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All Journal Jurnal Kedokteran Brawijaya Jurnal Rekonstruksi dan Estetik
Sintaningrum, Elisabeth Prajanti
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Medicine & Pharmacology

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The Effectiveness of Silicon Wound Dressing for the Healing Process of Contaminated Abrasions Limpat Wihastyoko, Herman Yosef; Siswoyo, Devira; Arviansyah, Arviansyah; Siswanto, Yudi; Agustina, Wilma; Sintaningrum, Elisabeth Prajanti
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.16

Abstract

Wounds are skin disorders caused by pathological processes. Abrasion wounds are a type of acute injury. One of the contributing factors is traffic accidents. More than 1.2 million people died as a result of traffic accidents, while 20-50 million others suffered injuries. Choosing the proper dressing can determine wound healing. This case study aims to determine the effectiveness of silicone wound dressing in the healing process of contaminated abrasion wounds. Contaminated abrasion wounds are contaminated by dirty materials, which potentially cause infection. This case report describes four patients, Mrs. W, Mrs. K, Mr. Y, and Mr. M., who suffered abrasions on the face. Their wounds were cleaned in the operating room under general anesthesia. A silicone wound dressing is applied as the primary dressing. The secondary dressing depends on the amount of the exudate. On the 3rd day after the surgery, the wounds looked dry, so they were cleaned and reapplied with the silicone dressing. On the 7th day, after applying silicone wound dressing, the wound had epithelialized. Silicone wound dressing is a modern type of dressing that is effective for acute wounds as it provides a barrier against external contamination. Our sample shows that wound are abrasion contaminated. The result of silicone wound dressings applied was shown accelerate the wound healing process. Modern dressings accelerate wound healing 20% to 40% faster than conventional dressings, such as gauze, tulle, or gauze.  
PENGARUH ORAL N-ACETYLCYSTEIN TERHADAP POLA FAKTOR PERTUMBUHAN ENDOTEL VASKULAR (VEGF) DAN FAKTOR PERTUMBUHAN FIBROBLAS (FGF) PADA MODEL KERETA LISTRIK TIKUS Sintaningrum, Elisabeth Prajanti; Saputro, Iswinarno Doso; Zarasade, Lobredia
Jurnal Rekonstruksi dan Estetik Vol. 5 No. 1 (2020): Jurnal Rekonstruksi dan Estetik, June 2020
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (781.412 KB) | DOI: 10.20473/jre.v5i1.24315

Abstract

Highlights: Kadar rata-rata VEGF pada kelompok tikus yang menerima NAC lebih tinggi daripada kelompok kontrol. Hasil FGF pada kelompok tikus kontrol lebih tinggi pada hari ke-0 dan hari ke-8 dibandingkan dengan kelompok tikus yang menerima NAC. Di dalam kadar FGF dan VEGF tidak ada perbedaan yang signifikan antara kelompok yang menjalani perlakuan dan kelompok kontrol negatif. Abstrak: Latar Belakang:  Luka bakar listrik  menyebabkan cedera serius dengan mortalitas 20-30% dan 74% korban  selamat  dengan  cedera  permanen  dan  sekuel.  Tingkat  nekrosis  pada luka  bakar  seringkali  sulit  untuk  ditentukan  karena sirkulasi mikrovaskuler pada  jaringan  dalam  terlibat.  N- acetylcysteine  (NAC) dapat mengatasi stres oksidatif dan memiliki efek perlindungan  terhadap  kerusakan  jaringan  dari radikal  bebas,  secara  hipotetis  dengan  sekresi berbagai faktor pertumbuhan yang  mempercepat   penyembuhan   luka.   Penelitian  ini  bertujuan  untuk mempelajari pengaruh NAC terhadap tingkat faktor pertumbuhan endotermal vaskular (VEGF) dan faktor pertumbuhan fibroblast  (FGF)  dalam  model  luka bakar listrik tikus. Metode: Penelitian ini menggunakan desain randomized post-test only control group. Dalam penelitian ini, terdapat empat puluh dua tikus jantan galur Wistar yang ditempatkan dalam enam kelompok. Setiap tikus menerima arus bolak listrik sebesar 220 volt dengan intensitas 450-500 mA pada satu ekstremitas. Pengambilan sampel arteri femoralis dilakukan setelah pemberian dosis pertama NAC, setelah dosis pada hari ketiga, dan setelah delapan hari dari masing-masing dosis. Seluruh spesimen arteri femoralis dikenai pewarnaan dengan metode imunohistokimia dan diperiksa di bawah mikroskop dengan pembesaran 300 kali untuk mengevaluasi ekspresi VEGF dan FGF. Data dari seluruh sampel dikumpulkan dan kemudian dianalisis secara statistik. Hasil: Kadar rata-rata VEGF kelompok tikus yang menerima NAC lebih tinggi daripada kelompok kontrol dari awal pengamatan sampai hari ke 8. Hasil FGF pada  tikus  kontrol  lebih  tinggi  pada  hari  ke-0  dan  hari  ke-8  dibandingkan dengan kelompok tikus yang menerima NAC. Namun, dalam tes yang berbeda tidak ada perbedaan yang signifikan (p>0,05) yang  ditemukan pada pengukuran VEGF dan FGF pada hari yang sama antara kelompok kontrol dan kelompok perlakuan. Kesimpulan: Tidak ada perbedaan yang signifikan pada VEGF dan FGF antara kelompok kontrol negatif dan kelompok yang menjalani perlakuan.
The Effectiveness of Silicon Wound Dressing for the Healing Process of Contaminated Abrasions Limpat Wihastyoko, Herman Yosef; Siswoyo, Devira; Arviansyah, Arviansyah; Siswanto, Yudi; Agustina, Wilma; Sintaningrum, Elisabeth Prajanti
Jurnal Kedokteran Brawijaya Vol. 33 No. 2 (2024)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2024.033.02.16

Abstract

Wounds are skin disorders caused by pathological processes. Abrasion wounds are a type of acute injury. One of the contributing factors is traffic accidents. More than 1.2 million people died as a result of traffic accidents, while 20-50 million others suffered injuries. Choosing the proper dressing can determine wound healing. This case study aims to determine the effectiveness of silicone wound dressing in the healing process of contaminated abrasion wounds. Contaminated abrasion wounds are contaminated by dirty materials, which potentially cause infection. This case report describes four patients, Mrs. W, Mrs. K, Mr. Y, and Mr. M., who suffered abrasions on the face. Their wounds were cleaned in the operating room under general anesthesia. A silicone wound dressing is applied as the primary dressing. The secondary dressing depends on the amount of the exudate. On the 3rd day after the surgery, the wounds looked dry, so they were cleaned and reapplied with the silicone dressing. On the 7th day, after applying silicone wound dressing, the wound had epithelialized. Silicone wound dressing is a modern type of dressing that is effective for acute wounds as it provides a barrier against external contamination. Our sample shows that wound are abrasion contaminated. The result of silicone wound dressings applied was shown accelerate the wound healing process. Modern dressings accelerate wound healing 20% to 40% faster than conventional dressings, such as gauze, tulle, or gauze.  
Co-Authors Agustina, Wilma Arviansyah, Arviansyah Iswinarno Doso Saputro Limpat Wihastyoko, Herman Yosef Siswoyo, Devira Yudi Siswanto Zarasade, Lobredia