhoids Azhar, Abu; Riwanto, Ignatius; Nugroho, Eriawan Agung; Susilaningsih, Neni; Prajoko, Yan Wisnu; Budiono, Parish; Prasetyo, Sigit Adi
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Background The 1st, 2nd and small 3rd degree hemorrhoids are non-operatively treated by using anti-inflammatory and plebotonic medicines, high fiber diet and changing lifestyle. Graptophyllum pictum (L.) Griff (GP) is potential to be a hemorrhoid medicine (anti-inflammatory and plebotonic medicine) since its anti-inflammatory effect may be related to antioxidant property. ObjectiveTo elaborate the anti-inflammatory and anti-oxidant effect of GP on experimental hemorrhoid in male Wistar rats. MethodsA Randomized Controlled Trial Post-test only design in hemorrhoid-like rats using croton oil induced into the anus for 30 seconds each day for 3 consecutive days. 14 Wistar rats were randomly allocated into 2 groups. Group 1 got normal saline solution, while group 2 treated with GPE 100mg/Kg bw for 5 consecutive days. On the 9th experimental day, the blood was drawn for Elisa examination of COX-2 and SOD levels. As COX-2 and SOD normally distributed, pool t-test and product moment correlation was used for statistical analysis. Results All of Wistar rats were still alive. COX-2 levels (ng/ml) in the GPE group was 266.28±158.47, was significantly lower compared to control (595.21±68.92) (p=0.000). Serum SOD levels (ng/ml) in the GPE was 77.00±11.0, and was significantly higher than the control 28.00±4.00 (p=0.02). Correlation between COX-2 and SOD serum level was significantly strong negative correlation (p=0,000 and r=-0.842) Conclusions GPE at a dose of 100 mg/kg bw has antioxidant and anti-inflammatory effects on artificial hemorrhoids through decreased COX-2 levels, and elevated SOD levels. There is a strong negative correlation between SOD and COX-2 serum level. KeywordsGraptophyllum pictum, hemorrhoids, Croton oil, COX-2, SOD.

Perbedaan visual analogue score (VAS) antara prosedur reseksi laparaskopik dengan laparatomi pada penderita kanker kolon Kusumo, M. Hidayat Budi; Budiono, Parish
MEDISAINS Vol 14, No 2 (2016)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v14i2.1053

Latar Belakang: Reseksi keganasan kolorektal (KKR) dengan menggunakan pendekatan laparoskopik merupakan terobosan baru dalam bidang bedah digestif, dengan kelebihan memiliki outcome jangka pendek yang lebih baik. Tujuan : Mengetahui perbedaan visual analogue score (VAS) antara reseksi laparaskopikdan laparatomi pada keganasan kolon di RSUP dr Kariadi Semarang. periode Juli 2010 sampai dengan Desember 2013. Metode: Penelitian ini merupakan penelitian analitik observational retrospektif, dengan pendekatan cross-sectional terhadap penderita keganasan kolon yang dilakukan reseksi kolon(n=54), dengan pendekatan laparoskopik (n=23) dan laparotomi (n=31) selama periode Juli 2010 sampai dengan Desember 2013. Analisis deskriptif dan uji beda dengan Mann Whitney. Hasil: Visual analogue score (VAS) reseksi laparoskopik lebih rendah (2,83  0,650) dibandingkan laparatomi (4,13  1,565) pada penderita keganasan kolon, dan terdapat perbedaan bermakna dengan P = 0,001 (p < 0,05, CI = 95%). Kesimpulan:Pendekatan bedah laparoskopik pada keganasan kolon memberikan outcome jangka pendek yang lebih baik. Kata kunci: kanker kolon,reseksi laparoskopik, reseksi laparotomi, VAS, visual analogue score

Ozonated Aloe Vera: A Novel Topical Agent for Improved Wound Healing and Reduced Scar Formation on TGF-β Modulation Invivo Study Ahsanu Taqwim Hidayat; Parish Budiono
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 1 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i1.1159

Background: Chronic wounds and impaired wound healing represent a significant healthcare burden. Aloe vera has been recognized for its therapeutic potential in wound healing, and the combination with ozone, and ozonated aloe vera, may offer synergistic effects. This study investigated the effects of ozonated aloe vera oil on wound healing and scar formation, focusing on TGF-β modulation in a rat model. Methods: Full-thickness skin defects were created on 50 Sprague Dawley rats, which were randomly divided into five groups: (1) control (untreated), (2) aloe vera oil, (3) ozonated aloe vera oil (600 mg/ml ozone), (4) ozonated aloe vera oil (1200 mg/ml ozone), and (5) ozonated aloe vera oil (1800 mg/ml ozone). Wound healing was assessed macroscopically by measuring wound area reduction and microscopically by evaluating TGF-β expression through immunohistochemical staining on days 3, 7, and 14. Results: Ozonated aloe vera oil significantly accelerated wound healing compared to the control and aloe vera oil alone groups (p < 0.05). The highest ozone concentration (1800 mg/ml) showed the most rapid wound closure and the lowest TGF-β expression on day 14 (p < 0.05). Histological analysis revealed enhanced collagen organization and reduced inflammatory cell infiltration in ozonated aloe vera oil treated wounds. Conclusion: Ozonated aloe vera oil effectively promotes wound healing and reduces scar formation in a rat model. The modulation of TGF-β signaling plays a crucial role in these effects. Ozonated aloe vera oil holds promise as a novel topical agent for improved wound management.

Status Gizi sebagai Faktor Risiko Mortalitas di Rumah Sakit pada Pasien Lanjut Usia Pasca Reseksi Tumor Kolorektal Wulandari, Ayu Fitri Sekar; Budiono, Parish; Mupangati, Yudo Murti
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Introduction. Malnutrition in elderly patients, particularly those with colorectal cancer, increases morbidity, mortality, and length of hospital stay due to metabolic dysregulation and hypermetabolic perioperative response, affecting wound healing, infection risk, postoperative complications, and nutritional deficits. This study aimed to analyze whether nutritional status is a risk factor for in-hospital mortality in elderly patients after colorectal tumor resection. Methods. A case-control matching study was conducted on elderly patients who underwent colorectal tumor resection, using secondary data from elderly inpatients at Dr. Kariadi General Hospital from January 2020 to April 2024. The collected data were analyzed using bivariate analysis with the Chi-square test and multivariate analysis with logistic regression. Results. The study involved 48 elderly patients who died during treatment and 48 elderly patients who survived until the end of treatment. Nutritional screening assessed with Skrining Gizi Kariadi (SGK) was not associated with in-hospital mortality after colorectal tumor resection [p=0.306; OR 1.952 (95% CI 0.694-5.491)]. However, nutritional assessment based on American Society for Parenteral and Enteral Nutrition (ASPEN) criteria was associated with in-hospital mortality after colorectal tumor resection [p<0.001; OR 5.800 (95% CI 2.345-14.344)]. The results of the multivariate analysis also revealed a significant link between nutritional status based on the ASPEN criteria (p=0.028) and a higher risk of in-hospital mortality in elderly patients after colorectal tumor resection. Conclusion. Nutritional status, based on ASPEN criteria, is a risk factor for in-hospital mortality in elderly patients after colorectal tumor resection.

Co-Authors Ahsanu Taqwim Hidayat Akhiar Mar'i Ani Margawati Azhar, Abu David Setiadarma Eriawan Agung Nugroho, Eriawan Agung Erwin Kresnoadi Ignatius Riwanto, Ignatius Kusumo, M. Hidayat Budi Kusumo, M. Hidayat Budi Mupangati, Yudo Murti Neni Susilaningsih Sigit Adi Prasetyo, Sigit Adi Taufik Eko Nugroho Wulandari, Ayu Fitri Sekar Yan Wisnu Prajoko

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