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-, Lisnawati
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Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology Public Health

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Efek Tetes Mata Kombinasi Sodium Hialuronat dan Hydroxypropyl-Guar terhadap Stabilitas Lapisan Air Mata pada Mata Kering Terkait Sindrom Sjögren Priya Darsini, Indira; Edwar, Lukman; Rengganis, Iris; -, Lisnawati; Prihartono, Joedo
Cermin Dunia Kedokteran Vol 46, No 1 (2019): Obstetri - Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (798.864 KB) | DOI: 10.55175/cdk.v46i1.539

Abstract

Penelitian ini bertujuan untuk menilai stabilitas lapisan air mata pada mata kering terkait sindrom Sjögren (SS) yang diberi terapi tetes mata kombinasi sodium hialuronat 0,1% (SH) dan hydroxypropyl (HP)-guar, atau monoterapi tetes mata sodium hialuronat (SH). Sebanyak 17 pasien SS dibagi dalam 2 kelompok. Kelompok pertama mendapat kombinasi SH dan HP-guar, kelompok kedua mendapat terapi SH. NIKBUT, Schirmer, skor pewarnaan okular, dan sitologi impresi, serta keluhan subjektif dinilai sebelum dan sesudah pemberian obat. Setelah terapi selama 28 hari, terdapat peningkatan median NIKBUT, Schirmer, skor pewarnaan okular, densitas sel Goblet, dan perbaikan keluhan subjektif pada mata kering terkait SS.The objectives of the study is to assess the stability of dry eye LAM associated with Sjögren syndrome (SS) during combination therapy of sodium hyaluronate 0.1% (SH) and hydroxypropyl (HP) -guar, or monotherapy sodium hyaluronic (SH). A total of 17 SS patients in this study were divided into 2 groups. The first group received a combination of SH and HP-guar while the second group received SH therapy. NIKBUT, Schirmer, ocular staining score, and impression cytology, as well as subjective complaints was assessed before and after drug administration. After 28 days of therapy, there was a median increase in NIKBUT, Schirmer, ocular staining scores, Goblet cell density, and subjective complaints on SS-related dry eyes. 
Exploring the Dynamics of Instagram Content Marketing and Engagement: Its Impact on YouTube Membership Subscription Decisions Putri, Arvianti Farah Natsya; Gaffar, Vanessa; -, Lisnawati; Wibowo, Lili Adi; Khairunnisa, Zahra Nadhira
Journal of Business Management Education (JBME) Vol 10, No 2 (2025)
Publisher : Business Education Program of Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jbme.v10i1.82541

Abstract

The aim of this research is to investigate the influence of content marketing on customer engagement and purchase intention among followers of Jurnalrisa's official Instagram account who have subscribed to the Jurnalrisa YouTube channel. Using path coefficient analysis through Smart PLS, the study found that all hypotheses were supported. The results indicate that content marketing has a positive effect on customer engagement, which in turn also enhances purchase intention. Customer engagement serves as a significant mediating variable, highlighting the importance of customer involvement in the decision-making process. These findings provide valuable insights for marketers to design more effective strategies to boost purchase intention through engaging and relevant content.
Ekspresi Imunoglobulin A pada Sel Plasma di Sekitar Sel Tumor Karsinoma Nasofaring Tidak Berkeratin, Tidak Berdiferensiasi yang Terinfeksi Virus Epstein-Barr Handayani, Ratna; -, Lisnawati; Tanurahardja, Budiana
Majalah Patologi Indonesia Vol. 22 No. 3, September 2013
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

ABSTRAK Latar belakang Karsinoma Nasofaring (KNF) merupakan salah satu keganasan yang sering ditemukan di Indonesia dengan insiden 6,2/100.000 penduduk. Pemeriksaan serologik imunoglobulin A (IgA) terhadap viral capsid antigen (IgA-VCA) merupakan petanda tumor yang digunakan sebagai standar serodiagnostik karena memiliki sensitivitas dan spesifisitas yang tinggi terhadap KNF. Titer antibodi IgA terhadap Epstein-Barr Virus (EBV) meningkat lebih dulu sebelum tampak tumor, dan titer pada usia ≤ 30 tahun lebih rendah daripada usia > 30 tahun. Penelitian ini bertujuan untuk mengevaluasi ekspresi IgA pada jaringan biopsi KNF tidak berkeratin, tidak berdiferensiasi (WHO tipe 3) yang terinfeksi EBV pada kelompok usia ≤ 30 tahun dan usia > 30 tahun. Metode Studi potong lintang terhadap jaringan biopsi pasien KNF WHO tipe 3 yang terinfeksi EBV yang ditandai dengan positifitas EBER pada 13 pasien usia ≤ 30 tahun dan 20 pasien usia > 30 tahun, kemudian dilakukan pemeriksaan imunohistokimia terhadap IgA. Hasil Positivitas EBER ditemukan pada seluruh kasus KNF WHO tipe 3. IgA terekspresi pada epitel permukaan jaringan tumor dan terdapat positifitas ekspresi IgA sel plasma yang berbeda-beda di stroma sekitar jaringan tumor, dengan rerata pada kelompok usia ≤ 30 tahun lebih rendah dari kelompok usia > 30 tahun. Hasil uji t tidak berpasangan menunjukkan adanya perbedaan bermakna antara ekspresi IgA sel plasma pada KNF WHO tipe 3 pada kelompok usia ≤ 30 tahun dan > 30 tahun dengan nilai p=0,025. Kesimpulan Ekspresi IgA sel plasma disekitar jaringan tumor pada jaringan KNF WHO tipe 3 dipengaruhi oleh usia. Kata kunci : Karsinoma nasofaring, virus Epstein-Barr, EBER, IgA. ABSTRACT Background Nasopharyngeal carcinoma (NPC) is one of the most frequent malignant tumors in Indonesia, with incidence rate 6.2/100.000. The IgA-VCA serologic examination is considered as a useful marker for early detection of NPC because its high sensitivity and specificity to NPC. IgA antibody titer to Epstein-Barr Virus (EBV) increased before the tumor arise, and it lower in ≤ 30 years old patients compare to > 30 years old patients. The aim of this study is to evaluated the expression of IgA in biopsy specimen of EBV infected undifferentiated NPC among both ≤ 30 and > 30 years old patients. Methods A cross-sectional retrospective study was performed in 13 young and 20 old groups of age of undifferentiated NPC. The EBER positive undifferentiated NPC was stained with IgA by immunohistochemistry, and then analized it between the two of age groups. Results EBER positivity was found in all undifferentiated NPC. IgA was expressed in the normal surface epithelial submucous plasma cells and stromal plasma cells surounding the tumor mass in all cases of undifferentiated NPC with differented positivity. Statistical analysis with unpaired t test showed that IgA expression is significantly lower in ≤ 30 years old patients than > 30 years old patients with p value 0.025. Conclusion IgA is expressed in plasma cell cytoplasm in the stromal site of undifferentiated NPC and influenced by age. Key words : Nasopharyngeal carcinoma, Epstein-Barr Virus, EBER, IgA.
Co-Authors Budiana Tanurahardja Iris Rengganis Joedo Prihartono Khairunnisa, Zahra Nadhira Lili Adi Wibowo Lukman Edwar Priya Darsini, Indira Putri, Arvianti Farah Natsya Ratna Handayani Vanessa Gaffar