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All Journal Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Martabe : Jurnal Pengabdian Kepada Masyarakat Journal Syifa Sciences and Clinical Research (JSSCR) Lumbung Farmasi : Jurnal Ilmu Kefarmasian JK Unila (Jurnal Kedokteran Universitas Lampung) Mattawang: Jurnal Pengabdian Masyarakat MEDIC MEdical Dedication Jurnal Pengabdian Masyarakat Indonesia Nursing Care and Health Technology Journal (NCHAT) Indonesian Journal of Pharmaceutical Education Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Ruang Pengabdian : Jurnal Pengabdian Kepada Masyarakat Jurnal Hasi Penelitian Dan Pengkajian Ilmiah Eksakta - JPPIE Journal of Pharmaceutical and Sciences. Abdimas Mandalika Borneo Journal of Pharmacy Jurnal Pengabdian Multidisiplin Indonesia

Mesa Sukmadani Rusdi

Program Studi Farmasi, Poltekkes Kemenkes Jambi, Jambi, Indonesia

Author-ID : 3786267

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Teratogenic Effects of Durian Fruit (Durio Zibethinus Murr) on White Mice Fetus (Mus musculus L) Rusdi, Mesa Sukmadani; Efendi, M. Rifqi; Hilma, Hafizhatul
Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan Vol 7, No 1 (2021): Pharmauho
Publisher : Fakultas Farmasi Universitas Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33772/pharmauho.v7i1.13489

Durian (Durio zibethinus L.) is one of the most consumed and liked fruit in Indonesia, but there was no evidence about the safety of consuming durian during pregnancy. This study was determine the level of safety of durian fruit consumption during pregnancy by conducted teratogenicity test of durian fruit (Durio zibethinus Linn) on fetuses of white mice (Mus musculus L). Teratogenicity test was conducted in vivo, by step: preparation of experimental animal, observation during administration, laparotomy, fixation and observation of morphological defects. Data were analyzed using Analysis of Variance (ANOVA). If the results were significant (P < 0.05), the analysis was continued using Duncan Multiple Range Test. Administration durian during pregnancy did not affects the bodyweight of the mice (P > 0,05), but significantly influences the number of fetuses (P < 0,05) and its body weight (P < 0,05). Consumption of durian during pregnancy is safe in 32,5 mg / KgBW, but it has the potential teratogenic in 65 mg / KgBW and 97,5 mg/KgBW groups. Teratogen effects that were found in several fetuses were underweight, dead, hemorrhage, maternal death and there were resorption sites.

Antibacterial activity of ethyl acetate extracts of fungal endophytes isolated from leaf gambir leaves (Uncaria gambir (Hunter) Roxb) M. Rifqi Efendi; Mesa Sukmadani Rusdi; Anita Dinda
Media Farmasi: Jurnal Ilmu Farmasi Vol 19, No 1: March 2022
Publisher : Universitas Ahmad Dahlan

Gambir (Uncaria gambir (Hunter) Roxb) is a Sumatran medicinal plant that has various bioactivities, including antibacterial. This study aims to isolate endophytic fungi from gambier leaves and test the antibacterial activity of ethyl acetate extracts of fungal endophytes from gambir leaves. The fungal endophytes were isolated by inoculating the fungus obtained from gambir leaves on potato dextrose agar (PDA) media. The fungal endophytes were identified microscopically and macroscopically. Furthermore, the fungal endophytes were cultivated using rice media : aquades (100 : 110). The cultivated fungus was macerated using ethyl acetate solvent and tested using a screening test. The antibacterial activity of the ethyl acetate extract of endophytic fungi was conducted using the agar diffusion method against Gram-positive bacteria (Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 25923) and Gram-negative bacteria (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853). This study has revealed five fungal isolates from gambir leaves and identified the isolates as Penicillium sp 1 (0.39 g), Penicillium sp 2 (0.26 g), Neopestalotiopsis sp (0.97 g), Colletotrichum capsici (0.46 g), and Aspergillus sp (0.25 g). The ethyl acetate extracts of each fungal endophyte show the presence of phenolic compounds and have inhibition against Gram-positive and Gram-negative bacteria. The highest antibacterial activity is shown by ethyl acetate extracts of the fungal endophytes of Neopestalotiopsis sp at a concentration of 7.5% on P. aeruginosa ATCC 27853 23±3.9 mm and S. aureus ATCC 25923 14±2.5 mm. Tests on B. subtilis ATCC 6633 and E. coli ATCC 25922 with the highest inhibition zones were indicated by the ethyl acetate extracts of the fungus Aspergillus sp of 15.3±4 mm and 14±1.9 mm, respectively.

Mini Review: Farmakologi pada Corona Virus Disease (Covid-19) Mesa Sukmadani Rusdi
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 2, No 1 (2021): JANUARI
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v2i1.3974

ABSTRAKCorona virus disease 2019 (Covid-19) merupakan penyakit infeksi yang disebabkan oleh virus SARS-CoV-2 yang pertama kali ditemukan di Wuhan, China pada bulan Desember 2019. Virus ini menyebar ke seluruh dunia dengan sangat cepat dan melumpuhkan ekonomi dan kesehatan pada berbagai negara. Oleh karena itu, perkembangan penemuan obat baru dan penggunaan obat lama yang aman menjadi opsi untuk terapi dan pencegahan Covid-19. Belum terdapat terapi yang efektif terhadap virus ini. Remdesivir merupakan terapi yang paling menjanjikan dan merupakan satu – satunya obat yang disetujui FDA sebagai terapi pengobatan Covid-19. Studi terbatas terkait penggunaan obat antiviral, seperti lopinavir/ ritonavir, oseltamivir sebagai terapi Covid-19. Adanya efek samping yang membahayakan pada klorokuin dan hidroklorokuin, sehingga penggunaannya tidak direkomendasikan. Penggunaan kortekosteroid direkomendasikan pada pasien dengan gejala Covid-19 parah dengan ventilator dan dengan alat bantu oksigen. Keputusan penggunaan obat pada Covid-19 dalam kondisi pandemi sebaiknya berdasarkan pertimbangan dan kehati-hatian benefit dan risiko terhadap pasienKata kunci : farmakologi; Covid-19; SARS-CoV-2; Corona virus.ABSTRACTCorona virus disease 2019 (Covid-19) is an infectious disease caused by the SARS-CoV-2 virus which was first discovered in Wuhan, China in December 2019. This virus spreads throughout the world very quickly and paralyzes the economy and health in various countries. Therefore, the development of new drug discoveries and the use of safe old drugs are options for the therapy and prevention of Covid-19. There is no effective therapy against this virus. Remdesivir is the most promising therapy and is the only drug approved by the FDA to treat Covid-19. Limited studies related to the use of antiviral drugs, such as lopivinavir/ ritonavir, oseltamivir as Covid-19 therapy. There are harmful side effects to chloroquine and hydrochloroquine, so the use of these drugs are not recommended. The use of cortecosteroids is recommended in patients with severe Covid-19 symptoms on a ventilator and on oxygen assisted devices. The decision to use drugs in Covid-19 in a pandemic condition should be based on careful consideration of the benefit and risk for the patient.Keywords : pharmacology; Covid-19; SARS-CoV-2; Corona virus.

Konseling Penggunaan dan Pembagian Multivitamin Gratis pada Masa Pandemi Covid-19 di Kelurahan Piai tangah Kota Padang Rosiana Rizal; Helmice Afriyeni; Sefrianita Kamal; Sara Surya; Mesa Sukmadani Rusdi; M. Rifqi Efendi; Nofrizal; Afriyani
Jurnal Pengabdian Masyarakat Indonesia Vol 2 No 2 (2022): JPMI - April 2022
Publisher : CV Infinite Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52436/1.jpmi.383

Indonesia telah menerapkan Pembatasan Sosial Berskala Mikro (PPKM) sebagai respon terhadap peningkatan kasus Covid-19. Menurut tim tracing kelurahan Piai tangah dari bulan Juli tahun 2021, terjadi peningkatan jumlah kasus reaktif dan positif Covid-19 di kelurahan Piai Tangah yang terletak di Kota Padang. Oleh karena itu, pengabdian ini bertujuan untuk mencegah penyebaran infeksi covid-19 di wilayah ini. Metode pengabdian yang dilakukan di masyarakat antara lain pembagian multivitamin, pemberian informasi tentang Covid-19, seperti gejala infeksi dan cara pencegahannya, serta penyuluhan penggunaan multivitamin untuk meningkatkan derajat kesehatan masyarakat Piai Tangah di kecamatan Pauh yang terletak di kota Padang. Hasil kegiatan pengabdian ini sangat diminati masyarakat karena memenuhi kebutuhan kesehatan masyarakat Piai Tangah yang terpapar Covid-19 dengan mendapatkan multivitamin sebagai peningkatan sistim imun terhadap covid-19. Selain itu, terdapat respon positif dari masyarakat yang meyakini bahwa kegiatan pengabdian diperlukan untuk meningkatkan daya tahan tubuh, dimana mayoritas (75%) memahami gejala dan tindakan pencegahan Covid-19, serta cara mengkonsumsi multivitamin dengan tepat dan benar dari konseling yang dilakukan.

Hipoglikemia Pada Pasien Diabetes Melitus Mesa Sukmadani Rusdi
Journal Syifa Sciences and Clinical Research Vol 2, No 2 (2020): Volume 2 Edisi 2 2020
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v2i2.4575

Diabetes mellitus (DM) is a metabolic disorder characterized by an increase in insulin due to decreased insulin secretion by pancreatic beta cells and/ or insulin resistance. Hypoglycemia is one of the main risks that DM patients often to suffer. in Type 2 DM, hypoglycemia is the most common side effect of the use of insulin and sulfonylureas. It is because of their modes of action . Hypoglycaemia presents a major barrier to satisfactory long term glycemic control and remains a feared complication of diabetes treatment. Acute and chronic complications of hypoglycemia can interfere with life, such as social interactions, sleep, sexual activity, driving, sports, and other activities. Blood glucose monitoring needs to be done to prevent the risk of hypoglycemia. Patients treated with insulin, sulfonylureas/glinides are advised to check blood glucose any time hypoglycemia is going to happen.

Edukasi Penerapan Perilaku Hidup Bersih dan Sehat (PHBS) sebagai Upaya Pencegahan Penyebaran Covid-19 Mesa Sukmadani Rusdi; M. Rifqi Efendi; Rustini; Afriyani; Lusia Eka P Putri; Sefrianita Kamal; Sara Surya
Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat Vol. 1 No. 1 (2021): Januari 2021 - Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat
Publisher : Indonesian Scientific Journal

Corona virus atau COVID-19 merupakan infeksi virus yang ditemukan pada akhir 2019 di kota Wuhan, China. Penyebaran yang masif membuat sekitar lebih dari 900 ribu masyarakat Indonesia telah terjangkit infeksi COVID-19. Meskipun demikian, terdapat beberapa cara yang bisa dilakukan untuk mengurangi risiko dan mencegah penularan, salah satunya dengan penerapan Perilaku Hidup Bersih dan Sehat (PHBS), penggunaan hand sanitizer dan masker. Pengabdian masyarakat dilaksanakan di Panti Asuhan Muhammadiyah Cabang Pauh IX, Padang, Sumatera Barat. Panti asuhan merupakan salah satu tempat yang rentan dalam penularan COVID-19. Hal ini dikarenakan panti asuhan tersebut merupakan tempat hidup dan berkumpulnya anak - anak dalam jumlah yang besar. Maka dari itu, Program Studi Farmasi Universitas Dharma Andalas mengadakan pengabdian masyarakat dengan memberikan hand sanitizer dan masker sebagai upaya penerapan perilaku hidup bersih dan sehat, serta upaya memutus mata rantai COVID-19.

EDUKASI PENGGUNAAN ANTIBIOTIK YANG BIJAK PADA TENAGA KEPENDIDIKAN UNIVERSITAS DHARMA ANDALAS Afriyani Afriyani; Mesa Sukmadani Rusdi; M.Rifqi Efendi
Ruang Pengabdian : Jurnal Pengabdian Kepada Masyarakat Vol 2, No 2 (2022): RUANG PENGABDIAN
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Antibiotics are substances that are very useful in killing and inhibiting the growth of microorganisms, especially bacteria. Inappropriate use of antibiotics can occur due to lack of information from health workers, especially pharmacists and misuse of antibiotics because they are easy to obtain without a doctor's prescription, sudden discontinuation of treatment, excessive doses, use of residual antibiotics, and use of antibiotics for an inappropriate period of time. The need for education to minimize the occurrence of inappropriate use of antibiotics. This counseling activity aims to provide education to the public, especially Dharma Andalas University education staff on the proper use of antibiotics and to determine the effect of providing education on increasing knowledge about the use of antibiotics. This service method is a participatory community empowerment method, namely a method that emphasizes community involvement in a series of activities, with a pre-test and post-test. Data were analyzed using paired t-test. This community service activities ran smoothly and successfully. Based on the evaluation, there is an increase in knowledge of the proper use of antibiotics. There is a significant difference between before and after education and increasing the knowledge of education staff on the proper and wise use of antibiotics (p 0.05). It is hoped that through this counseling, the community will become aware of the use and handling of drugs, especially antibiotics. AbstrakAntibiotik merupakan suatu substansi yang sangat bermanfaat dalam membunuh dan menghambat pertumbuhan mikroorganisme, terutama bakteri. Pemakaian antibiotik yang tidak tepat dapat terjadi karena kurangnya informasi dari tenaga kesehatan, terutama apoteker dan penyalahgunaan antibiotika karena mudah didapat tanpa resep dokter, penghentian pengobatan secara tiba-tiba, dosis yang berlebihan, penggunaan sisa antibiotik, dan penggunaan antibiotik dengan jangka waktu yang tidak tepat. Perlunya edukasi untuk meminimalisir terjadinya penggunaan antibiotik yang tidak tepat. Kegiatan penyuluhan ini bertujuan untuk memberikan edukasi kepada masyarakat khususnya tenaga kependidikan Universitas Dharma Andalas terhadap penggunaan antibiotik yang tepat serta untuk mengetahui pengaruh pemberian edukasi terhadap peningkatan pengetahuan tentang penggunaan antibiotik. Metode pengabdian ini adalah metode pemberdayaan masyarakat partisipatif, yaitu metode yang menekankan keterlibatan masyarakat pada rangkaian kegiatan, dengan pre-test dan post-test. Data dianalisis menggunakan Uji T-berpasangan. Kegiatan penyuluhan berjalan dengan lancar dan sukses. Terdapat perbedaan yang signifikan antara sebelum dan setelah edukasi dan peningkatan pengetahuan tenaga kependidikan terhadap penggunaan antibiotik yang tepat dan bijak (p 0,05). Diharapkan melalui penyuluhan ini terwujud masyarakat menjadi sadar dalam pengunaan dan penanganan obat, khususnya antibiotik. DOI: https://doi.org/10.23960/rp/v2i2.hal.129-137

Studi Literatur Gambaran Kejadian Adverse Drug Reaction (ADR) Pada Obat Substandar dan Obat Palsu Afriyani Afriyani; Dwi Aulia Ramdini; Ervina Damayanti; Anastasya Dian Nurrarti; Arini Puspita Sari; Eka Ananda Laksana Putri; Era Yesica Damanik; Siti Khalimatus Sa'diah; Mesa Sukmadani Rusdi
Jurnal Kedokteran Universitas Lampung Vol 7, No 1 (2023): JURNAL KEDOKTERAN UNIVERSITAS LAMPUNG
Publisher : Fakultas Kedokteran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jkunila71%p

Tanpa disadari produk obat substandar dan palsu telah banyak beredar dan digunakan oleh sebagian besar orang. Obat substandard dan palsu dapat memberi dampak buruk terhadap indivdu, keluargam sistem kesehatan nasional dan ekonomi. Banyak liputan media mengenai obat-obatan palsu terutama produk yang berfokus sebagai obat gaya hidup, seperti tablet pelangsing. Namun, selama empat tahun terakhir database Global Surveillance and Monitoring System for Substandard and Falsiflied Medical Product menerima pemberitahuan mulai dari antibiotik hingga vaksin. Ketika obat-obatan tidak bekerja sebagaimana mestinya, mereka dapat memperpanjang penyakit, memberi ketidaknyamanan dan efek buruk lainnya. Dalam kasus terburuk, beberapa orang meninggal karena penyakit yang tidak diobati atau karena produk obat itu sendiri yang membunuh mereka. Obat substandar dan palsu memiliki potensi akan efek samping/ adverse drug reaction. Penulisan studi pustaka ini bertujuan untuk mengetahui kejadian Adverse Drug Reaction (ADR) yang berkaitan dengan obat substandar dan palsu. Penelusuran pustaka dilakukan dengan menggunakan basis data elektronik Google Scholar, Pubmed, dan Science Direct. Kata kunci yang digunakan “Adverse Drug Reaction”, “Obat substandar”, “pharmacovigilance”. Kriteria inklusi tinjauan pustaka kami adalah jurnal penelitian berbahasa Indonesia dan Inggris dalam rentang penerbitan jurnal 10 tahun terakhir (2013- 2022). Adapun kriteria eksklusi dalam tinjauan pustaka kami adalah jurnal penelitian berbahasa Indonesia dan Inggris yang tidak dapat diakses dan berbayar. Berdasarkan hasil studi pustaka yang termasuk obat substandard dan palsu serta menimbulkan efek samping diantaranya yaitu betalaktam, turunan kloroquin dan artemisin, heroin yang terkontaminasi fentanyl, methylprednisolone, kokain yang terkontaminasi levamisole, amoxicillin, antihipertensi (hidroklorotiazid diuretik), antimalaria, etinil estradiol/norgestrel kombinasi dan dengan salbutamol, clopidogrel dan obat berbasis artemisinin. Adverse Drug Reaction (ADR) dari obat-obat substandar dan palsu dimulai dari infeksi, manifestasi kulit dan meningkatkan mortalitas. Kata Kunci : adverse drug reaction, obat substandar, obat palsu, pharmacovigilance.

Evaluation of Coffee Mistletoe Leaf Ethanol Extract on Burn Healing Activity on White Male Rat M. Rifqi Efendi; Diah Riski Gusti; Annisa Dhita Syahrial; Mesa Sukmadani Rusdi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 3 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i3.72

Burns are injuries that can be caused by heat (fire, hot liquids/fats, hot vapors), radiation, electricity, or chemicals. Coffee mistletoe leaves (Loranthus ferruginous Roxb) are one type of plant that contains secondary metabolite compounds, such as flavonoids, tannins, saponins, alkaloids, and phenolics, which play a role in the burn healing effects. This research was conducted using an experimental research method with a Completely Randomized Design (CRD) and a post-test only control group design approach. A total of 25 rats were divided into five treatment groups for the study. The groups included a positive control group treated with Bioplacenton gel, a negative control group treated with yellow vaseline, and three experimental groups treated with different concentrations of ethanol extract of coffee mistletoe leaves. The concentrations used were 5% (P1), 10% (P2), and 15% (P3). The burn healing activity and hydroxyproline content were observed as outcome measures. The data were presented as mean ± SD and analyzed using one-way ANOVA. Subsequently, Duncan's multiple rank test was performed to determine any significant differences. A significance level of p<0.05 was considered to define statistically significant results. The results of the study showed that ethanol extract of coffee mistletoe leaves has an effect as a burn treatment, with the best concentration found at 15% concentration, which had a healing percentage of 62.5%, although its effectiveness did not exceed that of the positive control group (72,48%). The hydroxyproline content of the coffee mistletoe leaf extract group demonstrated significant difference when compared to control negative groups, especially P1 group (53.62±6.52 μg/mL), and statistically not different with positive control (64.34 ±6.02 μg/mL). For the P2 and P3 groups, the hydroxyproline content were increased but did not reach significant value. Wound-healing activity owing to its richness in various effective chemical compounds present in the extract such as phenolics, saponin, flavonoid and alkaloid. Further investigation is necessary to identify and understand these additional components and their mechanisms of action in the healing process.

Edukasi Peduli Obat “Dagusibu” (Dapatkan, Gunakan, Simpan, Buang) M.Rifqi Efendi; Mesa Sukmadani Rusdi; Rustini Rustini; Sefrianita Kamal; Sara Surya; Lusia Eka Putri; Afriyani Afriyani
Abdimas Mandalika Vol 1, No 1 (2021): Agustus
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/am.v1i1.5790

DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang) merupakan bagian dari Gerakan Keluarga Sadar Obat (GKSO) yang diprakarsai Ikatan Apoteker Indonesia (IAI) dalam mencapai pemahaman dan kesadaran masyarakat, khususnya pada ibu – ibu terhadap penggunaan obat dengan benar. Kegiatan penyuluhan Peduli Edukasi ObatDAGUSIBU memiliki tujuan membantu masyarakat setempat,khususnya ibu - ibu dalam pengelolaan obat baik di lingkungan keluarga maupun masyarakat secara umum. Penyuluhan dilakukan dengan metode pemberdayaan masyarakat partisipatif, yaitu metode yang menekankan keterlibatan masyarakat pada rangkaian kegiatan. Kegiatan penyuluhan berjalan dengan lancar dan sukses. Berdasarkan obersevasi, terdapat peningkatan pemahaman dan pengetahuan ibu ibu PKK menjawab dengan benar pertanyaan dari tim penyuluh.

Co-Authors Afriyani Afriyani Afriyani Afriyani Afriyani Afriyani Afriyani Anastasya Dian Nurrarti Anita Dinda Annisa Dhita Syahrial Arini Puspita Sari Diah Riski Gusti Dinda, Anita Dona Muin DWi Aulia Ramdini Eka Ananda Laksana Putri Era Yesica Damanik Ervina Damayanti Ervina Damayanti Evy Afriyani Fitria Anisa Helmice Afriyeni Hilma, Hafizhatul Hisran, Hisran Joevanda, Salsabila Kamal, Sefrianita Lusia Eka P Putri Lusia Eka Putri M. Rifqi Efendi Nofrizal Qiftiah, Mariatul Rahmah Rahmah Rizal, Rosiana Rosiana Rizal Rustini Rustini Salsabilla, Navira Sani K, Fathnur Sara Surya Sara Surya Sara Surya Sefrianita Kamal Sefrianita Kamal Shandy, Vira Ry Siti Khalimatus Sa'diah Sofiyetti, Sofiyetti Sugiarti Sugiarti Supriadi Supriadi Suryadi Islami

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