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Teratogenic Effects of Durian Fruit (Durio Zibethinus Murr) on White Mice Fetus (Mus musculus L) Rusdi, Mesa Sukmadani; Efendi, M. Rifqi; Hilma, Hafizhatul
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 7, No 1 (2021): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/pharmauho.v7i1.13489

Abstract

Durian (Durio zibethinus L.) is one of the most consumed and liked fruit in Indonesia, but there was no evidence about the safety of consuming durian during pregnancy. This study was determine the level of safety of durian fruit consumption during pregnancy by conducted teratogenicity test of durian fruit (Durio zibethinus Linn) on fetuses of white mice (Mus musculus L). Teratogenicity test was conducted in vivo, by step: preparation of experimental animal, observation during administration, laparotomy, fixation and observation of morphological defects. Data were analyzed using Analysis of Variance (ANOVA). If the results were significant (P < 0.05), the analysis was continued using Duncan Multiple Range Test. Administration durian during pregnancy did not affects the bodyweight of the mice (P > 0,05), but significantly influences the number of fetuses (P < 0,05) and its body weight (P < 0,05). Consumption of durian during pregnancy is safe in 32,5 mg / KgBW, but it has the potential teratogenic in 65 mg / KgBW and 97,5 mg/KgBW groups. Teratogen effects that were found in several fetuses were underweight, dead, hemorrhage, maternal death and there were resorption sites.
Antibacterial activity of ethyl acetate extracts of fungal endophytes isolated from leaf gambir leaves (Uncaria gambir (Hunter) Roxb) M. Rifqi Efendi; Mesa Sukmadani Rusdi; Anita Dinda
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (463.54 KB) | DOI: 10.12928/mf.v19i1.20483

Abstract

Gambir (Uncaria gambir (Hunter) Roxb) is a Sumatran medicinal plant that has various bioactivities, including antibacterial. This study aims to isolate endophytic fungi from gambier leaves and test the antibacterial activity of ethyl acetate extracts of fungal endophytes from gambir leaves. The fungal endophytes were isolated by inoculating the fungus obtained from gambir leaves on potato dextrose agar (PDA) media. The fungal endophytes were identified microscopically and macroscopically. Furthermore, the fungal endophytes were cultivated using rice media : aquades (100 : 110). The cultivated fungus was macerated using ethyl acetate solvent and tested using a screening test. The antibacterial activity of the ethyl acetate extract of endophytic fungi was conducted using the agar diffusion method against Gram-positive bacteria (Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 25923) and Gram-negative bacteria (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853). This study has revealed five fungal isolates from gambir leaves and identified the isolates as Penicillium sp 1 (0.39 g), Penicillium sp 2 (0.26 g), Neopestalotiopsis sp (0.97 g), Colletotrichum capsici (0.46 g), and Aspergillus sp (0.25 g). The ethyl acetate extracts of each fungal endophyte show the presence of phenolic compounds and have inhibition against Gram-positive and Gram-negative bacteria. The highest antibacterial activity is shown by ethyl acetate extracts of the fungal endophytes of Neopestalotiopsis sp at a concentration of 7.5% on P. aeruginosa ATCC 27853 23±3.9 mm and S. aureus ATCC 25923 14±2.5 mm. Tests on B. subtilis ATCC 6633 and E. coli ATCC 25922 with the highest inhibition zones were indicated by the ethyl acetate extracts of the fungus Aspergillus sp of 15.3±4 mm and 14±1.9 mm, respectively.
Konseling Penggunaan dan Pembagian Multivitamin Gratis pada Masa Pandemi Covid-19 di Kelurahan Piai tangah Kota Padang Rosiana Rizal; Helmice Afriyeni; Sefrianita Kamal; Sara Surya; Mesa Sukmadani Rusdi; M. Rifqi Efendi; Nofrizal; Afriyani
Jurnal Pengabdian Masyarakat Indonesia Vol 2 No 2 (2022): JPMI - April 2022
Publisher : CV Infinite Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52436/1.jpmi.383

Abstract

Indonesia telah menerapkan Pembatasan Sosial Berskala Mikro (PPKM) sebagai respon terhadap peningkatan kasus Covid-19. Menurut tim tracing kelurahan Piai tangah dari bulan Juli tahun 2021, terjadi peningkatan jumlah kasus reaktif dan positif Covid-19 di kelurahan Piai Tangah yang terletak di Kota Padang. Oleh karena itu, pengabdian ini bertujuan untuk mencegah penyebaran infeksi covid-19 di wilayah ini. Metode pengabdian yang dilakukan di masyarakat antara lain pembagian multivitamin, pemberian informasi tentang Covid-19, seperti gejala infeksi dan cara pencegahannya, serta penyuluhan penggunaan multivitamin untuk meningkatkan derajat kesehatan masyarakat Piai Tangah di kecamatan Pauh yang terletak di kota Padang. Hasil kegiatan pengabdian ini sangat diminati masyarakat karena memenuhi kebutuhan kesehatan masyarakat Piai Tangah yang terpapar Covid-19 dengan mendapatkan multivitamin sebagai peningkatan sistim imun terhadap covid-19. Selain itu, terdapat respon positif dari masyarakat yang meyakini bahwa kegiatan pengabdian diperlukan untuk meningkatkan daya tahan tubuh, dimana mayoritas (75%) memahami gejala dan tindakan pencegahan Covid-19, serta cara mengkonsumsi multivitamin dengan tepat dan benar dari konseling yang dilakukan.
Edukasi Penerapan Perilaku Hidup Bersih dan Sehat (PHBS) sebagai Upaya Pencegahan Penyebaran Covid-19 Mesa Sukmadani Rusdi; M. Rifqi Efendi; Rustini; Afriyani; Lusia Eka P Putri; Sefrianita Kamal; Sara Surya
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 1 No. 1 (2021): Januari 2021 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (4215.587 KB) | DOI: 10.25008/altifani.v1i1.123

Abstract

Corona virus atau COVID-19 merupakan infeksi virus yang ditemukan pada akhir 2019 di kota Wuhan, China. Penyebaran yang masif membuat sekitar lebih dari 900 ribu masyarakat Indonesia telah terjangkit infeksi COVID-19. Meskipun demikian, terdapat beberapa cara yang bisa dilakukan untuk mengurangi risiko dan mencegah penularan, salah satunya dengan penerapan Perilaku Hidup Bersih dan Sehat (PHBS), penggunaan hand sanitizer dan masker. Pengabdian masyarakat dilaksanakan di Panti Asuhan Muhammadiyah Cabang Pauh IX, Padang, Sumatera Barat. Panti asuhan merupakan salah satu tempat yang rentan dalam penularan COVID-19. Hal ini dikarenakan panti asuhan tersebut merupakan tempat hidup dan berkumpulnya anak - anak dalam jumlah yang besar. Maka dari itu, Program Studi Farmasi Universitas Dharma Andalas mengadakan pengabdian masyarakat dengan memberikan hand sanitizer dan masker sebagai upaya penerapan perilaku hidup bersih dan sehat, serta upaya memutus mata rantai COVID-19.
EDUKASI PENGGUNAAN ANTIBIOTIK YANG BIJAK PADA TENAGA KEPENDIDIKAN UNIVERSITAS DHARMA ANDALAS Afriyani Afriyani; Mesa Sukmadani Rusdi; M.Rifqi Efendi
Ruang Pengabdian : Jurnal Pengabdian Kepada Masyarakat Vol 2, No 2 (2022): RUANG PENGABDIAN
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Antibiotics are substances that are very useful in killing and inhibiting the growth of microorganisms, especially bacteria. Inappropriate use of antibiotics can occur due to lack of information from health workers, especially pharmacists and misuse of antibiotics because they are easy to obtain without a doctor's prescription, sudden discontinuation of treatment, excessive doses, use of residual antibiotics, and use of antibiotics for an inappropriate period of time. The need for education to minimize the occurrence of inappropriate use of antibiotics. This counseling activity aims to provide education to the public, especially Dharma Andalas University education staff on the proper use of antibiotics and to determine the effect of providing education on increasing knowledge about the use of antibiotics. This service method is a participatory community empowerment method, namely a method that emphasizes community involvement in a series of activities, with a pre-test and post-test. Data were analyzed using paired t-test. This community service activities ran smoothly and successfully. Based on the evaluation, there is an increase in knowledge of the proper use of antibiotics. There is a significant difference between before and after education and increasing the knowledge of education staff on the proper and wise use of antibiotics (p 0.05). It is hoped that through this counseling, the community will become aware of the use and handling of drugs, especially antibiotics. AbstrakAntibiotik merupakan suatu substansi yang sangat bermanfaat dalam membunuh dan menghambat pertumbuhan mikroorganisme, terutama bakteri. Pemakaian antibiotik yang tidak tepat dapat terjadi karena kurangnya informasi dari tenaga kesehatan, terutama apoteker dan penyalahgunaan antibiotika karena mudah didapat tanpa resep dokter, penghentian pengobatan secara tiba-tiba, dosis yang berlebihan, penggunaan sisa antibiotik, dan penggunaan antibiotik dengan jangka waktu yang tidak tepat. Perlunya edukasi untuk meminimalisir terjadinya penggunaan antibiotik yang tidak tepat. Kegiatan penyuluhan ini bertujuan untuk memberikan edukasi kepada masyarakat khususnya tenaga kependidikan Universitas Dharma Andalas terhadap penggunaan antibiotik yang tepat serta untuk mengetahui pengaruh pemberian edukasi terhadap peningkatan pengetahuan tentang penggunaan antibiotik. Metode pengabdian ini adalah metode pemberdayaan masyarakat partisipatif, yaitu metode yang menekankan keterlibatan masyarakat pada rangkaian kegiatan, dengan pre-test dan post-test. Data dianalisis menggunakan Uji T-berpasangan. Kegiatan penyuluhan berjalan dengan lancar dan sukses. Terdapat perbedaan yang signifikan antara sebelum dan setelah edukasi dan peningkatan pengetahuan tenaga kependidikan terhadap penggunaan antibiotik yang tepat dan bijak (p 0,05). Diharapkan melalui penyuluhan ini terwujud masyarakat menjadi sadar dalam pengunaan dan penanganan obat, khususnya antibiotik. DOI: https://doi.org/10.23960/rp/v2i2.hal.129-137
Evaluation of Coffee Mistletoe Leaf Ethanol Extract on Burn Healing Activity on White Male Rat M. Rifqi Efendi; Diah Riski Gusti; Annisa Dhita Syahrial; Mesa Sukmadani Rusdi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.72

Abstract

Burns are injuries that can be caused by heat (fire, hot liquids/fats, hot vapors), radiation, electricity, or chemicals. Coffee mistletoe leaves (Loranthus ferruginous Roxb) are one type of plant that contains secondary metabolite compounds, such as flavonoids, tannins, saponins, alkaloids, and phenolics, which play a role in the burn healing effects. This research was conducted using an experimental research method with a Completely Randomized Design (CRD) and a post-test only control group design approach. A total of 25 rats were divided into five treatment groups for the study. The groups included a positive control group treated with Bioplacenton gel, a negative control group treated with yellow vaseline, and three experimental groups treated with different concentrations of ethanol extract of coffee mistletoe leaves. The concentrations used were 5% (P1), 10% (P2), and 15% (P3). The burn healing activity and hydroxyproline content were observed as outcome measures. The data were presented as mean ± SD and analyzed using one-way ANOVA. Subsequently, Duncan's multiple rank test was performed to determine any significant differences. A significance level of p<0.05 was considered to define statistically significant results. The results of the study showed that ethanol extract of coffee mistletoe leaves has an effect as a burn treatment, with the best concentration found at 15% concentration, which had a healing percentage of 62.5%, although its effectiveness did not exceed that of the positive control group (72,48%). The hydroxyproline content of the coffee mistletoe leaf extract group demonstrated significant difference when compared to control negative groups, especially P1 group (53.62±6.52 μg/mL), and statistically not different with positive control (64.34 ±6.02 μg/mL). For the P2 and P3 groups, the hydroxyproline content were increased but did not reach significant value. Wound-healing activity owing to its richness in various effective chemical compounds present in the extract such as phenolics, saponin, flavonoid and alkaloid. Further investigation is necessary to identify and understand these additional components and their mechanisms of action in the healing process.
Edukasi Peduli Obat “Dagusibu” (Dapatkan, Gunakan, Simpan, Buang) M.Rifqi Efendi; Mesa Sukmadani Rusdi; Rustini Rustini; Sefrianita Kamal; Sara Surya; Lusia Eka Putri; Afriyani Afriyani
Abdimas Mandalika Vol 1, No 1 (2021): Agustus
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/am.v1i1.5790

Abstract

DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) merupakan bagian dari Gerakan Keluarga Sadar Obat (GKSO) yang diprakarsai Ikatan Apoteker Indonesia (IAI) dalam mencapai pemahaman dan kesadaran masyarakat, khususnya pada ibu – ibu terhadap penggunaan obat dengan benar. Kegiatan penyuluhan Peduli Edukasi ObatDAGUSIBU memiliki tujuan membantu masyarakat setempat,khususnya ibu - ibu dalam pengelolaan obat baik di lingkungan keluarga maupun masyarakat secara umum. Penyuluhan dilakukan dengan metode pemberdayaan masyarakat partisipatif, yaitu metode yang menekankan keterlibatan masyarakat pada rangkaian kegiatan. Kegiatan penyuluhan berjalan dengan lancar dan sukses. Berdasarkan obersevasi, terdapat peningkatan pemahaman dan pengetahuan ibu ibu PKK menjawab dengan benar pertanyaan dari tim penyuluh. 
PELATIHAN PEMBUATAN SNACK HERBAL SEBAGAI UPAYA PEMBERDAYAAN MASYARAKAT ANAK SUKU DALAM DI DESA PELEMPANG KABUPATEN MUARO JAMBI Fathnur Sani K; M.Rifqi Efendi; Puspa Dwi Pertiwi; Elisma Elisma; Yuliawati Yuliawati; Maimum Maimum; Indri Maharini
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 6 No. 2 (2023): MEDIC. Medical dedication
Publisher : Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/medicaldedication.v6i2.28152

Abstract

ABSTRACTJambi Province is one of the areas most inhabited by the Anak Dalam Tribe (SAD). Their estimated population in Jambi province alone is around 200,000 people. SAD life itself is often known as hunting and gathering to meet life's needs. Pelempang, Muaro Jambi Regency is one of the areas in Mestong village/sub-district, Muaro Jambi Regency, Jambi Province. Their distance which is quite far from the outside environment makes them live more by utilizing natural materials as a means of fulfilling their daily needs, ranging from food to medical needs. Herbal plants are a type of plant that is able to provide pharmacological effects on the body. In the last few years, we have been surprised by the emergence of a disease condition caused by a virus, namely the corona virus, better known as COVID-19. This condition requires us to always try to improve our health or body immunity to minimize the bad effects of this virus attack. So that many herbal products have emerged that are beneficial to the immune system, both in the form of beverage products and in the form of snacks so that what used to be known by the public about herbal medicines is a medicine that is not tasty and comfortable to consume, and has become a product that is delicious to eat and has benefits for the body's immunity. The distance of access means that education for the SAD community is also minimal. So it is important to provide additional knowledge to improve their quality of life and be able to blend in with the surrounding community. The solution offered in this activity is to provide knowledge and training about the importance of maintaining health and how to use medicinal plants to be given training in making herbal snacks which have many health benefits. This service activity will be carried out in Pelempang village, Maestong sub-district, Muaro Jambi district, Jambi province. This activity was carried out offline and was attended by 30 participants. The results of the activity show that there is additional knowledge for the SAD community in the process of processing herbal products that are delicious to enjoy.Keywords: snacks, SAD, Herbal, Palempang Village ABSTRAK Provinsi jambi merupakan salah satu wilayah yang paling banyak ditempati oleh Suku Anak Dalam (SAD). Perkiraan jumlah populasi mereka di provinsi jambi sendiri adalah sekitar 200.000 orang. Kehidupan SAD sendiri sering dikenal dengan berburu dan meramu guna memenuhi kebutuhan hidup. Pelempang, kabupaten muaro jambi merupakan salah satu daerah yang berada didesa/kelurahan Mestong Kabupaten Muaro Jambi, Provinsi Jambi. Jarak mereka yang cukup jauh dari lingkungan luar membuat mereka hidup lebih memanfaatkan bahan alam sebagai sarana pemenuhan kebutuhan hidup mulai dari makanan hingga untuk medis. Tanaman herbal merupakan jenis tanaman yang mampu memberikan efek farmakologis bagi tubuh. Beberapa tahun terakhir kita sempat dikejutkan dengan munculnya kondisi penyakit yang disebabkan oleh virus yaitu corona virus yang lebih dikenal dengan COVID-19. Kondisi ini menuntut kita untuk selalu berupaya meningkatkan kesehatan atau imunitas tubuh untuk meminimalisir efek buruk dari serangan virus tersebut. Sehingga telah banyak bermunculan produk-produk herbal yang bermanfaat bagi kekebalan tubuh baik itu berbentuk produk minuman maupun berbentuk snack sehingga yang dulunya masyarakat mengenal obat herbal merupakan obat yang tidak enak dan nyaman dikonsumsi menjadi produk yang nikmat untuk d makan dan memiliki manfaat bagi imunitas tubuh. Jauhnya akses membuat pendidikan bagi masyarakat SAD juga minim. Sehingga pentingnya memberi pengetahuan tambahan untuk memperbaiki kualitas hidup mereka dan dapat berbaur dengan masyarakat sekitar. Solusi yang ditawarkan pada kegiatan ini adalah Memberikan pengetahuan dan pelatihan tentang pentingnya menjaga kesehatan dan cara pemanfaatan tanaman berkhasiat obat untuk diberikan pelatihan pembuatan snack herbal yang memiliki banyak manfaat bagi kesehatan. Kegiatan pengabdian ini akan dilaksanakan di desa pelempang kelurahan maestong kabupaten muaro jambi provinsi jambi. Kegiatan ini dilakukan secara offline yang dihadiri sebanyak 30 orang peserta. Hasil kegiatan menunjukkan adanya tambahan pengetahuan bagi masyarakat SAD dalam proses pengolahan produk herbal yang enak untuk di nikmati. Kata kunci: snack, SAD, Herbal, Desa Palempang
EDUKASI PENCEGAHAN STUNTING DI PEKON PAMPANGAN, LAMPUNG BARAT Afriyani; Ervina Damayanti; Suryadi Islami; M. Rifqi Efendi; Mesa Sukmadani Rusdi
Jurnal Pengabdian Multidisiplin Indonesia (JUPEMI) Vol. 1 No. 1 (2023): Juni
Publisher : Merwinspy Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69820/jupemi.v1i1.21

Abstract

Stunting adalah kondisi gagal tumbuh pada anak-anak yang ditandai dengan pertumbuhan dan perkembangan fisik yang terhambat. Walaupun hasil Studi Status Gizi Indonesia (SSGI) 2021 telah menunjukkan penurunan angka stunting nasional dari 27,7% pada tahun 2019 menjadi 24,4% pada tahun 2021. Namun, angka tersebut masih dikategorikan tinggi menurut WHO (>20%). Penyuluhan ini bertujuan untuk memberikan edukasi kepada masyarakat khususnya kader Posyandu, ibu hamil, ibu menyusui dan ibu yang memiliki balita di Pekon Pampangan, Kecamtan Sekincau, Kabupaten Lampung Barat terhadap pencegahan stunting. Metode pengabdian ini adalah metode pemberdayaan masyarakat partisipatif, yaitu metode yang menekankan keterlibatan masyarakat pada rangkaian kegiatan. Kegiatan penyuluhan pencegahan stunting berjalan dengan lancar dan sukses. Evaluasi menunjukkan adanya peningkatan pengetahuan peserta. Diharapkan bahwa penyuluhan ini akan meningkatkan kesadaran masyarakat mengenai tumbuh kembang anak, sehingga dapat mencegah terjadinya stunting dan menurunkan persentase stunting di Indonesia, terutama di Pekon Pampangan, Kecamatan Sekincau, Kabupaten Lampung Barat.
Formulation of an Antibacterial Peel-Off Gel Mask from Kombucha Fermented with Gerga Orange Peel Infusion (Citrus x aurantium L.) Joevanda, Salsabila; Salsabilla, Navira; Qiftiah, Mariatul; Sani K, Fathnur; Sukmadani Rusdi, Mesa; Efendi, M. Rifqi
Indonesian Journal of Pharmaceutical Education Vol 4, No 3 (2024): September-Desember 2024
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v4i3.28769

Abstract

Kombucha fermentation transforms complex organic compounds into beneficial substances such as polyphenols, vitamins, minerals, fiber, and probiotics. Gerga orange (Citrus x aurantium L.) peel, rich in bioactive compounds with antibacterial potential, is a promising substrate for kombucha fermentation. This study aimed to develop a fermented kombucha infusion from Gerga orange peel for use in an antibacterial peel-off gel mask and to assess the impact of hydroxypropyl methylcellulose (HPMC) concentrations (2%, 3%, and 4%) on the mask's properties. Extract preparation, organoleptic evaluation, total phenolic content (TPC) analysis, and gel mask formulation were conducted. Antibacterial activity was evaluated against Propionibacterium acnes using the well-diffusion method. Kombucha fermentation increased the TPC of Gerga orange peel infusion (26.53 mgGAE/g vs 25.77 mgGAE/g), imparted a fermentation aroma, and reduced pH from 4 to 2.7. HPMC concentration significantly influenced gel texture, spreadability, drying time, and pH, while color, aroma, and homogeneity remained unaffected. Antibacterial tests showed moderate activity for Formula 1 (2% HPMC; inhibition zone: 9.25 ± 0.35 mm). Stronger antibacterial effects were observed in Formulas 2 (3% HPMC; 13.93 ± 0.49 mm) and 3 (4% HPMC; 14.25 ± 0.71 mm). Kombucha fermentation of Gerga orange peel offers an innovative method for creating antibacterial gel masks. Higher HPMC concentrations improve antibacterial efficacy and physical properties, demonstrating potential against Propionibacterium acnes.