Article Per Year (5 Year)
p-Index From 2021 - 2026
0.61
P-Index
This Author published in this journals
All Journal Jurnal Biologi Tropis Journal of Tropical Pharmacy and Chemistry
Maulidya, Selvira Anandia Intan
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
In Silico Evaluation of Typhonium flagelliforme Fatty Acids for Cdc25B Inhibition and Chemotherapy Synergistic Potential Lisnasari, Baiq Risky; Maulidya, Selvira Anandia Intan
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9319

Abstract

Typhonium flagelliforme exhibits cytotoxic activity against various cancer cell lines, including breast cancer. This study employed an in silico approach to evaluate the potential interaction or synergy between its fatty acid derivatives—2-octenoic acid and 2-hexenoic acid—and standard cytotoxic agents in breast cancer therapy. SwissTargetPrediction was used to identify the putative molecular targets of the compounds. Molecular docking was performed against phosphatase Cdc25B (PDB ID: 1CWR) using CB-Dock2, and pharmacokinetic properties were evaluated using SwissADME. Both 2-octenoic acid and 2-hexenoic acid were predicted to target Cdc25A and Cdc25B, which are key regulators of cell cycle progression. Molecular docking revealed binding affinities of −4.42 and −4.60 kcal/mol, respectively, compared to −5.97 kcal/mol for the native inhibitor NSC 663284. These compounds shared multiple key residues in the binding pocket, although they formed fewer hydrogen bonds. Pharmacokinetic predictions showed high gastrointestinal absorption, blood–brain barrier permeability, and no inhibition of major cytochrome P450 enzymes, suggesting minimal interaction with the metabolic pathways of standard chemotherapeutics. The results suggest that T. flagelliforme metabolites may not interfere with cytotoxic drug metabolism but could provide a synergistic effect by targeting cell cycle regulators.
Literature Review: Exploration of Bioactive Components of Avicennia marina and Its Biological Activities Budastra, Cintya; Ulya, Tuhfatul; Maulidya, Selvira Anandia Intan; Purnomo, Indra; Lisnasari, Baiq Risky Wahyu; Permatasari, Lina
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7987

Abstract

Indonesia, as a maritime nation, possesses numerous mangrove ecosystems that have significant potential for exploring their benefits. One species of mangrove that has attracted attention is Avicennia marina, which contains various bioactive compounds. This article aims to provide a comprehensive review of the bioactive components of the Avicennia marina plant and its biological activities, particularly its therapeutic potential and benefits in the pharmaceutical field. We conducted a literature search to find relevant articles in the PubMed, Scopus, and Google Scholar databases using the keywords: plant identification + Avicennia marina; compound identification + Avicennia marina; biological activity + Avicennia marina. The bioactive content from the leaves, fruits, stems, and roots of Avicennia marina has been shown to exhibit antioxidant, antimicrobial, anticancer, and anti-inflammatory effects. This effect is strongly correlated to the presence of active metabolites of triterpenes, terpene alcohols, diterpenes, tannins, dodecanoic acid, octadecanoic acid, phenolic compound, flavonoid, squalene, and phytol. This indicates that Avicennia marina is a promising natural source for further research in the development of a new drug. Our finding further the notion of Avicennia marina as a potential medicinal plant.
In Silico Assessment of GSK-3? Inhibition Activity by Secondary Metabolites of Centella asiatica in the Development of Alzheimer’s Therapy Azariani, Wiwin; Ananto, Agus Dwi; Maulidya, Selvira Anandia Intan
Journal of Tropical Pharmacy and Chemistry Vol. 9 No. 2 (2025): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v9i2.671

Abstract

Alzheimer’s disease involves excessive activity of glycogen synthase kinase-3? (GSK-3?), leading to tau hyperphosphorylation and neurofibrillary tangle formation. This study evaluated the potential of secondary metabolites from Centella asiatica as GSK-3? inhibitors using in silico molecular docking. The GSK-3? structure (PDB ID: 1Q5K) and ten test compounds were docked using YASARA-structure, with method validation yielding an RMSD of 1.890 Å. Naringin, luteolin, and betulinic acid demonstrated the strongest binding affinities -9.2670, -8.1520, and -7.9730 kcal/mol, surpassing the native ligand. Naringin and luteolin interacted with key ATP-binding residues (Asp133, Tyr134, Val135, Lys85), indicating strong competitive inhibitory potential. These findings suggest that C. asiatica metabolites, particularly naringin and luteolin, are promising natural candidates for GSK-3? inhibitor Alzheimer’s therapy.   Keywords:          Centella asiatica; GSK-3?; Molecular Docking; Alzheimer’s Disease; Secondary Metabolites
Co-Authors Agus Dwi Ananto, Agus Azariani, Wiwin Budastra, Cintya Lisnasari, Baiq Risky Lisnasari, Baiq Risky Wahyu Permatasari, Lina Purnomo, Indra Ulya, Tuhfatul