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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Indonesian Journal of Biotechnology JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasetis Acta Holistica Pharmaciana
Arimurni, Dewa Ayu
Sekolah Tinggi Farmasi Mahaganesha
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Other

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Journal : JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA

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Formulation and Characterization of Carbamazepine Chitosan Nanoparticle Citra Ariani Edityaningrum; Ariza Nur Zulaechah; Widyasari Putranti; Dewa Ayu Arimurni
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 2 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i22022.146-154

Abstract

Background: Carbamazepine is an antiepileptic drug used to treat trigeminal neuralgia and pain associated with neurological disorders. The drug belongs to class II of the Biopharmaceutical Classification System (BCS), which has low solubility. Hence, dissolution is a rate-limiting step. Objective: This study aimed to determine the best formula for carbamazepine nanoparticles based on physical characteristics and determine the effect of chitosan and Na-TPP concentration variation on nanoparticle characterization. Methods: The carbamazepine chitosan nanoparticles were prepared using ionic gelation method with a concentration of 0.1% w/v carbamazepine and the ratio of chitosan and Na-TPP concentrations of 0.2%:0.1% (F1), 0.2%:0.2% (F2), and 0.3%:0.1% w/v (F3). The parameters evaluated included particle size, polydispersity index, zeta potential, particle morphology, and entrapment efficiency. Statistical analysis was conducted on the evaluation data using One Way ANOVA. Results: The results showed that the effect of increasing the concentration of chitosan reduced particle size (p<0.05), increased zeta potential (p<0.05), and had no effect on the value of entrapment efficiency (p>0.05). Furthermore, F3 had a particle size of 169.8±13.71 nm with a polydispersity index of 0.378±0.02, the zeta potential of +28.80±2.44 mV, entrapment efficiency of 84.3±7.50%, and spheric particle morphology which was measured using Transmission Electron Microscope (TEM). Conclusion: Therefore, F3 with the ratio of chitosan and Na-TPP concentrations of 0.3%:0.1% was the formula that provided the best characteristics of chitosan carbamazepine nanoparticles.
Formulations and Antibacterial Activity of Shallot (Allium cepa L.) Peel Extract Patch against Streptococcus pyogenes Azizah, Siwi Nur; Ste, Luay Banna; Maulida, Khansa Syahira; Zahirah, Nadrah Adinda; Nisa, Salsabila Naura; Sri Mulyaningsih; Arimurni, Dewa Ayu; Edityaningrum, Citra Ariani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 2 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i22025.247-255

Abstract

Background: Bacterial pharyngitis is an inflammatory condition in the back of the throat caused by Streptococcus pyogenes. Patients are often prescribed antibiotics and antiinflammatories to alleviate pain and discomfort while reducing bacterial growth in the throat. However improper and prolonged use of antibacterial and antiinflammatory agents increases the risk of bacterial resistance and side effects. An often discarded Shallot (Allium cepa L.) peel rich in flavonoids with great antibacterial and anti-inflammatory properties is potentially used as an alternative treatment for bacterial pharyngitis. Objective: This study aimed to develop shallot peel extract as an antibacterial against Streptococcus pyogenes. Methods: Patch was formulated with variations in extract concentration of 5% (F1), 10% (F2), and 15% (F3) to observe their influence on weight uniformity, thickness, folding endurance, surface pH, moisture content, and antibacterial activity using disc diffusion. Results: All formulations produce slightly heavy and thicker but uniform patches (CV<5%), surface pH suitable for application in the skin (4.6-4.9), flexible and durable patches with high folding endurance (> 300 folds), good moisture content (<10%) and moderate to strong antibacterial activity (inhibition zone diameter ranging from 9 to 13.67 mm). Variations in extract concentration in the formula significantly influenced the thickness, weight, folding endurance, and also the antibacterial activity of the patches. Higher concentrations of extract produce thicker and heavier patches but stronger antibacterial activity against pharyngitis pathogens. Conclusion: Therefore, antibacterial patches containing up to 15% shallot peel extract are potentially used as an alternative treatment for pharyngitis.
Co-Authors Anggun Feranisa Ariza Nur Zulaechah Artika Tri Oktafiani Azizah, Siwi Nur Citra Ariani Edityaningrum, Citra Elisabeth Oriana Jawa La Erika Yuda Colatama Gede Ngurah Ary Zega Widyartha Gracia Isabel Baptista Soares Hilda Ismail, Hilda Komang Angelita Safira Luh Gede Tina Sujayanti Made Dwi Pradipta Wahyudi S Maulida, Khansa Syahira Ni Komang Eni Astari Ni Putu Ratna Mulia Adnyani Nisa, Salsabila Naura Putu Bisma Duta Valenrika Ricardo, I Komang Aan Adi Ronny Martien S. Sismindari Sri Mulyaningsih Ste, Luay Banna Widiyastuti, Lina Widyasari Putranti Zahirah, Nadrah Adinda