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All Journal Sumatera Medical Journal International Journal of Cell and Biomedical Science
Restimulia, Lia
Departement Of Doctoral Degree Program, Faculty Of Medicine, Universitas Sumatera Utara, Medan, Indonesia. Departement Of Otorhinolaryngology-Head And Neck Surgery, Faculty Of Medicine, Universitas
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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Serum 25-Hydroxyvitamin D Levels as a Predictive Factor for Allergic Rhinitis Restimulia, Lia; Munir, Delfitri
Sumatera Medical Journal Vol. 4 No. 3 (2021): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v4i3.7626

Abstract

Introduction: Allergy and 25-Hydroxyvitamin D deficiency were mentioned to be correlated. Still, there was limited number of studies in determining serum 25-Hydroxyvitamin D levels as a predictive factor, particularly in allergic rhinitis (AR). This study has never been implemented in Indonesia which the main objective was to explore this topic. Methods: Consecutive sampling was used in recruiting the fifteen subjects. Serum 25-Hydroxyvitamin D levels were quantified using electrochemiluminescence immunoassay (ECLIA) method while the total nasal symptom scores were acquired by enumerate all nasal symptoms. Data of serum vitamin D levels and TNSS were analysed statistically.Results: Based on our previous study, the predictive value was illustrated from linier regresion = 10,230 – 0,281 (vitamin D), with negative moderate correlation (r = -0,613). This result can be comparable for someone with vitamin D level of 5.66 ng/mL that could predicted as 8.64 nasal score. Conclusion: 25-Hydroxyvitamin D could be a predictive factor for allergic rhinitis with negative moderate correlation. Hence, in the future research needs to be implemented.
Downregulation of IL-6 and TNF-α Expression with Mesenchymal Stem Cells Therapy in Allergic Rhinitis Rats Models Restimulia, Lia; Dewi, Dian Andriani Ratna; Nazar, Mohammad Ariq; Irawan, Risky Chandra Satria; Ghaissani, Shabrina Syifa; Haryono, Erlina
International Journal of Cell and Biomedical Science Vol 1 No 1 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i1.13

Abstract

Rhinitis is an inflammatory that characterized by nasal symptoms due to the condition of the nasal mucosa that trigerred by an interaction between environmental allergens and immunoglobulin (Ig)E. It is driven by host factors, infection, pathogens and various inflammatory pathways such as TNF-α that released in allergic responses from both mast cells and macrophages through IgE-dependent mechanisms. Secretome hypoxia mesenchymal stem cells (SH-MSCs) contain anti-inflammatory soluble molecules were able to improve the conditions of endothelial damage, inflammation and oxidative stress by decreasing levels of IL-6, TNF-α, ROS and increasing eNOS. This study will investigate the effect of SH-MSCs at a dose of 300 µL on TNF- and IL-6 expression in rat model ovalbumin-induced rhinitis in vivo. Thirty male Wistar rats were randomly divided into 3 groups: control, treatment and sham group that administrated through intramuscular injection. The results of this study found that SH-MSCs can downregulate the inflammatory cytokines TNF-α and IL-6 in rat model ovalbumin-induced rhinitis in vivo
Co-Authors Delfitri Munir Dewi, Dian Andriani Ratna Ghaissani, Shabrina Syifa Haryono, Erlina Irawan, Risky Chandra Satria Mohammad Ariq Nazar