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All Journal Jurnal Ilmiah Pharmacy Indonesian Journal of Pharmaceutical Education
Qiftiah, Mariatul
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Formulation of an Antibacterial Peel-Off Gel Mask from Kombucha Fermented with Gerga Orange Peel Infusion (Citrus x aurantium L.) Joevanda, Salsabila; Salsabilla, Navira; Qiftiah, Mariatul; Sani K, Fathnur; Sukmadani Rusdi, Mesa; Efendi, M. Rifqi
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28769

Abstract

Kombucha fermentation transforms complex organic compounds into beneficial substances such as polyphenols, vitamins, minerals, fiber, and probiotics. Gerga orange (Citrus x aurantium L.) peel, rich in bioactive compounds with antibacterial potential, is a promising substrate for kombucha fermentation. This study aimed to develop a fermented kombucha infusion from Gerga orange peel for use in an antibacterial peel-off gel mask and to assess the impact of hydroxypropyl methylcellulose (HPMC) concentrations (2%, 3%, and 4%) on the mask's properties. Extract preparation, organoleptic evaluation, total phenolic content (TPC) analysis, and gel mask formulation were conducted. Antibacterial activity was evaluated against Propionibacterium acnes using the well-diffusion method. Kombucha fermentation increased the TPC of Gerga orange peel infusion (26.53 mgGAE/g vs 25.77 mgGAE/g), imparted a fermentation aroma, and reduced pH from 4 to 2.7. HPMC concentration significantly influenced gel texture, spreadability, drying time, and pH, while color, aroma, and homogeneity remained unaffected. Antibacterial tests showed moderate activity for Formula 1 (2% HPMC; inhibition zone: 9.25 ± 0.35 mm). Stronger antibacterial effects were observed in Formulas 2 (3% HPMC; 13.93 ± 0.49 mm) and 3 (4% HPMC; 14.25 ± 0.71 mm). Kombucha fermentation of Gerga orange peel offers an innovative method for creating antibacterial gel masks. Higher HPMC concentrations improve antibacterial efficacy and physical properties, demonstrating potential against Propionibacterium acnes.
ANALISIS KADAR FENOL DAN FLAVONOID TOTAL EKSTRAK ETANOL 70% DAUN EKOR NAGA (Raphidopora Pinnata) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Kasmadi, Fathnur Sani; Elisma, Elisma; Qiftiah, Mariatul; Adisty, Aura Rasyanda; Usna, Rozatul
Jurnal Ilmiah Pharmacy Vol 12, No 1 (2025)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v12i1.621

Abstract

Daun ekor naga merupakan tanaman herbal yang sangat banyak dimanfaatkan oleh masyarakat sebagai tanaman hias dan terapi penyakit. Adanya kandungan senyawa metabolit sekunder membuktikan bahwa tanaman ini memiliki kandungan senyawa fenol total dan flavonoid total. Tujuan dari penelitian ini adalah untuk memastikan kandungan senyawa fenol total dan flavonoid total yang memiliki potensi dalam aktivitas penangkal radikal bebas yang kuat. Metode penelitian dilakukan secara eksperimental menggunakan pelarut etanol 70% untuk proses maserasi. Pengujian diukur menggunakan spektrofotometri UV-Vis hasil flavonoid total yang didapat dinyatakan dalam mgQE/g Sampel dan fenol total dinyatakan dalam mg GAE/g sampel. ekstrak etanol 70% daun ekor naga memiliki kandungan senyawa fenol total sebesar 23,84 mg GAE/gram sampel dan flavonoid total sebesar 9,75 mg QE/gram sampel.Kata Kunci : Daun Ekor Naga, Fenol, Flavonoid, Spektrofotometer Uv-Vis
Co-Authors Adisty, Aura Rasyanda Elisma Elisma Joevanda, Salsabila M. Rifqi Efendi Mesa Sukmadani Rusdi Salsabilla, Navira Sani K, Fathnur Usna, Rozatul