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Baihaqi, Fahri Ahmad
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Factors Associated with Length of Stay of COVID-19 Patients at Serui Regional General Hospital Papua Province: Cross-Sectional Study Baihaqi, Fahri Ahmad; Rumaropen, Henny
Jurnal Penyakit Dalam Indonesia Vol. 8, No. 4
Publisher : UI Scholars Hub

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Abstract

Introduction. Coronavirus Disease 2019 (COVID-19) is a respiratory infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2 has become a global health problem. The length of stay of the patient is related to the use of hospital resources. COVID-19 patients are at risk of increasing length of stay due to various factors and the increased length of stay can increase the burden of health services. The purpose of this study was to determine the factors that influence the length of stay of COVID-19 patients.Methods. An observational analytic study with a cross-sectional design was conducted at Serui Regional General Hospital, Papua Province. The subjects were COVID-19 patients hospitalized from September 2020 – August 2021 who met the inclusion and exclusion criteria. Subjects were selected by purposive sampling technique. The Independent variables were gender, age, fever, cough, sore throat, shortness of breath, myalgia, malaise, headache, anosmia, vomiting, diarrhea, comorbidities, diabetes, hypertension, asthma, tuberculosis, malaria, hemoglobin, leukocytes, platelets, and neutrophil-lymphocyte ratio (NLR). The dependent variable was the length of stay. Data were obtained from medical records. Bivariate analysis was done with chi-square test, Fisher’s test is used as an alternative if the requirements were not met. Significant variables were analyzed with a multivariate logistic regression test.Results. From 48 subjects of COVID-19 patients hospitalized from September 2020 – August 2021 at Serui Regional General Hospital, Papua Province there were 26 subjects (54.2%) with a length of stay >11 days. The median length of stay was 11 days. Multivariate analysis showed that the factors associated with the length of stay in COVID-19 patients were fever (p=0.003; OR 10.59; 95% CI 2.22-50.49) and NLR (p=0.034; OR 4, 55; 95% CI 1.12-18.49).Conclusion. Fever and NLR are factors associated with the length of stay of COVID-19 patients at the Serui Regional General Hospital, Papua Province.
Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Sepsis and Septic Shock: A Meta-Analysis Study Baihaqi, Fahri Ahmad; Delarosa, Dinda Olinda; Ramadhan, Rezki
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
Publisher : UI Scholars Hub

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Introduction. The lactate/albumin ratio is an inflammatory biomarker that has been widely used and suggested as a predictor of mortality in patients with sepsis and septic shock. However, the results are inconsistent. This meta-analysis aimed to evaluate the prognostic value of lactate/albumin ratio as a predictor of mortality in patients with sepsis and septic shock.Methods. The study protocol was registered with PROSPERO (CRD42021286242). A literature search was performed using PubMed, Ovid EMBASE, Ovid MEDLINE, SCOPUS, and Web of Sciences to find all studies evaluating the association between lactate/albumin ratio and mortality in patients with sepsis and septic shock. Meta-analysis was performed to synthesize the overall Standardized Mean Difference (SMD) of the lactate/albumin ratio and the pooled Odds Ratio (OR) for mortality with 95% confidence intervals (95% CI). Heterogeneity was assessed using I2. Publication bias was assessed quantitatively with Egger’s test. Analysis was performed using Stata version 16.Results. Seven studies (n=10,264 patients) were included in the meta-analysis. The meta-analysis results showed that non-survivor had a higher lactate/albumin ratio than survivor (random-effects model; SMD 1.47; 95% CI 0,91-2,04; p <0.001). Higher lactate/albumin ratio was associated with an increased mortality in sepsis and septic shock patients (fixed-effects model; OR 1.49 (95% CI 1.37-1.62); p <0.001).Conclusions. High lactate/albumin ratio was associated with mortality in sepsis and septic shock patients. Thus, lactate/albumin ratio can be used as a predictor biomarker in predicting mortality for sepsis and septic shock patients.
Effect of Bisphosphonate in Preventing Hungry Bone Syndrome in Patients with Primary Hyperparathyroidism Undergoing Parathyroidectomy Baihaqi, Fahri Ahmad; Magdalena, Bellinda; Maria, Suzy
eJournal Kedokteran Indonesia Vol. 13 No. 1 (2025): Vol 13, No. 1 - April 2025
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23886/ejki.13.801.80

Abstract

Primary hyperparathyroidism is a common endocrine disorder that often requires parathyroid-dectomy as a curative measure. However, post-operatively, patients are susceptible to severe and prolonged hypocalcemia, known as post-parathyroidectomy hypocalcemia syndrome (HBS), which can prolong the length of stay and increase the cost of care. Preoperative use of bisphosphonates has been proposed as a potentialtherapy to reduce the incidence of HBS. This EBCR aims to determine the effectiveness of preoperative bisphosphonate administration in reducing the risk of HBS in patients with primary hyperparathyroidism undergoing parathyroidectomy. A systematic literature review conducted through three electronic databases and critical analysis using FAITH tools from the Central of Evidence-based Medicine, University of Oxford, showed that pre-operative administration of bisphosphonates significantly reduces the occurrence of HBS with an overall NNT (Number Needed to Treat) of three. However, further research is needed to validate bisphosphonates’ effectiveness and safety in this context. Overall, these EBCR suggest that bisphosphonates can be considered as part of a preventive strategy for HBS in patients with primary hyperparathyroidism undergoing parathyroidectomy.
Co-Authors Delarosa, Dinda Olinda Magdalena, Bellinda Maria, Suzy Ramadhan, Rezki Rumaropen, Henny