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All Journal International Journal of Cell and Biomedical Science
Haryono, Erlina
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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Downregulation of IL-6 and TNF-α Expression with Mesenchymal Stem Cells Therapy in Allergic Rhinitis Rats Models Restimulia, Lia; Dewi, Dian Andriani Ratna; Nazar, Mohammad Ariq; Irawan, Risky Chandra Satria; Ghaissani, Shabrina Syifa; Haryono, Erlina
International Journal of Cell and Biomedical Science Vol 1 No 1 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i1.13

Abstract

Rhinitis is an inflammatory that characterized by nasal symptoms due to the condition of the nasal mucosa that trigerred by an interaction between environmental allergens and immunoglobulin (Ig)E. It is driven by host factors, infection, pathogens and various inflammatory pathways such as TNF-α that released in allergic responses from both mast cells and macrophages through IgE-dependent mechanisms. Secretome hypoxia mesenchymal stem cells (SH-MSCs) contain anti-inflammatory soluble molecules were able to improve the conditions of endothelial damage, inflammation and oxidative stress by decreasing levels of IL-6, TNF-α, ROS and increasing eNOS. This study will investigate the effect of SH-MSCs at a dose of 300 µL on TNF- and IL-6 expression in rat model ovalbumin-induced rhinitis in vivo. Thirty male Wistar rats were randomly divided into 3 groups: control, treatment and sham group that administrated through intramuscular injection. The results of this study found that SH-MSCs can downregulate the inflammatory cytokines TNF-α and IL-6 in rat model ovalbumin-induced rhinitis in vivo
The Effect of X-Ray Radiation to IL-10 Levels in Secretome Mesenchymal Stem Cells Cosmeceutical Product Antari, Arini Dewi; Ghaissani, Shabrina Syifa; Prawitasari, Salindri; Haryono, Erlina; Adityani, Resanti
International Journal of Cell and Biomedical Science Vol 2 No 4 (2023)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v2i4.27

Abstract

Background: X-ray radiation has been widely used in the pharmaceutical industry because it regenerates and repairs damaged tissues. Objective: In this study, we evaluate the effect of X-ray radiation on the secretome cosmeutical product. Methods: We conducted interleukin 10 (IL-10) analysis by ELISA in each product sample after exposure to X-ray radiation. Results: The levels of IL-10 in each sample were significantly lower than those in the control samples. Moreover, the level of IL-10 in the product samples was significantly higher than that of the control sample. Conclusion: In conclusion, exposure to radiation during shipping or storage of skin care products can potentially damage the proteins in the products by inducing the production of reactive oxygen species (ROS) and decreasing the treatment effectiveness.
Co-Authors Adityani, Resanti Antari, Arini Dewi Dewi, Dian Andriani Ratna Ghaissani, Shabrina Syifa Irawan, Risky Chandra Satria Nazar, Mohammad Ariq Prawitasari, Salindri Restimulia, Lia