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All Journal Medical Journal of Indonesia Jurnal Ilmu dan Teknologi Kesehatan Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Cermin Dunia Kedokteran The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Iris Rengganis
Faculty of Medicine Universitas Indonesia, Jakarta
Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Medicine & Pharmacology Public Health

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HUBUNGAN ANTARA GANGGUAN DEPRESI DENGAN KUALITAS HIDUP, STRESOR PSIKOSOSIAL, DAN TINGKAT KONTROL ASMA PADA PASIEN ASMA DI RSUPN DR. CIPTO MANGUNKUSUMO Putro, Agung W; Kusumadewi, Irmia; Rengganis, Iris; Agiananda, Feranindhya
Majalah Kedokteran Indonesia Vol 68 No 8 (2018): Journal of the Indonesian Medical Association Majalah Kedokteran Indonesia Volum
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

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Abstract

Pendahuluan: Tingkat kontrol asma buruk dan gangguan komorbid misalnya depresi dan stres psikososial akan memengaruhi kualitas hidup pasien asma serta meningkatkan beban ekonomi yang ditanggung oleh pasien dan keluarganya. Kami menginvestigasi korelasi antara gangguan depresi, kualitas hidup, stresor psikososial dan tingkat kontrol asma pada pasien asma. Metode: Penelitian ini menggunakan metode cross-sectional deskriptif-analitik pada 37 pasien asma penderita depresi dan 37 pasien asma bukan penderita depresi di Poliklinik Alergi dan Imunologi RSCM Jakarta menggunakan kuesioner SCID-1, WHOQOL-BREF, stresor psikososial Holmes & Rahe, dan ACT. Hasil: Terdapat hubungan antara gangguan depresi dengan skor kualitas hidup yang lebih rendah berdasarkan kesehatan fisik (p<0,001), kesehatan psikologis (p<0,001), relasi sosial (p=0,023), lingkungan (p=0,022), stresor psikososial (OR 3,85; p=0,005), dan tingkat kontrol asma (p=0,001) pada pasien asma. Kesimpulan: Pasien asma yang memiliki gangguan depresi cenderung memiliki skor kualitas hidup yang lebih rendah pada semua domain (kesehatan fisik, kesehatan psikologis, hubungan sosial, dan lingkungan) dan skor tingkat kontrol asma lebih rendah dibandingkan pasien asma yang tidak memiliki gangguan depresi. Pasien asma dengan stresor psikososial berisiko 3,8 kali lebih tinggi memiliki gangguan depresi.
Efek Tetes Mata Kombinasi Sodium Hialuronat dan Hydroxypropyl-Guar terhadap Stabilitas Lapisan Air Mata pada Mata Kering Terkait Sindrom Sjögren Priya Darsini, Indira; Edwar, Lukman; Rengganis, Iris; -, Lisnawati; Prihartono, Joedo
Cermin Dunia Kedokteran Vol 46, No 1 (2019): Obstetri - Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (798.864 KB) | DOI: 10.55175/cdk.v46i1.539

Abstract

Penelitian ini bertujuan untuk menilai stabilitas lapisan air mata pada mata kering terkait sindrom Sjögren (SS) yang diberi terapi tetes mata kombinasi sodium hialuronat 0,1% (SH) dan hydroxypropyl (HP)-guar, atau monoterapi tetes mata sodium hialuronat (SH). Sebanyak 17 pasien SS dibagi dalam 2 kelompok. Kelompok pertama mendapat kombinasi SH dan HP-guar, kelompok kedua mendapat terapi SH. NIKBUT, Schirmer, skor pewarnaan okular, dan sitologi impresi, serta keluhan subjektif dinilai sebelum dan sesudah pemberian obat. Setelah terapi selama 28 hari, terdapat peningkatan median NIKBUT, Schirmer, skor pewarnaan okular, densitas sel Goblet, dan perbaikan keluhan subjektif pada mata kering terkait SS.The objectives of the study is to assess the stability of dry eye LAM associated with Sjögren syndrome (SS) during combination therapy of sodium hyaluronate 0.1% (SH) and hydroxypropyl (HP) -guar, or monotherapy sodium hyaluronic (SH). A total of 17 SS patients in this study were divided into 2 groups. The first group received a combination of SH and HP-guar while the second group received SH therapy. NIKBUT, Schirmer, ocular staining score, and impression cytology, as well as subjective complaints was assessed before and after drug administration. After 28 days of therapy, there was a median increase in NIKBUT, Schirmer, ocular staining scores, Goblet cell density, and subjective complaints on SS-related dry eyes. 
Evaluasi Pemeriksaan Imunoglobulin E Spesifik Menggunakan Immunoblot Assay dengan Baku Emas Skin Prick Test -, Yudhistira; Sukartini, Ninik; Immanuel, Suzanna; Rengganis, Iris
Cermin Dunia Kedokteran Vol 46, No 2 (2019): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (561.604 KB) | DOI: 10.55175/cdk.v46i2.517

Abstract

Pendahuluan. Skin Prick Test (SPT) merupakan baku emas diagnosis alergi, tetapi tidak dapat dilakukan pada kondisi tertentu seperti dermatografisme, hamil, tidak dapat lepas obat antialergi, sehingga pemeriksaan IgE spesifik menjadi pilihan. Di Indonesia belum ada data perbandingan pemeriksaan IgE spesifik dengan SPT. Penelitian ini dilakukan untuk menentukan sensitivitas, spesifisitas, PPV, NPV, LR+ dan LR- pemeriksaan IgE spesifik menggunakan analisis immunoblot. Metode. Penelitian menggunakan desain potong lintang. Subjek penelitian adalah pasien poliklinik alergi imunologi. Pengambilan sampel dengan metode non-probability sampling dengan teknik consecutive sampling. Analisis dilakukan terhadap alergen tungau debu rumah (Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicalis) dan kecoa. Hasil. Seratus subjek yang memenuhi kiteria masukan dan tolakan (76% perempuan, rerata usia 38.9 tahun) ikut serta dalam penelitian ini. Sensitivitas empat alergen bervariasi dengan rentang 32.4%-76.8%, spesifisitas 68.0%-85.7%, PPV 54.5%-94.5%, NPV 46.2%-65.3%, LR+ 1.8-5.0, dan LR- 0.3-0.8.Sensitivitas pemeriksaan IgE spesifik cukup baik pada tiga tungau debu rumah tetapi rendah pada kecoa; spesifisitas dan PPV bervariasi cukup sampai baik; NPV cukup baik. Simpulan dan Saran. Uji diagnostik IgE spesifik tungau debu rumah menunjukkan hasil cukup baik. Pemeriksaan IgE spesifik tidak dapat digunakan untuk skrining alergi kecoa.Background. Skin Prick Test (SPT) is considered as gold standard for diagnosis of allergy, but cannot be performed in some conditions such as dermatographism, pregnancy, and unable to abstain from antiallergy drugs. In these conditions, specific-IgE test is a test of choice. But there is no comparison data on specific IgE test with SPT in Indonesia. This study was to investigate sensitivity, specificity, PPV, NPV, LR+, and LR- of specific-IgE test of immunoblot assay kit. Method. The study was cross-sectional. Subjects were patients from allergy-immunology clinic who fulfilled inclusion and exclusion criteria. Sampling was performed using non-probability sampling method with consecutive technique. Analysis was performed for house dust mite allergen (Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicalis) and cockroach. Result. Hundred subjects (76% was female, average age of 38.9 years) were involved. Sensitivity of four allergens were varied with range 32.4%-76.8%, specificity 68.0%-85.7%, PPV 54.5%-94.5%, NPV 46.2%-65.3%, LR+ 1.8-5.0, and LR- 0.3-0.8. Sensitivities of specific-IgE for three species of house dust mite were moderate, but low for cockroach; specificities and PPVs were moderate to high; NPVs were moderate. Conclusion. Diagnostic test of specific-IgE with house dust mite allergen shows adequate result. Specific IgE test cannot be utilized for screening of cockroach allergy. 
Predictors of Mortality in Hospitalized HIV/AIDS Patients Puspitasari, Estie; Yunihastuti, Evy; Rengganis, Iris; Rumende, Cleopas Martin
Jurnal Penyakit Dalam Indonesia Vol. 3, No. 1
Publisher : UI Scholars Hub

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Abstract

Introduction. Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome (HIV/AIDS) is a big problem that threatening in Indonesia and many countries in the world. The knowledge on the characteristics and prediction of outcome were important for patients management. There are no studies on the predictors of mortality in Indonesia. Methods. We performed a retrospective cohort study among hospitalized patients with HIV/AIDS in Cipto Mangunkusumo Hospital between 2011-2013. Datas on clinical, laboratory measurement, outcome (mortality) and causes of death during hospitalization were gathered from medical records. Bivariate analysis using Chi- Square test were used to evaluate seven prognostic factors (male sex, not came from referral hospital, never received/failed to continue antiretroviral therapy (ART), clinical WHO stage 4, hemoglobin level /dL, eGFR level /min/1.73 m2 and CD4+ count ≤200 cell/µL). Multivariate logistic regression analysis was performed to identify independent predictors of mortality. Results. Among 606 hospitalized HIV/AIDS patients (median age 32 years; 64.2% males), 122 (20.1%) were newly diagnosed with HIV infection during the hospitalization and 251 (41.5%) had previously received ART. Median length of stay was 11 (range 2 to 75) days. There were 425 (70.1%) patients being hospitalized due to opportunistic infection. In-hospital mortality rate was 23.4% with majority (92.3%) due to AIDS related illnesses. The independent predictors of mortality in multivariate analysis were clinical WHO stage 4 (OR=6.440; 95% CI 3.701-11.203), hemoglobin level /dL (OR=1.542; 95% CI 1.015- 2.343) and eGFR level /min/1.73 m2 (OR=3.414; 95% CI 1.821-6.402). Conclusions. In-hospital mortality rate was 23.4%. Clinical WHO stage 4, hemoglobin level /dL and eGFR level / min/1.73 m2 were the independent predictors of in-hospital mortality among hospitalized patients with HIV/AIDS.
Peranan Gejala Klinis dan Pemeriksaan Darah Tepi dalam Diagnosis Dini Influenza pada Pasien dengan Gejala Influenza Like Illness Susilo, Adityo; Suwarto, Suhendro; Rengganis, Iris; Harimurti, Kuntjoro
Jurnal Penyakit Dalam Indonesia Vol. 1, No. 2
Publisher : UI Scholars Hub

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Pendahuluan. Influenza merupakan penyakit infeksi yang disebabkan oleh virus influenza. Pada manusia, influenza sering menimbulkan penyakit pernapasan akut dengan manifestasi klinis berupa influenza like illness. Penegakkan diagnosis influenza seringkali sulit oleh karena manifestasi klinis yang tidak khas. Demam disebut sebagai gejala klinis terpenting dan limfopenia didapatkan sebagai suatu temuan laboratoris yang konsisten. Usaha untuk mengetahui proporsi dan mengelaborasi gejala klinis dan pemeriksaan darah tepi sederhana diperkirakan dapat meningkatkan probabilitas diagnosis influenza. Tujuan. Mengetahui proporsi influenza serta mengevaluasi peranan gejala klinis dan pemeriksaan laboratorium sederhana pada pasien penyakit pernapasan akut dengan influenza like illness sehingga dapat digunakan sebagai faktor prediktif terhadap diagnosis influenza. Metode. Studi potong lintang berbasis diagnostic research pada pasien penyakit pernapasan akut dewasa dengan gejala influenza like illness di Puskesmas Kecamatan Pulo Gadung dan Puskesmas Kelurahan Rawamangun antara Maret hingga Juni 2011. Spesimen analisis virus menggunakan bahan apus nasofaringeal, dengan teknik analisis PCR kualitatif dan imunokromatografi antigen. Hasil. Dari 90 orang subyek penelitian didapatkan 13 orang (14,4%) terbukti terinfeksi virus influenza A melalui teknik PCR. Variabel demam menunjukkan hasil uji kemaknaan yang signifikan terhadap influenza (p 0,003) dengan prevalence ratio 6,28 (95% CI 1,476-26,759). Sensitifitas demam, batuk dan pilek terhadap influenza masing-masing adalah 85% dan negative predictive value demam sebesar 98%. Variabel determinan lainnya tidak menunjukkan hasil yang bermakna terhadap influenza pada uji kemaknaan statistik. Simpulan. Proporsi influenza pada pasien dengan gejala ILI diperoleh cukup tinggi dengan proporsi demam yang terbukti lebih tinggi pada pasien influenza. Sensitivitas demam, batuk dan pilek terhadap influenza tinggi dengan negative predictive value yang memuaskan untuk seluruh variabel determinan
Vaksinasi pada Lansia Rengganis, Iris
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 4
Publisher : UI Scholars Hub

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Approach to Diagnosis and Treatment of Drug Allergy Pandapotan, Roy Akur; Rengganis, Iris
Jurnal Penyakit Dalam Indonesia Vol. 4, No. 1
Publisher : UI Scholars Hub

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Drug allergy is a serious medical problem. Drug allergy can be defined as an adverse drug reaction involving immunological mechanism. However, it is not easy to decide whether an adverse drug reaction is an allergic reaction, and it requires a systematically diagnostic approach. Beside a thorough history taking and physical examination, there are general and specific laboratory examination to investigate drug allergy which can be done in vivo, in vitro, or biopsy. The management of drug allergy include the avoidance of the precipitating event, and specific methods to reduce the drug reaction which include threating through, dosing test, desensitization, and the administration of premedication for certain drugs.
Hubungan Antara Gangguan Depresi dengan Kualitas Hidup, Stresor Psikososial, dan Tingkat Kontrol Asma pada Pasien Asma di RSUPN Dr. Cipto Mangunkusumo Putro, Agung W; Kusumadewi, Irmia; Rengganis, Iris; Agiananda, Feranindhya
Majalah Kedokteran Indonesia Vol 68 No 8 (2018): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.68.8-2018-44

Abstract

Introduction : Poor asthma control level and the presence of comorbid disorders such as depression and psychosocial stress will affect the quality of life and increase the economic burden of asthmatic patients and their family. We investigated the correlation between depressive disorders, quality of life, psychosocial stressors, and level of asthma control in asthmatic patients. Methods : The study was cross-sectional descriptive-analytic in 37 asthmatic patients with depressive disorder and 37 asthmatic patients without depressive disorder in the Allergy and Immunology Clinic RSUPN Dr. Cipto Mangunkusumo using SCID-1, WHOQOL-BREF, Holmes and Rahepsychosocial stressors, and ACT questionnaires. Results : There is a relation between the presence of depressive disorders and lower quality of life scores based on physical health (p less-than 0,001), psychological health (p less than 0,001), social relations (p=0.023), environment (p=0.022), psychosocial stressors (OR 3.85; p=0.005), and the level of asthma control (p=0.001) in asthmatic patients. Conclusion: Asthmatic patients with depressive disorders tend to have lower quality of life score in all domains (physical health, psychological health, social relationships, and environment) and lower level of asthma control scores than asthmatic patients without depressive disorders. Asthmatic patients who have psychosocial stressors have 3.8 times higher risk to have depressive disorders.
Correlation of Dermatophagoides Pteronyssinus with Serum Der-P Spesific Ige and Igg4 Nuraeni, Hanny Siti; Wibowo, Heri; Kwarta, Cytyta Putri; Rengganis, Iris
jitek Vol 13 No 1 (2025): September 2025
Publisher : Poltekkes Kemenkes Jakarta III

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32668/jitek.v13i1.1925

Abstract

Repeated exposure to allergens induces an increase in regulatory T cells that produce interleukin 10 (IL-10) that can lead to B cells switching to immunoglobulin G4 (IgG4). Allergen-specific IgE was used as marker of allergen exposure but was only detected in atopic subjects, not in normal subjects. Therefore, an immunological marker that could be used to scan for exposure is needed. This study was conducted to determine Dermatophagoides pteronyssinus (Der p) density, serum IgE and IgG4-specific Der p levels, and to determine the correlation of Der p density with specific serum levels of IgE and IgG4 Der p in normal and atopic subjects. We calculated the amount and density of Der p in house dust mites (HDM) using the Fain and Hart (1986) method and measured Der p serum levels of IgE and IgG4 using indirect ELISA. We found that the most dominant HDM species was Der p. IgE-specific Der p level in atopic asthma patients were higher than in normal patients (p=0.002), whereas IgG4-specific Der p level in both atopic asthma and normal patients did not exhibit significant differences (p= 0.667). The density of Der p demonstrated a positive correlation with IgG4-specific Der p levels (Spearman r=0.388, p=0.008) compared to IgE-specific Der p.Compared to IgE, the density of Der p demonstrated a correlation with Der p-specific serum IgG4 levels, which means that Der p-specific IgG4 can be used to determine the exposure and accumulation of Der p in the residence of subjects.
Association between Food Specific IgG Antibodies with Clinical Activity of Disease in Patients with Inflammatory Bowel Disease Parhusip, Santi Sumihar Rumondang; Rengganis, Iris; Simadibrata, Marcellus; Abdullah, Murdani; Shatri, Hamzah; Yunihastuti, Evy; Wibowo, Heri
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 24, No 1 (2023): VOLUME 24, NUMBER 1, April, 2023
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/241202341-48

Abstract

Background: Inflammatory bowel disease (IBD) is an autoimmune disease that is influenced by food, an important factor in accelerating its clinical disease activity because of intestinal inflammation trough formation of antigen-antibody complex. Food-specific IgG examination can identify the types of person foods consumes that are maybe responsible for disease activity. It is useful in treating IBD without risking malnourishment as it is tailored to the individual immune profile.Method: This is a cross-sectional study involving 113 patients diagnosed with IBD by colonoscopy. Examination of serum IgG specific for 220 types of foods was performed using ELISA and immuno-array techniques. Disease clinical activity was assessed using the Mayo index and Crohn's disease activity index.Results: The highest proportion of dietary IgG in Crohn's disease was peas (100%), barley (97.9%), eggs (95.9%), milk (81.6%), and corn (75.5%); while in ulcerative colitis it was barley (98.4%), peas (96.8%), egg whites (92.2%), corn (82.8%), and prunes (78.1%). In ulcerative colitis, there was a weak negative correlation between cashew nuts IgG (r = -0.347; p = 0.041) and chickpeas IgG (r = -0.473; p = 0.017) with clinical disease activity; while in Crohn's disease, a weak positive correlation with disease activity was seen in barley (r = 0.261; p = 0.042).Conclusion: There was a weak negative correlation between cashew and chickpea-specific IgG antibodies with clinical activity of ulcerative colitis, and a weak positive correlation between barley-specific IgG antibodies and Crohn's disease clinical activity. 
Co-Authors -, Lisnawati -, Yudhistira Adhiatma, Kresna Adityo Susilo, Adityo Agiananda, Feranindhya Agiananda, Feranindhya Agus Joko Susanto, Agus Joko Alimuddin, Suriani Alimuddin, Suriani Cleopas M Rumende, Cleopas M Cleopas Martin Rumende E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Estie Puspitasari, Estie Evy Yunihastuti Fauzi Ahmad Muda Heri Wibowo Ikhwan Rinaldi Irmia Kusumadewi Joedo Prihartono Kuntjoro Harimurti Kwarta, Cytyta Putri Lukman Edwar Marcellus Simadibrata Murdani Abdullah Naufal, Muhammad Afif Nuraeni, Hanny Siti Parhusip, Santi Sumihar Rumondang Pringgodigdo Nugroho, Pringgodigdo Priya Darsini, Indira Putro, Agung W Putro, Agung W Rambe, Dirga S. Roy Akur Pandapotan, Roy Akur Rudi Putranto Rumende, Cleopas M. Siti Setiati Suhendro Suwarto, Suhendro Sukartini, Ninik Susanto, Agus J. Suzanna Immanuel Tri Juli Edi Tarigan