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All Journal Indonesian Journal of Health Science Chemistry Education Review
Abdullah, Asriyani
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Chemistry Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Amoebiasis: Etiologi, patofisiologi, morfologi, diagnosis, dan pengobatan Jannah, Insani Fitrahulil; Abdullah, Asriyani
Indonesian Journal of Health Science Vol 5 No 4 (2025)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v5i4.1578

Abstract

Amoebiasis is an infectious disease caused by Entamoeba histolytica and remains a public health concern, especially in developing countries with poor sanitation. Transmission occurs via the fecal–oral route through contaminated food, water, or hands. The infection may be asymptomatic or progress to severe forms such as dysenteric colitis and amoebic liver abscess. Traditional diagnosis relies on stool microscopy, which has limited sensitivity and specificity. Molecular diagnostics such as PCR and immunological methods like ELISA have improved diagnostic accuracy but are not widely accessible in endemic regions. Treatment varies according to disease severity, involving luminal amebicides for non-invasive infections and tissue amebicides for invasive disease. Long-term prevention requires improved sanitation, public education, and vaccine development. Future research should focus on host–parasite interactions, gut microbiota dynamics, and the identification of biomarkers and novel therapies to enable more effective and sustainable control of amoebiasis in affected populations. Amoebiasis adalah penyakit infeksi yang disebabkan oleh Entamoeba histolytica, dan masih menjadi masalah kesehatan masyarakat di negara berkembang dengan kondisi sanitasi yang buruk. Penularan terjadi melalui jalur fekal-oral, baik secara langsung maupun tidak langsung. Infeksi ini dapat bersifat asimtomatik atau menyebabkan gejala berat seperti kolitis disenterik dan abses hati amebik. Diagnosis tradisional mengandalkan pemeriksaan mikroskopis feses, meskipun teknik ini memiliki keterbatasan dalam sensitivitas dan spesifisitas. Kemajuan dalam diagnostik molekuler seperti PCR dan metode imunologis (ELISA) telah meningkatkan akurasi diagnosis, namun aksesnya masih terbatas. Pengobatan tergantung pada tingkat keparahan infeksi, dengan penggunaan amebisida luminal untuk infeksi non-invasif dan amebisida jaringan untuk infeksi invasif. Pencegahan jangka panjang melibatkan peningkatan sanitasi, edukasi masyarakat, dan pengembangan vaksin. Penelitian masa depan harus difokuskan pada interaksi parasit-inang, peran mikrobiota usus, serta penemuan biomarker dan terapi baru untuk pengendalian amoebiasis yang lebih efektif dan berkelanjutan.
Pengembangan E-Modul Asam Basa Berbasis Problem Based Learning melalui Google Classroom pada Sekolah Menengah Kejuruan (SMK) Abdullah, Asriyani; Danial, Muhammad; Anwar, Muhammad
Chemistry Education Review (CER) Volume 5 Nomor 1 September 2021
Publisher : Program Pasca Sarjana UNM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (338.453 KB) | DOI: 10.26858/cer.v5i1.26362

Abstract

This research is a development research that aims to develop and produce an acid- base e-module based on problem-based learning through google classroom at a vocational high school (SMK) which has valid, practical, and effective criteria. The development model used in the study refers to the 4D development model, which consists of the definition stage, the design stage, the development stage, and the dissemination stage. The acid-base e-module based on problem-based learning developed was validated by two experts. After being validated, the acid-base e-module based on problem-based learning was piloted on students at grade  X TKJ 1 at SMKN 5 Jeneponto of academic year 2020/2021 with 27 students. The results show that the acid-base e-module based on problem-based learning developed had conducted a validation process, measuring the level of practicality and effectiveness. The e-module is stated as valid based on the results of the e- module validation with an average value of 3.27 (valid). The e-module is stated as practical based on: (1) the implementation of the acid-base e-module based on problem-based learning at an average value of 1.9 (fully implemented), (2) the teacher's response with an average score of 97.12 (very practical), and (3) the students’ responses with an average score of 81.34 (very practical). E-module is stated as effective based on the results of the N-gain test of 0.76 (high) and classical completeness of 85.19%. Therefore, the results of the study indicate that the acid-base e-module based on problem-based learning has valid, practical, and effective qualities. An outline summary of the acid-base e-module based on problem-based learning through Google Classroom contains a glossary, basic competencies, competency achievement indicators, instructions for using e- modules, concept maps, learning activities 1, 2, and 3, evaluation and answer keys.
Co-Authors Jannah, Insani Fitrahulil Muhammad Anwar Muhammad Danial