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Permatasari, Lina
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QUALITATIVE AND QUANTITATIVE ANALYSIS OF MEDICINAL CHEMICALS OF “ JAMU REMATIK DAN PEGAL LINU “ IN MAGELANG REGION Haresmita, Perdana Priya; Wardani, Arief Kusuma; Pradani, Missya Putri Kurnia; Permatasari, Lina
Jurnal Ilmu Kesehatan Vol 11 No 2 (2023): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v11i2.3829

Abstract

Jamu for rheumatism and "pegal linu" are two of the most commonly used traditional medicine products in the community, so it is a type of traditional medicine preparation that is prone to the addition of medicinal chemicals. Any type of medicinal chemical should not be added to herbal preparations. The purpose of this study was to determine is there any medicinal chemicals in traditional medicine samples for "pegal linu" and rheumatism in the Magelang area. The total number of samples used is nine. Thin layer chromatography was used to analyze medicinal chemicals in traditional medicine, and preliminary organoleptic test was performed. The next step is a quantitative analysis using the UV-Visible spectrophotometric method. Prednisone, mefenamic acid, and ibuprofen were used as standards. The stationary phase was silica gel 60 F254, and the mobile phase was ethyl acetate: chloroform (4:1) for the prednisone standard, chloroform:methanol (9:1) for the mefenamic acid standard, and chloroform:ethanol (8:1) for the ibuprofen standard. Thin layer chromatography analysis showed that three of the nine traditional medicine samples tested positive for prednisone, but none contained mefenamic acid or ibuprofen. Herbs A, D, and E contained prednisone in their samples. Prednisone concentrations in the three samples were 0,252%; 0.754%, and 2,005%, respectively.
Review: analysis of optimal conditions of bovine serum albumin (BSA) protein denaturation inhibition method in anti-inflammatory activity testing of various plant leaf extracts Nirmala, Annisa Rizka; Permatasari, Lina; Muliasari, Handa; Deccati, Rizqa Fersiyana
Journal of Agritechnology and Food Processing Vol 3, No 2 (2023)
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jafp.v3i2.20953

Abstract

Inflammation is a manifestation of the immune response to eliminate antigens and a process to respond to tissue damage. There are various drugs to control and suppress inflammation, referred to as anti-inflammatory agents. One method to test anti-inflammatory activity is the inhibition of Bovine Serum Albumin (BSA) protein denaturation. This review article will discuss the stages and optimal conditions in the inhibition of BSA protein denaturation method using various leaf extract samples. Literature was gathered from several journal database websites such as PubMed, ScienceDirect, and Google Scholar with keywords "anti-inflammatory," "inhibition of BSA protein denaturation," and "leaf extract," spanning publication years from 2002 to 2023. The results of anti-inflammatory activity tests can be expressed as either percentage inhibition or IC50 values. Optimal conditions were obtained by preparing a 0.2% BSA solution with Tris Buffer Saline (TBS), maintaining a 9:1 composition ratio between the BSA solution and the sample, and heating at an optimal denaturation temperature of 70 °C. Before conducting tests using this method, it is crucial to ensure that the suspected active compounds with anti-inflammatory activity are not degraded at this heating temperature.
Studi awal uji aktivitas enzim amilase dari tumbuhan secara kualitatif berdasarkan perbedaan suhu dan konsentrasi substrat Muliasari, Handa; Permatasari, Lina
Journal of Agritechnology and Food Processing Vol 2, No 1 (2022)
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/jafp.v2i1.9338

Abstract

Amylase enzyme is a starch hydrolyzing enzyme that has wide applications in the food, beverage and biotechnology industries. One source of the amylase enzyme that is easily obtained is plant seeds and sprouts. This research is a preliminary study to qualitatively test the activity of the crude extract of the amylase enzyme from plants. Amylase enzyme was obtained from green bean sprouts, fresh and dried peanut seeds, and fresh and dried corn seeds. The crude extract of the amylase enzyme was tested for its activity using 1% starch as a substrate with variations in temperature and amount of substrate. The result of starch hydrolysis in the form of reducing sugar was detected using Benedict's reagent. The experimental results showed that the amylase enzyme extracted from green bean sprouts and fresh and dried corn kernels showed activity in breaking down starch at 25oC using 6 mL substrate concentration, while dried peanut seeds showed no activity. The enzyme activity is influenced by temperature and the amount of substrate.
EDUKASI STUNTING DAN PELATIHAN PENGOLAHAN MAKANAN BERBAHAN DASAR IKAN DI DESA MENINTING Permatasari, Lina; Muliasari, Handa; Rachmalia Izzatul Mukhlishah, Neneng; Fersiyana Deccati, Rizqa; Anandia Intan Maulidya, Selvira; Junaida, Alfini; Guban Juniarza, A'yuni; Tasya Kamila, Afifah; Hayyatun Nufus, Fadirah; Patya Putri, Hudaynu; Magfira Nurmalasanti, Nadia; Azariani, Wiwin; M. Rifqi Azami S, Lalu; Tunggal Arya Rezky, Noval; Afriza Faishal, Imam
Jurnal Pepadu Vol 5 No 4 (2024): Jurnal PEPADU
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/pepadu.v5i4.5940

Abstract

Stunting merupakan masalah kurang gizi kronis akibat rendahnya asupan gizi pada 1000 hari pertama kehidupan. Stunting juga didefinisikan dengan kondisi tinggi badan seseorang yang kurang dari normal berdasarkan usia dan jenis kelamin akibat dari malnutrisi kronis yang sudah berlangsung bertahun-tahun. Pola makan merupakan salah satu faktor yang menjadi faktor kejadian stunting. Makanan yang tinggi protein hewani, misalnya ikan, merupakan bahan makanan yang mampu mencegah dan mengobati terjadinya stunting. Desa Meninting merupakan salah satu desa di Daerah Lombok Barat, Nusa Tenggara Barat yang mata pencaharian utamanya yaitu nelayan. Banyak jenis ikan laut yang dihasilkan, namun anak-anak tidak menyukai mengkonsumsi ikan. Oleh karena itu, pengabdian ini bertujuan untuk memberikan edukasi terkait stunting pada Ibu-Ibu di Desa Meninting dan memberikan pelatihan cara pengolahan ikan laut menjadi nugget yang lebih disukai oleh anak. Tahapan pada kegiatan ini meliputi persiapan kegiatan, pelaksanaan sosialisasi berupa edukasi terkait stunting dan pelatihan pengolahan ikan laut (ikan tongkol dan ikan guling-guling) dan evaluasi kegiatan melalui pemberian umpan balik oleh peserta. Berdasarkan hasil pendataan, peserta pengabdian 61% merupakan usia produtif (20-40 tahun) dan 79,5% merupakan Ibu Rumah Tangga. Hasil pengabdian menunjukkan bahwa terjadi peningkatan pengetahuan masyarakat terkait stunting setelah dilakukan edukasi stunting. Sementara itu, pelatihan pembuatan nugget berbahan dasar ikan ini 88% responden menyatakan bahwa acara ini sangat penting. Selain itu, 79% responden meyatakan bahwa pengabdian ini sangat bermanfaat bagi mereka. Hasil pengabdian ini dapat dilanjutkan dengan pelatihan lanjutan terkait pengolahan nugget ikan berskala besar, pengemasan dan pendaftaran produk sehingga selain dapat meningkatkan kesehatan, namun dapat meningkatkan perekonomian masyarakat
Determination of Total Flavonoid Content from Extract and Fractions of Mangrove Leaves (Rhizopora mucronata) Sammanta, Rahula Vijja; Permatasari, Lina; Muliasari, Handa; Rachmalia Izzatul Mukhlishah, Neneng; Fersiyana Deccati, Rizqa
Acta Chimica Asiana Vol. 7 No. 2 (2024)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v7i2.199

Abstract

Indonesia, an archipelagic country, includes Lombok Island, known for its extensive mangrove forests, where Rhizopora mucronata is the dominant species. Rhizopora mucronata, from the Rhizoporaceae family, is known for its antibacterial, antifungal, and antioxidant properties due to its secondary metabolites, including flavonoids. However, research on the flavonoid content of its leaves remains unexplored. This study aimed to determine the total flavonoid content in extracts and fractions of R. mucronata leaves using the UV-Vis spectrophotometric method. Leaves were extracted with 96% ethanol using sonication and fractionated with n-hexane, ethyl acetate, and water. The extract and fractions yielded 42.33%, 43.15%, 40.49%, 9.74%, and 32.49%, respectively. TLC tests indicated the presence of flavonoids marked by blue spots. The flavonoid contents in the extract and fractions were 12,980; 14,160; 23,880; and 25,350 mg Quercetin equivalent/gram sample (mg QE/g). The total flavonoid content was analyzed using One-way ANOVA, showing higher levels in the n-hexane and ethyl acetate fractions than in the ethanol extract and water fraction. The high flavonoid content contributes to the biological activities of R. mucronata leaves.
Exploration of secondary metabolite profile in the n-hexane fraction of Rhizophora mucronata, Avicennia marina, and Sonneratia alba Maziya, Raehanul; Permatasari, Lina; Deccati, Rizqa Fersiyana; Muliasari, Handa; Rahman, Fania; Annas, Zulfiana Fatianingrum; Sammanta, Rahula Vijja
Acta Chimica Asiana Vol. 8 No. 1 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i1.231

Abstract

Indonesia is a maritime and archipelagic country with an ocean area of almost two-thirds of its total area, with a coastline stretching 99.123 km from Sabang to Merauke. According to Indonesian Law Number 1 of 2014, it is mentioned that one of the most important biological resources of the coast is mangroves. Some mangrove species commonly found on Lombok Island are Rhizophora mucronata, Sonneratia alba, and Avicennia marina. However, there has not been much exploration of the compound content in these mangroves. Therefore, this study aimed to identify the secondary metabolites of the n-hexane fraction of the three mangrove species using Gas Chromatography-Mass Spectrometry (GC-MS). The leaves of each mangrove species were extracted by sonication method using 96% ethanol solvent, followed by multistage fractionation using n-hexane and water. GC-MS analyzed the n-hexane fraction of each mangrove species. The GC-MS analysis revealed that in the n-hexane fraction of mangrove leaves Rhizophora mucronata and Avicennia marina there were 10 compounds, while Sonneratia alba obtained five compounds. The compounds with the highest intensity in the n-hexane fraction of mangrove leaves of Rhizophora mucronata, Sonneratia alba, and Avicennia marina were squalene (41.71%), ethyl oleate (87.53%), and ethyl oleate (44.02%), respectively. Squalene was reported to have antioxidant and anticancer activities. The ethyl oleate was reported to have bactericidal activity on gram-positive and negative bacteria. The three types of mangrove leaves can be an alternative source of medicine
PEMBUATAN COOKIES DAUN MANGROVE (Rhizophora mucronata) DALAM UPAYA OPTIMALISASI PEMANFAATAN TANAMAN MANGROVE Attaya, Kalisa; Maziya, Raehanul; Amalia, Marshanda Fitri; Bulkis, Nanda; Sutanti, Baiq Novia Rahmadita; Permatasari, Lina
Jurnal Pepadu Vol 6 No 1 (2025): Jurnal Pepadu
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/pepadu.v6i1.6150

Abstract

An unhealthy lifestyle can lead to increased production of free radicals as a byproduct of metabolism. This condition can be mitigated by antioxidants. Rhizophora mucronata offers various health benefits, including its role as an antioxidant. However, public utilization of Rhizophora mucronata remains limited. To enhance its appeal, Rhizophora mucronata was processed into mangrove leaf cookies, making it more convenient for consumption. The objective of this activity was to optimize the utilization of mangrove plants. The activity was conducted on December 20, 2024, at the Meninting Village Hall, Batulayar Subdistrict, West Lombok Regency, with 20 participants. The implementation method included training sessions comprising the delivery of materials on mangrove plants and the process of making mangrove cookies, followed by hands-on cookie-making training. The participants were highly enthusiastic throughout the program, and the material was well understood, as evidenced by the quiz results provided during the session.
Review artikel: validasi metode analisis kadar parasetamol dalam sediaan obat menggunakan berbagai instrumen Zanuba, Anisa; Permatasari, Lina; Febrianingsih, Karlina Dwi; Anindiya, Naya Wahyu; Razkianita, Haulya; Mustika, Mitha Juliana
Sasambo Journal of Pharmacy Vol. 6 No. 1 (2025): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v6i1.502

Abstract

Paracetamol is one of the analgesic-antipyretic drugs that has been widely used by the public as a first-line treatment. The level of paracetamol in each preparation must comply with the standards set in the Indonesian Pharmacopoeia so that it is necessary to determine the level. This study aims to evaluate the validation of the analysis method for paracetamol levels in various drug preparations using three main instruments: infrared spectrophotometry (FTIR), ultraviolet spectrophotometry (UV-Vis), and high-performance liquid chromatography (HPLC). Validation was carried out based on the parameters of accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ). The results showed that the three instruments met the validation requirements set by the Indonesian Pharmacopoeia, with FTIR showing the best precision (RSD 0.03%), UV-Vis having the highest accuracy (% recovery 106.95%), and HPLC having the highest sensitivity with a LOD value of 0.76 µg/mL. For the levels of paracetamol with various dosage forms and instruments, the average results obtained meet the requirements, namely between 90%-110%. Overall, these methods are effective for the analysis of paracetamol levels, providing accurate and consistent results according to pharmacopoeial standards. Based on the review results, the instrument that mostly meets all the requirements for validation of the analysis method is HPLC.
Literature Review: Extraction Methods and Antioxidant Activity of Rhizophora mucronata Leaves Attaya, Kalisa; Saputri, Legis Ocktaviana; Permatasari, Lina
Jurnal Biologi Tropis Vol. 25 No. 2 (2025): April-Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i2.8949

Abstract

Free radicals are highly reactive molecules and can trigger various degenerative diseases, so prevention efforts are needed through effective antioxidants. This study aims to review and analyze the extraction method of R. mucronata leaves in increasing antioxidant activity against DPPH free radicals. This study was conducted through a literature review of experimental research articles obtained from Google Scholar and PubMed databases using specific keywords, covering national and international publications for the period 2015-2025. The obtained articles were analyzed based on the extraction technique, solvent type, and IC₅₀ value reported in the article. The analysis showed that cold extraction methods, especially multi-step maceration with methanol solvent, can produce R. mucronata leaf extracts with very strong antioxidant activity with an IC₅₀ value of 0.04 ppm. The conclusion of this study confirms that extraction technique and solvent selection can affect the antioxidant activity of R. mucronata leaves. These findings support the need for optimization of extraction methods to maximize antioxidant effectiveness in the development of natural antioxidants.
Lipid Profile Animal Trial Model of Metabolic Syndrome with Soggak Coffee Intervention Dewi, Lale Budi Kusuma; Permatasari, Lina; Khusuma, Ari; Agrijanti, Agrijanti
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 1 (2025): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i1.712

Abstract

Sindrom metabolik adalah suatu kondisi yang berhubungan dengan obesitas, diabetes, dislipidemia (hiperkolesterolemia dan hipertrigliseridemia), dan tekanan darah tinggi. Stres oksidatif memiliki keterkaitan dengan sindrom metabolik, makanan kaya flavonoid bermanfaat untuk pencegahan dan perbaikan sindrom metabolik. Songgak adalah kopi yang dicampur dengan rempah-rempah dengan kandungan flavonoid dan fenolik total yang berkorelasi dengan aktivitas antioksidannya. Penelitian ini bertujuan untuk menganalisis efek kopi songgak dalam mencegah sindrom metabolik. Parameter yang diuji adalah profil lipid yang terdiri dari kadar kolesterol total, kadar trigliserida, kadar low-density lipoprotein (LDL), dan kadar high-density lipoprotein (HDL). Sebanyak 24 ekor hewan coba dibagi menjadi 4 kelompok (kelompok kontrol, P1, P2, dan P3).  Semua hewan diberikan makanan tinggi, lipid, dan Propylthiouracil (PTU). Kelompok P1, P2, dan P3 masing-masing diberi 8 gram, 12 gram, dan 16 gram kopi Songgak sedangkan kelompok kontrol tidak diberi kopi Songgak. Setelah perlakuan selama 21 hari, hewan coba diterminasi dan profil lipid diukur. Uji statistik dengan Kruskal Wallis pada kadar total kolesterol dan HDL kolesterol dengan hasil uji nilai P berturut-turut adalah 0,205 dan 0,637 (P>0,05), disimpulkan tidak ada perbedaan antar kelompok perlakuan. Sedangkan kadar trigliserida dan LDL diuji dengan uji parametrik ANOVA, hasil uji nilai sig berturut-turut adalah 0,068 dan  0,748 >0,05 disimpulkan tidak ada perbedaan antar kelompok perlakuan. Walaupun menurut uji ststistik disimpulkan tidak ada perbedaan antar kelompok perlakuan, namun kadar kolesterol total, trigliserida, kolesterol LDL dan kolesterol HDL pada kelompok perlakuan lebih baik daripada kelompok kontrol. Kelompok P2 menunjukkan kadar kolesterol total, gliserida, dan LDL yang terendah dengan kadar secara berurutan yaitu 69,67±11,86; 51,00±892; dan 9,33±3,01 mg/dL. Sementara itu, kadar HDL tertinggi pada kelompok P3. Terdapat penurunan kadar kolesterol total, kolesterol LDL, dan trigliserida, serta peningkatan kadar kolesterol HDL pada kelompok perlakuan. Oleh karena itu, kopi songgak dapat dikembangkan menjadi minuman tradisional untuk mencegah sindrom metabolik.
Co-Authors Abdul Rohman Afriza Faishal, Imam Agrijanti, Agrijanti Aini, Dinatul Alfian G. M, Aji Ali, Baiq Aulia Alya, Ainun Amalia, Marshanda Fitri Anandia Intan Maulidya, Selvira Ananta, Muhammad Naufal Farras Anindiya, Naya Wahyu Annas, Zulfiana Fatianingrum Annas, Zulfiana Fitrianingrum Attaya, Kalisa Azariani, Wiwin Budastra, Cintya Bulkaini (Bulkaini) Bulkis, Nanda Deccati, Rizqa Fersiyana Dewi, Lale Budi Kusuma Djoko Kisworo Enny Yuliani Farhaini, Azizatul Farobbi, Muhammad Iqbal Febrianingsih, Karlina Dwi Fersiyana Deccati, Rizqa Guban Juniarza, A'yuni Hafizah, Gina Tasya Rizka Hafizah, Qori'atul Hajrin, Wahida Hayyatun Nufus, Fadirah Hidayati, Agriana Rosmalina Ichsan Ichsan Ilmi, Hilkatul Istiqamah, Juhratul Junaida, Alfini Kabir, Mila Mayanti Khusuma, Ari Lisnasari, Baiq Risky Wahyu M. Rifqi Azami S, Lalu Maelina, Cici Okta Maesarah, Siti Magfira Nurmalasanti, Nadia Maulidya, Selvira Anandia Intan Maziya, Raehanul Muchlishah, Neneng Rachmalia Izzatul Mukhlishah, Neneng Rachmalia Izzatul Muliasari, Handa Mustika, Mitha Juliana Ni Made Amelia Ratnata Dewi Ningrum, Linda Tuanida Nirmala, Annisa Rizka Nisa Isneni Hanifa Ocktaviana Saputri, Legis Patya Putri, Hudaynu Perdana Priya Haresmita, Perdana Priya Pradani, Missya Putri Kurnia Priya Haresmita, Perdana Purnomo, Indra Putra, Bayu Karunia Putri, Fawwaz Aqila Rachmalia Izzatul Mukhlishah, Neneng Rahman, Fania Rahmayanti, Wulan Desi Razkianita, Haulya Rizka Nirmala, Annisa Rizqullah, Rifqi Rosida, Naela Rosyidi, A. Sammanta, Rahula Vijja Saputra, Yoga Dwi Sasvania, Anisa Sugeng Riyanto Sutanti, Baiq Novia Rahmadita Tasya Kamila, Afifah Tunggal Arya Rezky, Noval Ulya, Tuhfatul Ussarwan, M Ihya Wardani, Arief Kusuma Wardani, Ray Haerul Zaneta, Nabila Destia Zanuba, Anisa