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STUDI KELARUTAN PROPAGERMANIUM DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI Putranti, Widyasari; Martodihardjo, Suwaldi; Lukitaningsih, Endang
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Propagermanium, a synthetic organic compound of germanium is known as Î²- or biscarboxyethylgermaniumsesquioxide or Ge-132. It is found in some plants such as shelf fungus,ginseng, garlic, and Aloe vera. Ge-132 plays an important role for the pharmacological effectsof the plants. The solubility of propagermanium at a certain pH is not exactly known yet. Untilnow, the analytical methods for the analysis of Ge-132 so far have the shortcoming and thepropagermanium as germanium metal in the sample, so that improvement for propagermaniumanalysis was necessary to be conducted, primarily to be used for solubility assay. This studyaims to determine the effects of pH on the propagermanium solubility using HPLC method foranalysis. The results showed that validation parameters for analysis by using HPLC method e.iaccuracy, precision, and linearity, have met to the quantitative analysis requirements. Increasingthe pH causes increasing the solubility of propagermanium in the pH range of 3.0-3.6. Thesolubility result was 9.8514; 10.4204; 12.5446 mg/mL on pH 3.0; 3.3; 3.6.

PENGARUH PERBEDAAN KONSENTRASI HCl DAN WAKTU DEMINERALISASI TERHADAP SIFAT FISIK GEL GELATIN TULANG CEKER AYAM Choirunnisa, Fina; Putranti, Widyasari
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 3, No 2 (2018)
Publisher : Akademi Farmasi ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (8.262 KB)

Uji pengaruh perbedaan konsentrasi HCl dan waktu demineralisasi terhadap sifat fisik gel gelatin tulang ceker ayam dilakukan untuk melihat ada tidaknya pengaruh perbedaan konsentrasi HCl yang digunakan sebagai katalis dan waktu demineralisasi terhadap rendemen, pH, viskositas, kadar air, dan kadar abu gelatin tulang ceker ayam yang dihasilkan. Penelitian ini menggunakan rancangan acak lengkap (RAL) dengan dua faktor yaitu variasi konsentrasi HCl (0,05 N, 0,15 N dan 0,2 5N) dan variasi waktu demineralisasi (12 jam dan 24 jam). Gel gelatin tulang ceker ayam diperoleh dengan proses hidrolisa tulang ceker ayam yang sudah didemineralisasi dengan larutan asam. Hasil dari hidrolisa tersebut dikeringkan untuk menghasilkan gelatin kering yang akan dilakukan pengujian sifat fisiknya. Hasil penelitian ini menunjukkan perbedaan konsentrasi HCl dan waktu demineralisasi berpengaruh terhadap rendemen, viskositas, dan kadar air gelatin yang dihasilkan. Perbedaan konsentrasi HCl dan waktu demineralisasi tidak berpengaruh terhadap pH dan kadar abu gelatin yang dihasilkan.

OPTIMALISASI PEMANFAATAN JAHE (ZINGIBER OFFICINALE) DAN ROSELLA (HIBISCUS SABDARIFA) SEBAGAI MINUMAN KESEHATAN DI MADRASAH MUALLIMIN MUHAMMADIYAH YOGYAKARTA Saputri, Ginanjar Zukhruf; Dania, Haafizah; Putranti, Widyasari
Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Vol 2, No 2 (2018)
Publisher : Universitas Ahmad Dahlan, Yogyakarta

Sekolah berbasis asrama memiliki beberapa permaslahan terutama di bidang kesehatan. Hasil survey dan skrining kesehatan yang telah dilakukan menunjukkan tingginya prevalensi penyakit menular seperti flu, batuk pilek (16.5%) dan penyakit kulit seperti jamur, gatal, scabies (11.2%). Adanya pos kesehatan pesantren di lingkungan sekolah tersebut diharapkan dapat mengoptimalkan promosi kesehatan dalam upaya pencegahan penyakit. Hal tersebut didukung pula dengan optimalisasi pemanfaatan TOGA (tanaman obat keluarga) yang ada di setiap asrama sekolah. Lahan yang cukup luas dan tempat tinggal (asrama) siswa yang terpisah menjadi peluang dalam pengembangan penanaman TOGA, di dukung dengan pemanfaatan TOGA dalam bentuk sediaan minuman kesehatan dirasa lebih menarik dan penting untuk diupayakan sebagai salah satu kegiatan edukasi dan promosi kesehatan di lingkungan sekolah berasis asrama. Kegiatan pemberdayaan masyarakat ini bertujuan untuk melakukan pendampingan pemanfaatan TOGA dan pelatihan pemanfaatan tanaman Jahe (Zingiber officinale) dan tanaman rosella (Hibiscus sabdarifa) sebagai minuman kesehatan (syrup). Kegiatan ini meliputi dua sesi, yaitu sosialisasi hasil skrining kesehatan siswa dan edukasi kesehatan diri “swamedikasi” yang diikuti oleh pengelola madrasah, staf poskestren (perawat dan dokter), serta ibu pamong asrama (ummahat). Adapun kegiatan kedua adalah pelatihan pemanfaatan TOGA Jahe (Zingiber officinale) dan Rosella (Hibiscus sabdarifa) sebagai minuman kesehatan yang diikuti oleh 44 siswa Madrasah Mu’allimin Muhammadiyah Yogyakarta. Pengetahuan siswa sebelum dan sesudah pelatihan menunjukkan peningkatan skor rerata dari 5.56 menjadi 9.18 dengan nilai signifikansi P=0.000 (P<0.05). Hal ini menunjukkan bahwa pelatihan ini efektif dan dapat meingkatkan pengetahuan siswa Madrasah Mu’allimin Muhammadiyah Yogyakarta. Melalui pelatihan ini diharapkan siswa mampu mengaplikasikan terutama saat progam Mubaligh Hijrah yang menjadi salah satu program rutin Madrasah dalam praktek di masyarakat sekitar. Kegiatan ini diharapkan pula dapat ditindak lanjuti oleh poskestren untuk bersinergi dengan ibu pamong ataupun kantin untuk dapat mengoptimalkan TOGA di lingkungan asrama dan memulai produksi sediaan syrup kesehatan Jahe dan Rosella.

STANDARDIZATION OF EXTRACT AND CHARACTERIZATION OF EMULGEL FORMULA OF LENGKUAS (Alpinia galanga (L.) Willd) RHIZOME EXTRACT Widyasari Putranti; Novia Ariani Dewi; Lina Widiyastuti
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 15, No 2 (2018)
Publisher : Sanata Dharma University

The lengkuas rhizome has an antifungal activity. The non-specific parameters for extracts of lengkuas rhizome need to be standardized to obtain the extracts with consistent good quality. The lengkuas rhizome extract emulgel topical preparations are easily mixed with active substances that are hydrophobic or hydrophilic. This study aims to obtain a lengkuas rhizome extract emulgel formula that has good quality and good physical properties. Extraction of lengkuas rhizome was obtained using a maceration method with 96% ethanol solvent. The extract is standardized by non-specific parameters. After that, the extract was formulated in the form of emulgel preparation with 10% concentration. The physical properties of emulgel were evaluated. The results of the study showed that the extract yield is of (14.660.056)%; powder drying shrinkage (8.630.134)%; extract water rate (50)%; powder total ash rate (3.240.017)%; and extract (1.300.035)%; acid-insoluble ash rate powder (2.660.10)%; and extract (0.870.031)%; extract type weight 1.01; and the physical properties of emulgel preparations were homogeneous emulgel, semisolid form, light brown color, distinctive smell of lengkuas rhizome extract, stable at 5oC and 25oC for 24 hours; pH 7; spreadability (2.450.03) g.cm.s-1; stickiness (8.800.72) seconds; o/w emulsion type; and viscosity (1.370.22) Pa.s. This study obtained extracts of lengkuas rhizomes that meet the requirements of non-specific parameter standardization in general and the formulation of lengkuas rhizome extract emulgel had good physical properties.

STUDI KELARUTAN PROPAGERMANIUM DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI Widyasari Putranti; Suwaldi Martodihardjo; Endang Lukitaningsih
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Propagermanium, a synthetic organic compound of germanium is known as Î²- or biscarboxyethylgermaniumsesquioxide or Ge-132. It is found in some plants such as shelf fungus,ginseng, garlic, and Aloe vera. Ge-132 plays an important role for the pharmacological effectsof the plants. The solubility of propagermanium at a certain pH is not exactly known yet. Untilnow, the analytical methods for the analysis of Ge-132 so far have the shortcoming and thepropagermanium as germanium metal in the sample, so that improvement for propagermaniumanalysis was necessary to be conducted, primarily to be used for solubility assay. This studyaims to determine the effects of pH on the propagermanium solubility using HPLC method foranalysis. The results showed that validation parameters for analysis by using HPLC method e.iaccuracy, precision, and linearity, have met to the quantitative analysis requirements. Increasingthe pH causes increasing the solubility of propagermanium in the pH range of 3.0-3.6. Thesolubility result was 9.8514; 10.4204; 12.5446 mg/mL on pH 3.0; 3.3; 3.6.

Enhancing the dissolution rate of mefenamic acid with solid dispersion system using avicel PH-101 Widyasari Putranti; Lina Widiyastuti; Fitri Ulfani
Pharmaciana Vol 9, No 1 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Â Mefenamic acid, based on the Biopharmaceutics Classification System (BCS), is a class II drug that has high permeability but low water solubility. To improve its intrinsic dissolution rate, it is usually combined with a hydrophilic and porous drug carrier like Avicel to create a solid dispersion. This study aimed to enhance the intrinsic dissolution rate of mefenamic acid using a solid dispersion with Avicel PH-101. The test of intrinsic dissolution rate involved a rotational speed of 60 rpm and CO2-free water with a temperature of 37Â°C as a medium. The interaction of mefenamic acid and Avicel PH-101 was analyzed with FTIR and DSC spectroscopy. The test results showed that the intrinsic dissolution rates (in mg.cm-2.minute-1) of three replications of mefenamic acid, Solid Dispersion of Mefenamic Acid and Avicel PH-101 (SDMA) with 1:1 ratio, SDMA with 1:2 ratio, Physical Mixture of Mefenamic Acid and Avicel PH-101 (PMMA) with 1:1 ratio, and PMMA with 1:2 ratio were (8.0x10-4 Â± 3.0x10-4), (38.0x10-4 Â± 3.0x10-4), (67.0x10-4 Â± 10.0x10-4), (20.0x10-4 Â± 6.0x10-4), and (44.0x10-4 Â± 14.0x10-4), respectively. The interaction between mefenamic acid and Avicel PH-101 created a hydrogen bonding, as evidenced by the shift in the peaks of FTIR spectra. Based on the DSC thermogram, the mefenamic acid-Avicel PH-101 interaction shifted the steep peak on the curve of mefenamic acid slightly. Avicel PH-101 in this solid dispersion can increase the intrinsic dissolution rate of mefenamic acid through hydrogen bonding instead of decreasing its crystalline structure into an amorphous from.

Toxicity Study of Volatile Oil Boesenbergia pandurata (Roxb) Schlecht Rhizome to Larvacide of Aedes aegypti and GC-MS Profile Widyasari Putranti; Saiful Bachri
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Boesenbergia pandurata (Roxb) Schlecht has been recognized by society as traditional drug for a long time. The active constituent of this plants especially the volatile oil, which contains monoterpenes and sesquiterpenes. The use of Boesenbergia pandurata (Roxb) Schlecht rhizome which is a botanical insecticide shows higher safety because the molecule is easily broken down into harmless compounds against the environment. The aim of this research were to know about the activity of larvacide from the volatile oil of Boesenbergia pandurata (Roxb) Schlecht rhizome and also to analyze its chemical compounds using GC-MS. The volatile oil was isolated from Boesenbergia pandurata (Roxb) Schlecht with steam and water destillation method. The volatile oil in the aqueous ethanol 70 % v/v was made as the test solution for larvacide. The concentrations of the volatile oil of Boesenbergia pandurata (Roxb) Schlecht rhizomes used were 150 ppm; 201 ppm; 270 ppm; 362 ppm; 485 ppm; 650 ppm. Abate was used as positive control at concentration 0,001 ppm; 0,0025 ppm; 0,0065 ppm; 0,016 ppm; 0,04 ppm; 0,1 ppm while aqueous ethanol 70 % v/v was used as negative control. Each treatment were used 20 larvaes of Aedes aegypti and was observed during 24 hours. The data of died larvae were counted to estimate the values of LC50 with probit analysis method. The chemical compound of volatile oil of Boesenbergia pandurata (Roxb) Schlecht was analyzed by the GC-MS. The results of this research showed that the volatile oil of Boesenbergia pandurata (Roxb) Schlecht have clear-brass colour, bitter taste, typically aromatic, rendemen equal to (0,25 ± 0,011) % v/w and refractive index 1,4818. The value of LC50 for the volatile oil of Boesenbergia pandurata (Roxb) Schlecht rhizome is (407,06 ± 31,6985) ppm while abate equal to (0,0132 ± 0,0013) ppm. This matter indicates that abate more potent to larvae of Aedes aegypti. The result of analyze the component of the volatile oil of Boesenbergia pandurata (Roxb) Schlecht by the GC-MS obtained of 15 peak chromatogram and 6 peak which has identified showed the possibility the existence of champene, eucalyptol, ocimene, camphora, geraniol, methyl cinnamate.

Formulation and Antifungal Activity of Piper betle L. Leaf Extract in Emulsion Gels Against Candida albicans Widyasari Putranti; Chairisty Asterina; Hardi Astuti Witasari
Majalah Obat Tradisional Vol 26, No 1 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.53257

Candidiasis is the most common fungal infection in humans and is a form of primary and secondary infections of C. albicans. Betel (Piper betle L.) leaf extract has been reported to exhibit efficacious antifungal effects against C. albicans. Emulsion gels, a type of topical dosage form, can deliver hydrophilic and hydrophobic drugs and perform multiple and controlled releases. This research aimed to determine the antifungal activity and physical properties of emulsion gels formulated from betel leaf extract. The dried betel leaves were extracted by maceration with alcohol 95%. Then, with different concentrations (1, 2, and 4%), the extract was formulated into emulsion gels. These dosage forms were later subjected to antifungal activity testing against C. albicans using the cup plate diffusion method that involved Mycoral Cream® for comparison. In this test, the intensity of the activity was determined by measuring the diameter of the formed inhibition zone. The second test evaluated the physical characteristics of the dosage forms, including organoleptic properties, pH, adhesion, dispersion, and viscosity. These data were analyzed using the Mann-Whitney method, and the conclusion was withdrawn from describing the results quantitatively. The reaction yield of the extraction was 9.702%. The analysis results showed that emulsion gels containing 1, 2, and 4% of betel leaf extract created zones of inhibition with diameters of 5.3 ± 0.29, 6.2 ± 0.29, and 10.2 ± 0.41 mm, respectively. As for the physical properties, they differed in pH (6.39 ± 0.120, 6.17 ± 0.132, 5.66 ± 0.123), spreadability (1.849 ± 0.45, 1.816 ± 0.051, 1.771 ± 0.092 g.cm.s-1), adhesion (110 ± 10.8, 126.3 ± 8.5, 142.7 ± 13.50 seconds), and viscosity (2640.35, 1992.95, 2162.12 cps), respectively. The betel leaf emulsion gels exhibited antifungal activity against C. albicans (p <0.05) and met the physical requirements of semi-solid dosage forms.

OPTIMALISASI PEMANFAATAN JAHE (ZINGIBER OFFICINALE) DAN ROSELLA (HIBISCUS SABDARIFA) SEBAGAI MINUMAN KESEHATAN DI MADRASAH MUALLIMIN MUHAMMADIYAH YOGYAKARTA Ginanjar Zukhruf Saputri; Haafizah Dania; Widyasari Putranti
Jurnal Pemberdayaan: Publikasi Hasil Pengabdian Kepada Masyarakat Vol. 2 No. 2 (2018)
Publisher : Universitas Ahmad Dahlan, Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jp.v2i2.383

Sekolah berbasis asrama memiliki beberapa permaslahan terutama di bidang kesehatan. Hasil survey dan skrining kesehatan yang telah dilakukan menunjukkan tingginya prevalensi penyakit menular seperti flu, batuk pilek (16.5%) dan penyakit kulit seperti jamur, gatal, scabies (11.2%). Adanya pos kesehatan pesantren di lingkungan sekolah tersebut diharapkan dapat mengoptimalkan promosi kesehatan dalam upaya pencegahan penyakit. Hal tersebut didukung pula dengan optimalisasi pemanfaatan TOGA (tanaman obat keluarga) yang ada di setiap asrama sekolah. Lahan yang cukup luas dan tempat tinggal (asrama) siswa yang terpisah menjadi peluang dalam pengembangan penanaman TOGA, di dukung dengan pemanfaatan TOGA dalam bentuk sediaan minuman kesehatan dirasa lebih menarik dan penting untuk diupayakan sebagai salah satu kegiatan edukasi dan promosi kesehatan di lingkungan sekolah berasis asrama. Kegiatan pemberdayaan masyarakat ini bertujuan untuk melakukan pendampingan pemanfaatan TOGA dan pelatihan pemanfaatan tanaman Jahe (Zingiber officinale) dan tanaman rosella (Hibiscus sabdarifa) sebagai minuman kesehatan (syrup). Kegiatan ini meliputi dua sesi, yaitu sosialisasi hasil skrining kesehatan siswa dan edukasi kesehatan diri â€œswamedikasiâ€ yang diikuti oleh pengelola madrasah, staf poskestren (perawat dan dokter), serta ibu pamong asrama (ummahat). Adapun kegiatan kedua adalah pelatihan pemanfaatan TOGA Â Jahe (Zingiber officinale) dan Rosella (Hibiscus sabdarifa) sebagai minuman kesehatan yang diikuti oleh 44 siswa Madrasah Muâ€™allimin Muhammadiyah Yogyakarta. Pengetahuan siswa sebelum dan sesudah pelatihan menunjukkan peningkatan skor rerata dari 5.56 menjadi 9.18 dengan nilai signifikansi P=0.000 (P<0.05). Hal ini menunjukkan bahwa pelatihan ini efektif dan dapat meingkatkan pengetahuan siswa Madrasah Muâ€™allimin Muhammadiyah Yogyakarta. Melalui pelatihan ini diharapkan siswa mampu mengaplikasikan terutama saat progam Mubaligh Hijrah yang menjadi salah satu program rutin Madrasah dalam praktek di masyarakat sekitar. Kegiatan ini diharapkan pula dapat ditindak lanjuti oleh poskestren untuk bersinergi dengan ibu pamong ataupun kantin untuk dapat mengoptimalkan TOGA di lingkungan asrama dan memulai produksi sediaan syrup kesehatan Jahe dan Rosella.

PENGARUH PERBEDAAN KONSENTRASI HCl DAN WAKTU DEMINERALISASI TERHADAP SIFAT FISIK GEL GELATIN TULANG CEKER AYAM Fina Choirunnisa; Widyasari Putranti
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 3 No 2 (2018): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Uji pengaruh perbedaan konsentrasi HCl dan waktu demineralisasi terhadap sifat fisik gel gelatin tulang ceker ayam dilakukan untuk melihat ada tidaknya pengaruh perbedaan konsentrasi HCl yang digunakan sebagai katalis dan waktu demineralisasi terhadap rendemen, pH, viskositas, kadar air, dan kadar abu gelatin tulang ceker ayam yang dihasilkan. Penelitian ini menggunakan rancangan acak lengkap (RAL) dengan dua faktor yaitu variasi konsentrasi HCl (0,05 N, 0,15 N dan 0,2 5N) dan variasi waktu demineralisasi (12 jam dan 24 jam). Gel gelatin tulang ceker ayam diperoleh dengan proses hidrolisa tulang ceker ayam yang sudah didemineralisasi dengan larutan asam. Hasil dari hidrolisa tersebut dikeringkan untuk menghasilkan gelatin kering yang akan dilakukan pengujian sifat fisiknya. Hasil penelitian ini menunjukkan perbedaan konsentrasi HCl dan waktu demineralisasi berpengaruh terhadap rendemen, viskositas, dan kadar air gelatin yang dihasilkan. Perbedaan konsentrasi HCl dan waktu demineralisasi tidak berpengaruh terhadap pH dan kadar abu gelatin yang dihasilkan.

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