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All Journal Sainstech Farma: Jurnal Ilmu Kefarmasian The Health Researchers Journal
Wahyuningtyas, Wahyuningtyas
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Tyrosinase Enzyme Inhibition Activity Test by Ethanol Extract of Taro Leaf (Typhonium flagelliforme (Lodd.) Blume) In Vitro Sholikha, Munawarohthus; Wahyuningtyas, Wahyuningtyas; Puspitasari, Lia
Sainstech Farma: Jurnal Ilmu Kefarmasian Vol 16 No 1 (2023): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : LPPM, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v16i1.1451

Abstract

Hyperpigmentation is an event that occurs due to excessive production of skin pigment. Skin color is strongly influenced by the presence of melanin, where the presence of melanin is strongly influenced by the enzyme tyrosinase. Taro leaf (Typhonium flagelliforme (Lodd.) Blume) are one of the plants have flavonoid compounds used as antioxidants and tyrosinase inhibitors. The aim of this study was to test the ethanol extract of taro leaf as a tyrosinase inhibitor. Taro leaf in this study were obtained through an extraction process using 96% ethanol solvent by maceration method. The thick ethanol extract of taro leaf was tested for phytochemical screening, total flavonoid levels, and tyrosinase inhibition test. The method used for tyrosinase inhibition test was enzymatic method in vitro. The results of this study indicated that there was a total flavonoid compound content of 0.7378% (b/b) and the inhibitor activity can be seen from the IC50 value for the diphenolation reaction (L-DOPA substrate) which was 13.307 mg/mL. This value was greater when compared with 0.093 mg/mL of phenolic acid, so that the ethanol extract of taro leaf has the potential to inhibit tyrosinase activity.
Pengaruh Faktor Pekerjaan  Terhadap  Tingkat  Risiko Musculoskeletal Disorders (MSDs) Pada Tenaga Kerja di Sektor Pendidikan Handoko, Lukman; Natsir Amrullah, Haidar; wahyuningtyas, wahyuningtyas
The Health Researcher's Journal Vol. 1 No. 01 (2024): The Health Researchers Journal
Publisher : The SDGS Forum Communication

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Abstract

Musculoskeletal disorders (MSDs) are a musculoskeletal disorder characterized by an injury to the muscles, tendons, ligaments, nerves, joints, cartilage, bones or blood vessels of the hands, feet, head, neck or back. MSDs can be caused or exacerbated by work, work environment and work performance. Musculoskeletal Disorders (MSDs) are one of the most common occupational diseases, ranking second among all cases of occupational diseases, in Indonesia the prevalence of musculoskeletal problems is 7.3%. The purpose of this study is to determine the contributing factors to the development of musculoskeletal disorders (MSDs) among employees in the education sector. A cross-sectional design was employed as the research methodology, and the sample size consisted of fifty education sector employees. Direct observation, in-person interviews using questionnaires, as well as taking pictures and videos of the work, were the methods used to collect data. Binary logistic regression was used for data analysis in order to ascertain the association between MSDs and work-related variables such as manual lifting, repetitive motions, and body position. The findings of the study indicated that 48% of participants complained of MSDs in the upper body, and most employees had bad posture. The results of the binary logistic regression test indicate a significant
Co-Authors Lia Puspitasari Lukman Handoko Munawarohthus Sholikha Natsir Amrullah, Haidar