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All Journal Jurnal Kedokteran Hewan Jurnal Penyakit Dalam Indonesia
Murzalina, Cut
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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Karakteristik Pasien Rinitis Alergi dengan Hasil Uji Cukit Kulit Positif yang Berobat di Poliklinik THT-KL Rumah Sakit Umum Daerah Zainoel Abidin Banda Aceh T.R, T. Husni; Murzalina, Cut; Elvia, Elvia; Alia, Dina; Razali, Rezania; Annisa, Siti Nur; Putra, Teuku Romi Imansyah; Farhana, Rika
Jurnal Penyakit Dalam Indonesia Vol. 11, No. 2
Publisher : UI Scholars Hub

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Abstract

Introduction. Allergic rhinitis is an inflammatory disease mediated by IgE in the nasal mucosa, resulting from allergen sensitization and causing various clinical symptoms. The skin prick test is the primary diagnostic technique used to detect specific IgE antibodies against allergenic proteins and peptides. The incidence of allergic rhinitis in Indonesia ranges from approximately 1.5% to 12.4% and increases every year. This study aims to determine the characteristics of allergic rhinitis sufferers with positive skin prick test results who received treatment at the ENT outpatient service of Zainoel Abidin Regional General Hospital (RSUDZA) Banda Aceh from January 2019 to March 2020. Methods. This was a retrospective descriptive study with a cross-sectional design that utilized secondary data from patient medical records. The samples were collected using the total sampling technique, encompassing a total of 62 patients in this study. Results. This study revealed that allergic rhinitis sufferers with positive skin prick test results were predominantly in the age group 17-25 years (27.4%), female (69.4%), and from Banda Aceh (56.5%). Most of the rhinitis patients were students (41.9%), with the highest level of education being high school (43.5%). Allergic rhinitis is frequently caused by house dust mites (24.2%) as inhalant allergens and shrimp (26.3%) as ingested allergens. Most allergic rhinitis patients who visited complained most frequently of sneezing more than five times (26.3%). Conclusions. This study concluded that the characteristics of allergic rhinitis sufferers with positive skin prick test results in RSUDZA are predominantly in the late adolescent age group (17-25 years), female, with house dust mites and shrimp as the main allergens, and the most common clinical symptom is sneezing more than 5 times.
ANTICANCER ACTIVITY OF ETHANOL EXTRACT OF YELLOW ROOT (Arcangelisia flava) ON HEPG2 HEPATOCELLULAR CANCER CELLS Yusuf, Hanifah; Fahriani, Marhami; Murzalina, Cut
Jurnal Kedokteran Hewan Vol 16, No 1 (2022): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v16i1.23615

Abstract

This study aimed to evaluate anticancer activity and apoptosis induction of ethanolic extract of Arcalengisia flava (AF) roots on HepG2 cancer cell lines. The AF roots were extracted by maceration using ethanol 80%. MTT assay method was used to evaluate the anticancer activity and the proliferation of HepG2 cells. Flow cytometry method was used to assess the induction of HepG2 cells apoptosis. This study showed that the IC50 of AF ethanol extract against HepG2 cells was 109.14 g/ml. With IC50 treatment, the apoptosis assay showed a significant decrease in intact cells (80.101.7%) and a significant increase in early apoptosis (7.90.7%) and late apoptosis cells of HepG2 cancer cells (4.90.35%) compared to control cells. Moreover, the proliferation of HepG2 cells was declined significantly in 48 and 72 hours after treatment with IC50 (77.55.76% and 64.35.37%, respectively) and 2xIC50 of the extract (75.91.79% and 70.54.27%, respectively). This research suggests that the ethanolic extract of AF roots can potentially be used for hepatocarcinoma treatment.
Co-Authors Alia, Dina Annisa, Siti Nur Elvia, Elvia Fahriani, Marhami Farhana, Rika Hanifah Yusuf Razali, Rezania T.R, T. Husni Teuku Romi Imansyah Putra