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All Journal Indonesian Journal of Health Science Cendana Medical Journal Jurnal Veteriner Nusantara JURNAL FLOBAMORATA MENGABDI
Jannah, Insani Fitrahulil
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Veterinary

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Epigenetik Pada Sindrom Ovarium Polikistik: Gangguan Proses Folikulogenesis Yang Melibatkan Gen Reseptor Androgen, Reseptor Follicle-Stimulating Hormone Dan Reseptor Luteinizing Hormone Arianto, Steven; Radhina, Afifa; Shari, Amalia; Jannah, Insani Fitrahulil; Sari, Mike Permata
Indonesian Journal of Health Science Vol 4 No 1 (2024)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v4i1.683

Abstract

Sindrom Ovarium Polikistik (SOPK) merupakan salah satu gangguan hormonal yang dialami oleh wanita. Gangguan ini menyebabkan disregulasi proses neuroendokrin dan mengganggu proses pembentukan folikel (folikulogenesis). Etiologi gangguan folikulogenesis pada Sindrom Ovarium Polikistik disebabkan oleh reseptor androgen, reseptor follicle stimulating hormone (FSH), dan reseptor luteinizing hormone (LH). Beberapa pendekatan ilmiah digunakan untuk memahami penyebab gangguan folikulogenesis pada Sindrom Ovarium Polikistik, salah satunya epigenetik. Faktor epigenetik seperti metilasi DNA dan modifikasi histon diduga menjadi salah satu penyebab gangguan pengaturan sinyal luteinizing hormone dan follicle stimulating hormone pada folikulogenesis. Sinyal luteinizing hormone dan follicle-stimulating hormone diatur oleh reseptor luteinizing hormone dan reseptor follicle stimulating hormone yang memiliki ekspresi messenger RNA (mRNA) yang berbeda dibandingkan dengan kondisi normal. Reseptor luteinizing hormone diekspresikan secara berlebihan pada sel teka dan sel granulosa, sedangkan reseptor follicle stimulating hormone mengalami represi ekspresi gen pada sel granulosa. Hiperandrogenisme yang dimediasi reseptor androgen juga diatur secara berbeda pada Sindrom Ovarium Polikistik.
Gambaran evaluasi fungsi ginjal (kadar ureum, kreatinin dan asam urat darah) pasca covid-19 di wilayah gang anwar tahun 2022 Jannah, Insani Fitrahulil; Sari, Mike Permata; Radhina, Afifa
Indonesian Journal of Health Science Vol 4 No 6 (2024)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v4i6.1099

Abstract

Coronavirus Disease 2019 (COVID-19) is an acute respiratory syndrome caused by Coronavirus 2 (SARS-CoV-2), which is associated with several diseases, one of which is kidney disease due to the overactivation of the pro-inflammatory ACE/ANGII/AT1R pathway. This results in the overexpression of the ACE2 pathway, leading to an increased binding site for SARS-CoV-2, where the viral antigen can accumulate in the renal tubules and cause acute kidney injury. This research The aims to examine the evaluation of kidney function by measuring blood urea, creatinine, and uric acid levels after the PPKM process to observe any trends in the decline of kidney function among the respondents. Descriptive qualitative research method with a cross-sectional approach. The research subjects are 30 residents of Anwar Alley aged 40-70 years, using purposive sampling conducted in June-July 2022. The research results showed that the largest number of respondents were female, totaling 26 (86.7%), while male respondents numbered 4 (13.3%). The most common age category was 40-49 years, with 18 respondents. The average urea level is 19.19 mg/dl, creatinine is 1.03 mg/dl, and uric acid level is 6.13 mg/dl. There are 2 individuals with high urea levels, 6 individuals with high creatinine levels, and 14 individuals with high uric acid levels. The SARS-CoV-2 antigen can accumulate in the kidneys, potentially causing acute kidney injury, which is characterized by the presence of hematuria, proteinuria, and increased levels of blood urea and creatinine. Penyakit Coronavirus 2019 (COVID-19) adalah suatu sindrom pernafasan akut yang disebabkan oleh Coronavirus 2 (SARS-CoV-2) yang berasosiasi dengan beberapa penyakit salah satunya adalah penyakit ginjal karena adanya overaktivasi Pro immflamantory ACE/ANGII/AT1R yang mengakibatkan overekspresi jalur ACE2 yang menyebabkan peningkatan bindingsite dari SARS-CoV-2 dimana antigen virus bisa terakumulasi di tubulus ginjal dan menyebabkan cidera ginjal akut. Penelitian ini untuk melihat gambaran evaluasi fungsi ginjal dengan pengukuran nilai ureum, kreatinin dan asam urat darah setelah proses PPKM untuk melihat  adanya kecendurungan penurunan fungsi ginjal responden. Metode Penelitian kualitatif deskriptif dengan pendekatan Cross sectional. Subjek penelitian adalah 30 warga gang Anwar usia 40-70 tahun dengan teknik Purposive sampling ada bulan Juni-Juli 2022. Hasil Penelitian didapatkan jumlah responden terbnyak adalah perempuan sebesar 26(86.7%) dan laki-laki sebanyak 4(13,3%) dengan kategori usia terbanyak adalah usia 40-49 tahun sebanyak 18 responden. Rerata kadar ureum adalah 19,19  mg/dl, kreatinin sebesar 1,03  mg/dl dan kadar asam urat sebesar 6,13 mg/dl. Adapun jumlah kadar ureum responden yang tinggi terdapat 2 orang, kreatinin sebanyak 6 orang dan kadar asam urat yang tinggi  sebanyak 14 orang.  Antigen SARS-Cov-2 akan terakumulasi di ginjal yang bisa menyebakan cidera ginjal akut yang ditandai dengan adanya hematuria, proteinuria serta peningkatan nilai ureum dan kreatinin darah.
Amoebiasis: Etiologi, patofisiologi, morfologi, diagnosis, dan pengobatan Jannah, Insani Fitrahulil; Abdullah, Asriyani
Indonesian Journal of Health Science Vol 5 No 4 (2025)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v5i4.1578

Abstract

Amoebiasis is an infectious disease caused by Entamoeba histolytica and remains a public health concern, especially in developing countries with poor sanitation. Transmission occurs via the fecal–oral route through contaminated food, water, or hands. The infection may be asymptomatic or progress to severe forms such as dysenteric colitis and amoebic liver abscess. Traditional diagnosis relies on stool microscopy, which has limited sensitivity and specificity. Molecular diagnostics such as PCR and immunological methods like ELISA have improved diagnostic accuracy but are not widely accessible in endemic regions. Treatment varies according to disease severity, involving luminal amebicides for non-invasive infections and tissue amebicides for invasive disease. Long-term prevention requires improved sanitation, public education, and vaccine development. Future research should focus on host–parasite interactions, gut microbiota dynamics, and the identification of biomarkers and novel therapies to enable more effective and sustainable control of amoebiasis in affected populations. Amoebiasis adalah penyakit infeksi yang disebabkan oleh Entamoeba histolytica, dan masih menjadi masalah kesehatan masyarakat di negara berkembang dengan kondisi sanitasi yang buruk. Penularan terjadi melalui jalur fekal-oral, baik secara langsung maupun tidak langsung. Infeksi ini dapat bersifat asimtomatik atau menyebabkan gejala berat seperti kolitis disenterik dan abses hati amebik. Diagnosis tradisional mengandalkan pemeriksaan mikroskopis feses, meskipun teknik ini memiliki keterbatasan dalam sensitivitas dan spesifisitas. Kemajuan dalam diagnostik molekuler seperti PCR dan metode imunologis (ELISA) telah meningkatkan akurasi diagnosis, namun aksesnya masih terbatas. Pengobatan tergantung pada tingkat keparahan infeksi, dengan penggunaan amebisida luminal untuk infeksi non-invasif dan amebisida jaringan untuk infeksi invasif. Pencegahan jangka panjang melibatkan peningkatan sanitasi, edukasi masyarakat, dan pengembangan vaksin. Penelitian masa depan harus difokuskan pada interaksi parasit-inang, peran mikrobiota usus, serta penemuan biomarker dan terapi baru untuk pengendalian amoebiasis yang lebih efektif dan berkelanjutan.
Peningkatan Pengetahuan dan Keterampilan Tenaga Kependidikan Melalui Pelatihan Bantuan Hidup Dasar di Program Studi Pendidikan Dokter FKKH Universitas Nusa Cendana Wardani, Nimas Prita Rahajeningtyas Kusuma; Tunggal, Deif; Syahrir, Syahrir; Jannah, Insani Fitrahulil; Riwu, Audrey Gracelia; Kale, Maria Laurenci Fany Permata; Upa, Nurul Fatmawati Pua; Purnasari, Cahyani; Kolobani, Mathias Nathaniel
Jurnal Flobamorata Mengabdi Vol. 3 No. 1 (2025): JURNAL FLOBAMORATA MENGABDI
Publisher : Program Studi Pendidikan Guru Sekolah Dasar, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Muhammadiyah Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51494/jfm.v3i1.2433

Abstract

Abstrak: Henti jantung merupakan kasus kegawatdaruratan medis dimana jantung berhenti berfungsi secara medadak sehingga menimbulkan gangguan hemodinamik tubuh hingga dapat menimbulkan kematian jika tidak ditangani segera. Tindakan bantuan hidup dasar (BHD) merupakan serangkaian tindakan pertolongan pertama yang dapat dilakukan untuk memulihkan fungsi pernapasan dan sirkulasi pada seseorang yang mengalami henti jantung. Pelatihan BHD pada tenaga kependidikan yang merupakan kelompok non-medis di lingkungan program studi Pendidikan dokter FKKH Universitas Nusa Cendana bertujuan untuk meningkatkan kapabilitas pegawai dalam melakukan pertolongan pertama serta meningkatkan kesiapsiagaan pegawai dalam kondisi kegawatdaruratan kejadian henti jantung terutama di lingkungan kerja. Metode yang digunakan adalah pelatihan kepada 20 tenaga kependidikan dengan menggabungkan teori, diskusi interaktif, serta praktik simulasi. Hasil dari pelatihan didapatkan peningkatan pengetahuan diukur dari nilai post-test yang jauh lebih baik dibandingkan nilai pre-test. Selain itu, didapatkan peningkatan keterampilan dan kepercayaan diri dari peserta dalam melakukan tindakan BHD pada kasus henti jantung. Kesimpulannya, kegiatan pelatihan BHD bagi tenaga kependidikan di lingkungan program studi Pendidikan Dokter, FKKH Universitas Nusa Cendana terbukti efektif dalam meningkatkan pengetahuan dan keterampilan peserta pelatihan.
Molecular Docking Analysis of Anti-dengue Activity of Moringa oleifera Leaves Bioactive Compounds Riwu, Audrey Gracelia; Jannah, Insani Fitrahulil; Riwu, Katty Hendriana Priscilia; Kale, Maria Laurenci Fanny Permata; Loe, Fhady Risckhy; Asa, Halena Meldy
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.23665

Abstract

Background: Dengue infection is an endemic disease in various tropical regions, including Indonesia, with increasing incidence and mortality rates, and currently, no specific therapy is available. One of the potential targets for therapeutic development is the dengue virus (DENV) envelope (E) protein, which plays a crucial role in viral replication in the host. Objective: This study aimed to explore the potential of bioactive compounds from Moringa oleifera leaves as inhibitors of the E protein through an in silico approach using molecular docking methods. Methods: A total of 17 bioactive compounds from Moringa oleifera leaf extract, based on previous studies, were obtained from the PubChem database, while the target protein structure was retrieved from the Protein Data Bank (RCSB). The drug-likeness properties of the compounds were evaluated using the SwissADME web tool. Molecular docking analysis was performed using PyRx Autodock, followed by 3D visualisation and ligand–protein interaction analysis using PyMOL and Discovery Studio 2.0. Apigenin, chrysin, kaempferol, and quercetin exhibited more negative binding affinity values than the control compound Celgosivir (-6.2 kcal/mol), with respective values of -7.4, -7.3, -7.4, and -7.3 Results: kcal/mol. These compounds also shared key amino acid residues with the control at the active site of the envelope protein. Moreover, all four compounds fulfilled the five drug-likeness criteria, indicating good oral bioavailability. Conclusion: Moringa oleifera leaves show potential as candidate anti-dengue agents through inhibition of the DENV envelope protein. Keywords: Moringa oleifera, molecular docking, dengue, antiviral, envelope protein
Depression Levels Among Nursing Students: A Descriptive Study Tunggal, Deif; syahrir, Syahrir; Asa, Halena Meldy; Jannah, Insani Fitrahulil; Riwu, Audrey Gracelia
Cendana Medical Journal Vol 12 No 2 (2024): Cendana Medical Journal
Publisher : Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/cmj.v12i2.23698

Abstract

Background : Depression is one of the most common mental health disorders and a serious global concern, particularly among university students. Nursing students are highly vulnerable to depression due to academic pressure, professional expectations, and the challenges of clinical and social environments. Objective : This study aimed to assess the level of depression among nursing students at Nusantara Institute of Health Sciences as a foundation for developing targeted mental health interventions. Methods : This research employed a descriptive quantitative design with 55 participants selected using purposive sampling. The instrument used was the Indonesian-validated version of the Patient Health Questionnaire-9 (PHQ-9). Data were analyzed using SPSS version 20.0. The results showed that the majority of respondents were over 20 years old (52.7%), female (67.3%), lived in boarding houses (67.3%), and were self-motivated to pursue nursing education (76.4%). Based on PHQ-9 scoring, 49.1% of the participants experienced mild depression, 9.1% moderate depression, 3.6% moderately severe depression, and 38.2% had no signs of depression. Conclusion: These findings indicate that although most respondents had intrinsic motivation and independent living conditions, mild depressive symptoms remained prevalent. Therefore, early detection and preventive mental health interventions are essential to support academic success and future professionalism among nursing students. Keywords: Depression, Nursing Students, PHQ-9, Mental Health, Early Detection.
Studi In Silico: Potensi Senyawa Spesifik Kulit Batang Faloak (Sterculia quadrifida R. Br) sebagai Anti-Helmintik Riwu, Audrey Gracelia; Riwu, Katty Hendriana Priscilia; Pua Upa, Nurul Fatmawati; Kale, Maria Laurenci Fanny Permata; Jannah, Insani Fitrahulil; Wuhan, Yustinus Oswin Primajuni
Jurnal Veteriner Nusantara Vol 8 No 2 (2025): Agustus, 2025
Publisher : Program Studi Kedokteran Hewan, Universitas Nusa Cendana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35508/jvn.v8i2.25038

Abstract

Helminthiasis remains a significant global public health issue, particularly in tropical and subtropical regions. The extensive and repeated use of synthetic anthelmintic agents, including albendazole and mebendazole, has contributed to the emergence of drug resistance among various parasitic species. Therefore, the exploration of plant-derived compounds with potential anthelmintic activity is urgently needed. This study investigated the potential of bioactive compounds from the stem bark of Faloak (Sterculia quadrifida R. Br) as inhibitors of the Mitochondrial Rhodoquinol-Fumarate Reductase (MRFR) protein through an in silico approach. Five compounds: epicatechin, d-catechin, catechin-(4α→8)-catechin, spinasterol, and spinasterone were analyzed, with Atpeni as the control. Drug-likeness evaluation was conducted using Lipinski’s Rule of Five, while molecular docking, visualization and molecular interaction analysis was performed using PyRx, PyMOL, and Discovery Studio. Four compounds satisfied Lipinski’s criteria, indicating favorable pharmacokinetic properties. Among them, spinasterol and spinasterone demonstrated the strongest binding affinities to MRFR (–10.1 and –9.2 kcal/mol, respectively), exceeding that of the control ligand (–6.4 kcal/mol). Hydrophobic interactions involving key residues such as Leu146, Ala149, and Val153 contributed to complex stability. These results suggest that Faloak stem bark contains promising bioactive compounds that may serve as natural anti-helmintic candidates, warranting further in vitro and in vivo validation
Histoplasmosis: Etiologi, patofisiologi, morfologi, diagnosis, dan pengobatan Jannah, Insani Fitrahulil; Arianto, Steven
Indonesian Journal of Health Science Vol 4 No 6 (2024)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v4i6.1110

Abstract

Histoplasmosis is a fungal infection caused by Histoplasma capsulatum, commonly found in contaminated soil, particularly in endemic areas. This disease is of concern as it can be potentially fatal for individuals with weakened immune systems. This study aims to summarize and analyze current information regarding the etiology, pathophysiology, diagnosis, and treatment of histoplasmosis. The research method employed is a literature review, collecting and analyzing relevant articles from various reputable sources.The findings indicate that diagnosing histoplasmosis is often challenging with conventional methods, such as microscopy and culture, which have limitations in sensitivity and specificity. In contrast, molecular methods like PCR demonstrate better results in detecting infections, especially in difficult cases. The conclusion of this study emphasizes the importance of a comprehensive understanding of histoplasmosis and the need for developing more accurate diagnostic methods to enhance the detection and management of this disease. Histoplasmosis adalah infeksi jamur yang disebabkan oleh Histoplasma capsulatum, yang sering ditemukan di tanah yang terkontaminasi, terutama di daerah endemik. Penyakit ini menjadi perhatian karena dapat berpotensi fatal pada individu dengan sistem imun yang lemah. Penelitian ini bertujuan untuk merangkum dan menganalisis informasi terkini mengenai etiologi, patofisiologi, diagnosis, dan pengobatan histoplasmosis. Metode yang digunakan dalam penelitian ini adalah tinjauan literatur, dengan mengumpulkan dan menganalisis artikel- artikel relevan dari berbagai sumber terpercaya. Hasil penelitian menunjukkan bahwa diagnosis histoplasmosis sering kali sulit dilakukan dengan metode konvensional, seperti mikroskopis dan kultur, yang memiliki keterbatasan dalam sensitivitas dan spesifisitas. Sebaliknya, metode molekuler seperti PCR menunjukkan hasil yang lebih baik dalam mendeteksi infeksi, terutama pada kasus yang sulit. Kesimpulan dari penelitian ini menekankan pentingnya pemahaman yang mendalam tentang histoplasmosis dan perlunya pengembangan metode diagnostik yang lebih akurat untuk meningkatkan deteksi dan penanganan penyakit ini.
Co-Authors Abdullah, Asriyani Arianto, Steven Asa, Halena Meldy Audrey Gracelia Riwu Kale, Maria Laurenci Fanny Permata Kale, Maria Laurenci Fany Permata Kolobani, Mathias Nathaniel Loe, Fhady Risckhy Pua Upa, Nurul Fatmawati Purnasari, Cahyani Radhina, Afifa Riwu, Katty Hendriana Priscilia SARI, MIKE PERMATA Shari, Amalia Syahrir Syahrir Tunggal, Deif Upa, Nurul Fatmawati Pua Wardani, Nimas Prita Rahajeningtyas Kusuma Wuhan, Yustinus Oswin Primajuni