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All Journal Jurnal Biologi Tropis CERATA
Maulidya, Selvira Anandia Intan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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In Silico Evaluation of Typhonium flagelliforme Fatty Acids for Cdc25B Inhibition and Chemotherapy Synergistic Potential Lisnasari, Baiq Risky; Maulidya, Selvira Anandia Intan
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9319

Abstract

Typhonium flagelliforme exhibits cytotoxic activity against various cancer cell lines, including breast cancer. This study employed an in silico approach to evaluate the potential interaction or synergy between its fatty acid derivatives—2-octenoic acid and 2-hexenoic acid—and standard cytotoxic agents in breast cancer therapy. SwissTargetPrediction was used to identify the putative molecular targets of the compounds. Molecular docking was performed against phosphatase Cdc25B (PDB ID: 1CWR) using CB-Dock2, and pharmacokinetic properties were evaluated using SwissADME. Both 2-octenoic acid and 2-hexenoic acid were predicted to target Cdc25A and Cdc25B, which are key regulators of cell cycle progression. Molecular docking revealed binding affinities of −4.42 and −4.60 kcal/mol, respectively, compared to −5.97 kcal/mol for the native inhibitor NSC 663284. These compounds shared multiple key residues in the binding pocket, although they formed fewer hydrogen bonds. Pharmacokinetic predictions showed high gastrointestinal absorption, blood–brain barrier permeability, and no inhibition of major cytochrome P450 enzymes, suggesting minimal interaction with the metabolic pathways of standard chemotherapeutics. The results suggest that T. flagelliforme metabolites may not interfere with cytotoxic drug metabolism but could provide a synergistic effect by targeting cell cycle regulators.
Literature Review: Exploration of Bioactive Components of Avicennia marina and Its Biological Activities Budastra, Cintya; Ulya, Tuhfatul; Maulidya, Selvira Anandia Intan; Purnomo, Indra; Lisnasari, Baiq Risky Wahyu; Permatasari, Lina
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7987

Abstract

Indonesia, as a maritime nation, possesses numerous mangrove ecosystems that have significant potential for exploring their benefits. One species of mangrove that has attracted attention is Avicennia marina, which contains various bioactive compounds. This article aims to provide a comprehensive review of the bioactive components of the Avicennia marina plant and its biological activities, particularly its therapeutic potential and benefits in the pharmaceutical field. We conducted a literature search to find relevant articles in the PubMed, Scopus, and Google Scholar databases using the keywords: plant identification + Avicennia marina; compound identification + Avicennia marina; biological activity + Avicennia marina. The bioactive content from the leaves, fruits, stems, and roots of Avicennia marina has been shown to exhibit antioxidant, antimicrobial, anticancer, and anti-inflammatory effects. This effect is strongly correlated to the presence of active metabolites of triterpenes, terpene alcohols, diterpenes, tannins, dodecanoic acid, octadecanoic acid, phenolic compound, flavonoid, squalene, and phytol. This indicates that Avicennia marina is a promising natural source for further research in the development of a new drug. Our finding further the notion of Avicennia marina as a potential medicinal plant.
Review Artikel : Analisis Pewarna Rhodamin B dan Auramin O Dalam Sampel Makanan Marasabessy, Keysha Nabilla Putri; Maulidya, Selvira Anandia Intan; Rizkika, Adila; Prasasthi, Winiayu Devhi; Mutthoimah, Ulfatul; Salsabila, Putri Syerin
CERATA Jurnal Ilmu Farmasi Vol 16 No 2 (2025): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v16i2.1439

Abstract

Pewarna sintetis seperti rhodamin B dan auramine O dalam produk pangan diketahui memiliki dampak negatif yang signifikan terhadap kesehatan manusia dan penggunaannya telah dilarang. Penelitian ini bertujuan untuk mengevaluasi berbagai metode analisis, termasuk Kromatografi Cair Kinerja Tinggi (KCKT), Spektrofotometri UV-Vis, KCKT fase balik, High-Performance Liquid Chromatography (HPLC), dan Adsorptif Voltammetri Pelepasan. Berdasarkan hasil review, semua metode tersebut telah memenuhi kriteria validasi yang meliputi akurasi, selektivitas, presisi, linearitas, LOD, dan LOQ, yang didukung oleh uji yang tidak bias. Hasil tersebut menekankan pentingnya penerapan metode analisis yang sesuai untuk mendeteksi kandungan pewarna berbahaya serta memastikan keamanan produk pangan yang beredar di pasaran.
Co-Authors Budastra, Cintya Lisnasari, Baiq Risky Lisnasari, Baiq Risky Wahyu Marasabessy, Keysha Nabilla Putri Mutthoimah, Ulfatul Permatasari, Lina Prasasthi, Winiayu Devhi Purnomo, Indra Rizkika, Adila Salsabila, Putri Syerin Ulya, Tuhfatul