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All Journal Jurnal Pengabdian kepada Masyarakat Nusantara Journal of Pharmaceutical (JOP) Jurnal Pharmacia Mandala Waluya
Putra Pratama, Nofran
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Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Uji Aktivitas Antibakteri Fraksi N-Heksana Daun Pepaya (Carica papaya Linn.) Terhadap Escherichia coli dan Staphylococcus aureus Aprillia, Hananing; Putra Pratama, Nofran; Nur'Aini Purnamaningsih
JOURNAL OF PHARMACEUTICAL (JOP) Vol 1 No 2 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Infectious diseases are still a problem for the world of health. Infectious diseases are caused by viral, bacterial and parasitic infections. Inappropriate use of antibiotics in treating bacterial infections can cause antibiotic resistance effects. Prevention of the effects of resistance can be done by looking for natural antibiotic agents derived from plants. One of the potential medicinal plants as antibiotics is papaya leaf. Objective: The objective of study was determine the antibacterial activity of the papaya leaf n-hexane fraction against Escherichia coli and Staphylococcus aureus and to determine the diameter zone of inhibition the papaya leaf n-hexane fraction at 20%; 40%; 60%; 80%; and 100% against Escherichia coli and Staphylococcus aureus. Method: Papaya leaf were extraction by using maceration method of 70% ethanol as solvent. Separation of compounds based on the level of polarity using fractionation method with n-hexane: water (1:1 v/v) solvent then carried out phytochemical screening and separation of compounds using TLC method. The antibacterial activity testing used by agar diffusion method Kirby Bauer with the treatment group of papaya leaf n-hexane fraction with a concentration of 20%; 40%; 60%; 80%; and 100%, the positive control group used Ampicillin 10 μg and the negative control group used Aquades. Result: Diameter zone of inhibition Escherichia coli and Staphylococcus aureus was smallest at 20% was 6,57 ± 0,15 mm and 6,69 ± 0,33 mm, while the diameter zone of inhibition the largest at 100% was 7,92 ± 0,23 mm and 7,94 ± 0,16 mm. Conclusion: The papaya leaf n-hexane fraction concentration of 20%; 40%; 60%; 80%; and 100% had antibacterial activity against Escherichia coli and Staphylococcus aureus. The higher concentration then the larger diameter zone of inhibition formed.
Perbandingan Kadar Total Fenolik dan Flavonoid Ekstrak Etanol Daun, batang, dan Akar Kirinyuh (Chromolaena odorata L.) dengan Menggunakan Metode Spektrofotometri UV-Vis Tommy, Muhammad; Putra Pratama, Nofran; Purnomo Sari, Kurnia Rahayu
Jurnal Pharmacia Mandala Waluya Vol. 1 No. 5 (2022): Jurnal Pharmacia Mandala Waluya
Publisher : Prodi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54883/jpmw.v1i5.48

Abstract

Kirinyuh merupakan gulma yang hidup di daerah tropis maupun subtropis. Tanaman tersebut memiliki kandungan senyawa bioaktif utama seperti alkaloid, saponin, fenolik, tanin, steroid dan flavonoid. Penelitian sebelumnya dilakukan uji eksperimen terkait kandungan senyawa bioaktif pada bagian daunnya saja, sedangkan pada bagian batang dan akar masih sangat sedikit. Tujuan penelitian yaitu mengetahui kadar total fenolik dan flavonoid dalam ekstrak etanol daun, batang, dan akar Kirinyuh serta mengetahui bagian mana yang memiliki kandungan senyawa bioaktif terbesar. Metode penelitian ini dilakukan secara kuantitatif menggunakan metode eksperimental di laboratorium. Masing-masing bagian Kirinyuh dimaserasi menggunakan pelarut etanol 70%. Hasil maserasi yang didapatkan yaitu berupa filtrat, lalu diuapkan sampai menjadi ekstrak kental. Perhitungan jumlah kadar total fenolik dan flavonoid dilakukan dengan mensubstitusikan nilai absorbansi sampel ke dalam hasil regresi kurva baku asam galat dan kuersetin yang diperoleh menggunakan metode spektrofotometri UV-Vis. Hasil nilai kadar total fenolik dihitung %b/b sebagai nilai GAE dan flavonoid dihitung %b/b sebagai nilai QE ekstrak etanol Kirinyuh dengan metode spektrofotometri UV-Vis adalah daun sebesar 44,970 ± 3,725 %b/b dan 38,306 ± 0,195 %b/b, batang sebesar 20,403 ± 4,002 %b/b dan 3,959 ± 1,891%b/b, dan akar 21,381 ± 28,824 %b/b dan 3,289 ± 3,943 %b/b. Nilai kadar total fenolik dan flavonoid terbanyak berada pada bagian daun sebesar 44,970 ± 3,725 %b/b dan 38,306 ± 0,195 %b/b.
Uji Aktivitas Antibakteri Fraksi N-Heksana Daun Pepaya (Carica papaya Linn.) Terhadap Escherichia coli dan Staphylococcus aureus Aprillia, Hananing; Putra Pratama, Nofran; Nur'Aini Purnamaningsih
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 1 No. 2 (2023): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v1i2.1231

Abstract

Background: Infectious diseases are still a problem for the world of health. Infectious diseases are caused by viral, bacterial and parasitic infections. Inappropriate use of antibiotics in treating bacterial infections can cause antibiotic resistance effects. Prevention of the effects of resistance can be done by looking for natural antibiotic agents derived from plants. One of the potential medicinal plants as antibiotics is papaya leaf. Objective: The objective of study was determine the antibacterial activity of the papaya leaf n-hexane fraction against Escherichia coli and Staphylococcus aureus and to determine the diameter zone of inhibition the papaya leaf n-hexane fraction at 20%; 40%; 60%; 80%; and 100% against Escherichia coli and Staphylococcus aureus. Method: Papaya leaf were extraction by using maceration method of 70% ethanol as solvent. Separation of compounds based on the level of polarity using fractionation method with n-hexane: water (1:1 v/v) solvent then carried out phytochemical screening and separation of compounds using TLC method. The antibacterial activity testing used by agar diffusion method Kirby Bauer with the treatment group of papaya leaf n-hexane fraction with a concentration of 20%; 40%; 60%; 80%; and 100%, the positive control group used Ampicillin 10 ?g and the negative control group used Aquades. Result: Diameter zone of inhibition Escherichia coli and Staphylococcus aureus was smallest at 20% was 6,57 ± 0,15 mm and 6,69 ± 0,33 mm, while the diameter zone of inhibition the largest at 100% was 7,92 ± 0,23 mm and 7,94 ± 0,16 mm. Conclusion: The papaya leaf n-hexane fraction concentration of 20%; 40%; 60%; 80%; and 100% had antibacterial activity against Escherichia coli and Staphylococcus aureus. The higher concentration then the larger diameter zone of inhibition formed.
Potensi Antioksidan Ekstrak Metanol Fuli Pala (Myristica fragrans Houtt) Djamaluddin, Rosmiyati R; Putra Pratama, Nofran; Nurhasanah, Devika
JOURNAL OF PHARMACEUTICAL (JOP) Vol. 2 No. 1 (2024): Journal of Pharmaceutical (JOP)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) UNIVERSITAS JENDERAL ACHMAD YANI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jop.v2i1.1517

Abstract

Background : The mace is the part that surrounds the nutmeg seeds. Mace and nutmeg seeds are widely used as a spice in food products and in traditional medicine used as a remedy for stomach pain, analgesics, stimulants. Nutmeg mace also contains flavonoids and phenolics that have potential as antioxidants. Research Objective: Determine the antioxidant activity of methanol extract of nutmeg mace (Myristica fragrans Houtt) in reducing free radicals DPPH Research Method: Nutmeg macaques are extracted using methanol solvents through a maceration process (1:10), then the extracts obtained are tested, namely organoleptic tests, moisture content tests, phytochemical tests, KLT tests, and antioxidant tests using quercetin comparators with varying concentrations, namely 2 ppm, 4 pmm, 6 ppm, 8 ppm, and 10 ppm Research Results: The results of the organoleptis test showed that the methanol extract of nutmeg mace had a deep black color, a distinctive aroma, and a thick texture. 0.83% for moisture content test results. The results of phytochemical screening showed that nutmeg mace methanol extract was positive for flavonoids, phenolics, alkaloids, saponins, and tannins. The KLT test also showed positive results containing flavonoids. The free radical scavenging activity of DPPH from metanol extract of nutmeg mace showed an IC50 value of 13.781 ppm ±SD 0.247 and a standard IC50 value of 4.181 ppm ±SD 0.247 compared to quercetin. Based on statistical analysis, there was no significant difference because the data obtained was 0.074 > 0.05 Conclusion: Methanol extract of nutmeg mace has antioxidant activity in reducing DPPH free radicals and shows an IC50 value of 13.781 ±0,211 ppm which is included in the category of very strong.
Sosialisasi Dan Pengenalan Gerakan Yoga Untuk Mengurangi Kecemasan Pada Ibu Hamil Dan Cara Meminum Fe Secara Tepat Rahayu, Budi; Rahmawati S., Nur; Putra Pratama, Nofran
Jurnal Pengabdian kepada Masyarakat Nusantara Vol. 5 No. 2 (2024): Jurnal Pengabdian kepada Masyarakat Nusantara (JPkMN)
Publisher : Lembaga Dongan Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55338/jpkmn.v5i2.3014

Abstract

Permasalahan utama yang di hadapi ibu hamil terutama ibu hamil primigravida adalah masalah kecemasan terhadap kehamilan dan persalinan serta kehamilan yang sisertai dengan kondisi anemia. Kecemasan akan menimbulkan perasaan tidak nyaman bagi ibu hamil dan juga ibu di masa persalinan. Kecemasan dalam persalinan dapat menimbulkan ketegangan otot-otot polos dan pembuluh darah, sehingga terjadi kekakuan serviks dan hipoksia pada rahim yang menyebabkan impuls nyeri bertambah banyak, impuls nyeri melalui thaloma limbic ke korteks serebri dari akibat menambah rasa takut, sehingga kontraksi Rahim berkurang. Persalinan disertai dengan anemia apabila tidak ditangani secara efektif menyebabkan perdarahan dan infeksi menjadi lebih berat, dan meningkatkan kondisi morbiditas dan mortalitas baik pada ibu dan juga bayinya. Pengabdian masyarakat ini dilaksanakan di tempat praktik mandiri Bidan yang diikuti oleh ibu hamil TM III yang dilaksanakan dalam dua hari yaitu hari pertama pelaksanaan yoga dan hari kedua pemberian edukasi mengenai cara meminum Fe secara tepat, diikuti oleh 10 peserta ibu hamil. Tujuan dari pengabdian kepada masyarakat ini adalah untuk meningkatan pengetahuan ibu hamil TM III tentang pengetahuan cara meminum tablet Fe secara benar dan mengurangi kecemasan dalam proses persalinan melalui yoga. Metode penelitian ini menggunakan Pre experiment dengan rancangan one group pretest dan posttest design dan analisa data menggunakan uji statistic non parametris dengan uji Wilcoxon. Hasil ada peningkatan pengetahuan ibu hamil mengenai konsumsi tablet Fe dan ibu bisa melakukan gerakan dasar yoga terhadap keluhan ketidaknyamanan kehamilan.
Co-Authors Aprillia, Hananing Budi Rahayu, Budi Djamaluddin, Rosmiyati R Nur'Aini Purnamaningsih Nurhasanah, Devika Rahmawati S., Nur Sari, Kurnia Rahayu Purnomo Tommy, Muhammad